Incremental costs of introducing jet injection technology for delivery of routine childhood vaccinations: Comparative analysis from Brazil, India, and South Africa

Intradermal delivery of vaccines: potential benefits and current challenges

“…32 For India and South Africa, the model indicated that intradermal delivery of reduced doses of hepatitis B vaccine using disposablesyringe jet injectors would increase the overall costs per fully-immunized child by US$ 0.45 and by US$ 0.76, respectively; hepatitis B vaccine is only one of five or six infant vaccines routinely administered in these two countries. In contrast, in Brazil, the model indicated that intradermal reduced doses of hepatitis B and yellow fever vaccines would reduce overall costs per fully-immunized child by US$ 0.11.…”

Impact and Cost-Effectiveness of Haemophilus influenzae Type b Conjugate Vaccination in India

“…However, current government spending on vaccines is very low (around 2% of the national health budget) 63 and US$8.81 per vaccinated child is still far less than other countries with similar economies spend on vaccines. 64,65 In addition, we estimate that about 15% of the additional vaccine program costs would potentially be offset by health care cost savings. Because the Indian health system is dominated by a large private sector, health care costs are largely in the form of out-of-pocket costs, which often result in substantial financial burdens to households.…”

Technologies to Improve Immunization

“…Use of DSJIs likely will entail higher costs because of the higher cost of manufacturing a DSJI syringe and the cost of the durable injector, but modeling indicates the potential for overall cost savings compared with needles and syringes when the indirect costs of iatrogenic disease resulting from the latter are included. 257,275 As with all vaccination systems that require a durable administration device, distributability of the vaccine is restricted by the need to have a device available at every POC when vaccine is delivered. The cost of a jet injector can be negligible if amortized over many doses in high-vaccinationvolume settings.…”

“…68.4C), which was the first DSJI to receive WHO prequalification, in 2013. Various PharmaJet models have been studied for veterinary [186][187][188]268 and human 164,165,255,257,258,[269][270][271] applications. In a bench study testing injection of MMR vaccine through pig * References 154,160,161,[175][176][177][178][179][182][183][184][185][188][189][190][191]198,211,214,217,254,256a,[258][259][260][261][262][263][264][265][266] deeper dermis.…”