Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica

Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica

“…13,14 That is because the angle of repose of drug-loaded silica powder is often more than 40 degrees, indicating poor flowability and leading to difficulty in packing the powder into capsules. Some researchers have put drug-loaded silica directly into capsules regardless of its poor flowability, 15 although Mellaerts et al 16 mixed drug-loaded silica with excipients to improve the flowability for capsule packing. Drug-loaded silica can be pressed into tablets without any pharmaceutical excipients by direct compression, [17][18][19] but the quality of the tablets is not ensured due to the poor compressibility.…”

Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica

“…In combination with XRD results, IMC was proved to be in a non-crystalline state when confined into MCM-41 and SBA-15, which was consistent with previous reports. 49 Nevertheless, in the DSC curves of both 3DOM silica formulations, an endothermic peak at 155°C was corresponding to the meta-stable α-form. In combination with XRD analysis, the coexistence of both amorphous and crystalline IMC in 3DOM silica was proved.…”

Liquisolid systems and aspects influencing their research and development

“…They were originally developed for controlled drug release formulations (67)(68)(69) and their capability to enhance the release of poorly soluble drugs was discovered later (56,70,71). In recent studies, it was observed (72, 73) that drugs lose crystallinity when deposited on the surface of mesoporous silicates, which enhances their dissolution rate.…”