Technologies to Improve Immunization

Papania, Mark J.; Zehrung, Darin; Jarrahian, Courtney

doi:10.1016/b978-0-323-35761-6.00068-7

Cited by 21 publications

(29 citation statements)

References 499 publications

(584 reference statements)

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“…Different routes had been applied for vaccine delivery. Generally, vaccination routes include intramuscular injection, skin delivery, intranasal and oral administration [ 58 ]. Intramuscular injection is widely used for immunization because it is easy to apply with a low risk of adverse reactions [ 59 ].…”

Section: Different Route For Vaccine Deliverymentioning

confidence: 99%

Influenza Vaccines toward Universality through Nanoplatforms and Given by Microneedle Patches

Tang

Zhu

Wang

2020

Viruses

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Influenza is one of the top threats to public health. The best strategy to prevent influenza is vaccination. Because of the antigenic changes in the major surface antigens of influenza viruses, current seasonal influenza vaccines need to be updated every year to match the circulating strains and are suboptimal for protection. Furthermore, seasonal vaccines do not protect against potential influenza pandemics. A universal influenza vaccine will eliminate the threat of both influenza epidemics and pandemics. Due to the massive challenge in realizing influenza vaccine universality, a single vaccine strategy cannot meet the need. A comprehensive approach that integrates advances in immunogen designs, vaccine and adjuvant nanoplatforms, and vaccine delivery and controlled release has the potential to achieve an effective universal influenza vaccine. This review will summarize the advances in the research and development of an affordable universal influenza vaccine.

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Section: Different Route For Vaccine Deliverymentioning

confidence: 99%

Influenza Vaccines toward Universality through Nanoplatforms and Given by Microneedle Patches

Tang

Zhu

Wang

2020

Viruses

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“…The exploration of options for human vaccine administration includes the consideration of all possible routes of entry into the body and a wide range of strategies [28]. Currently, using a syringe and needle to inject vaccine through the skin barrier represents the dominant vaccine delivery technology, although the US market includes a limited number of licensed oral (e.g., Rotarix TM , an oral rotavirus vaccine) and intranasal (e.g., FluMist TM ) vaccines [29].…”

Section: Vaccine Delivery Technologiesmentioning

confidence: 99%

Section: Vaccine Delivery Technologiesmentioning

confidence: 99%

“…Historical approaches to develop needle-free delivery technologies for otherwise injectable vaccines led to numerous designs of multiuse nozzle jet injectors, which found widespread use in mass campaigns [28]. However, the US discontinued all use of multiuse nozzle jet injectors due to the potential for bloodborne pathogen transmission risks (from insufficient cleaning between multiple uses) [28]. Subsequent development of disposable-syringe jet injectors led to a functional alternative in the US, but their use can only occur with vaccines for which the vaccine label explicitly allows use of the specific device [28].…”

Section: Vaccine Delivery Technologiesmentioning

confidence: 99%

“…However, the US discontinued all use of multiuse nozzle jet injectors due to the potential for bloodborne pathogen transmission risks (from insufficient cleaning between multiple uses) [28]. Subsequent development of disposable-syringe jet injectors led to a functional alternative in the US, but their use can only occur with vaccines for which the vaccine label explicitly allows use of the specific device [28]. Using disposable-syringe jet injectors thus increases the cost of delivery, both to get the indication included on the label (e.g., Afluria seasonal influenza vaccine [38]) and to pay for the incremental cost of the device and disposable components compared to syringe and needle).…”

Section: Vaccine Delivery Technologiesmentioning

confidence: 99%

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An opportunity to incentivize innovation to increase vaccine safety in the United States by improving vaccine delivery using vaccine patches

Thompson¹,

Orenstein

Hinman

2020

Vaccine

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Innovative vaccine packaging technologies: Perspectives on benefits and challenges of compact prefilled auto‐disable devices and polymer containers

Pagliusi

Jarrett²,

Park

et al. 2023

J Adv Manuf & Process

Self Cite

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Vaccine packaging innovations have a potential impact on the supply chain, as well as acceptability and uptake by users. To better understand recent developments in packaging innovations, we assessed the benefits and challenges of compact pre‐filled auto‐disable devices (CPADs), polymer‐based primary containers (or vials), and dual‐chamber delivery devices. These packaging innovations have clear public health benefits related to ease of use, improved safety, supply logistics, and uptake enabling new vaccination opportunities. In addition, there seems to be high acceptability from users at country‐level. However, uncertain costs including the impact on distribution and cold chain storage have hampered demand and consequently commercialization. For innovations to reach those who can benefit most, global stakeholders should place greater attention on new packaging technologies and assess the trade‐offs between safety, coverage, uptake, ease of administration, wastage and costs.

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Technologies to Improve Immunization

Cited by 21 publications

References 499 publications

Influenza Vaccines toward Universality through Nanoplatforms and Given by Microneedle Patches

Influenza Vaccines toward Universality through Nanoplatforms and Given by Microneedle Patches

An opportunity to incentivize innovation to increase vaccine safety in the United States by improving vaccine delivery using vaccine patches

Innovative vaccine packaging technologies: Perspectives on benefits and challenges of compact prefilled auto‐disable devices and polymer containers

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