Incremental value of MRI for preoperative penile cancer staging

Lucchesi, Fabiano Rubião; Reis, Rodolfo Borges dos; Faria, Eliney Ferreira; Machado, Roberto Días; Rossini, Rodrigo Ribeiro; Borregales, Leonardo D.; Silva, Gyl Eanes Barros; Muglia, Valdair Francisco

doi:10.1002/jmri.25339

Cited by 18 publications

(15 citation statements)

References 30 publications

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“…Few reports have assessed the diagnostic potential of MRI in preoperative evaluation of penile carcinomas; however, inconsistencies in MRI protocols can influence the outcomes and make comparisons difficult [13] . In our study, good agreement was observed between MRI and histopathology for T staging and was similar to or higher than that reported previously [2] , [10] , [11] , [24] , [25] , [26] , including studies wherein MRI was performed after pharmacological erection [2] , [10] , [11] , [26] . We observed a weaker, but still good agreement between MRI and histopathology for N staging.…”

Section: Discussionsupporting

confidence: 90%

Multi-parametric MRI without artificial erection for preoperative assessment of primary penile carcinoma: A pilot study on the correlation between imaging and histopathological findings

Switlyk

Hopland

Sivanesan

et al. 2023

European Journal of Radiology Open

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Section: Discussionsupporting

confidence: 90%

Multi-parametric MRI without artificial erection for preoperative assessment of primary penile carcinoma: A pilot study on the correlation between imaging and histopathological findings

Switlyk

Hopland

Sivanesan

et al. 2023

European Journal of Radiology Open

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“…This could lead to biased interpretation of T1-and T2-weighted sequences, which are the most useful in determining local extent of penile cancer. Moreover, only three studies relied on more than one reader to interpret images [12,14,15]. Nonetheless, these studies reported a kappa inter-observer agreement ranging from moderate to good [25].…”

Section: Discussionmentioning

confidence: 99%

“…The SROC curve depicted diagnostic accuracy of 89% (Figure 2). Four studies [12][13][14][15] evaluated the accuracy of MRI in detecting invasion of TA. Here, pooled sensitivity and specificity were 0.78 (95% CI: 0.69-0.86) and 0.91 (95% CI: 0.86-0.94), respectively.…”

Section: Diagnostic Accuracy Of Mri In Detecting Invasion Of Tunica A...mentioning

confidence: 99%

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Diagnostic Performance of Magnetic Resonance Imaging for Preoperative Local Staging of Penile Cancer: A Systematic Review and Meta-Analysis

et al. 2021

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Invasion of the tunica albuginea (TA) and/or urethra are key factors in determining the feasibility of organ-preserving surgery in penile cancer (PC). Magnetic resonance imaging (MRI) appeared to be a promising technique for preoperative local staging. We performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of MRI in preoperative local staging of primary PC. An SR up to May 2021 was performed according to the PRISMA statement. The diagnostic performance of MRI was evaluated according to TA invasion, urethra invasion, and pT-stage ≥ 2. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled and summary receiver operating characteristic (SROC) curves were constructed. Overall, seven qualified studies were deemed suitable. Diagnostic performance of MRI showed an accuracy of 0.89 for TA invasion (sensitivity 0.78, PPV 0.79, specificity 0.91, and NPV 0.90); an accuracy of 0.88 for urethra invasion (sensitivity 0.65, PPV 0.46, specificity 0.86, and NPV 0.93); an accuracy of 0.90 for pT ≥ 2 (sensitivity 0.86, PPV 0.84, specificity 0.70, and NPV 0.73).Currently available evidence indicates that MRI might be a one-stop shop for local staging of primary PC and play a central role with regard to conservative surgical management.

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“…MRI is another cross-sectional imaging technique to stage ILNs. Lucchesi et al found 13 of 15 (86.7%) cases of ILN involvement using MRI compared to physical exam which identified just 7 of the 15 (46.7%) nodes ( 23 ). MRI may not provide significant additional information over CT scans for ILN imaging but MRI may provide additional information when staging the primary tumor ( Figure 2 ) ( 24 ).…”

Section: Conventional Imagingmentioning

confidence: 99%

Detection of lymph node metastases in penile cancer

Bloom

Mp²,

Patel³

et al. 2018

Transl. Androl. Urol

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Penile cancer (PC) is a relatively rare malignancy in the United States (US) but a greater concern in developing nations. Lymph node imaging remains critical to the staging and treatment of this disease as metastases develop in a predictable, anatomic fashion. Early surgical intervention remains a mainstay in treatment and imaging often aids in decision making. This review highlights the indications for imaging in both low-stage and advanced disease. Furthermore, we discuss the benefits and limitations of currently available imaging for staging of inguinal and pelvic lymph nodes in PC and novel modalities in development.

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Incremental value of MRI for preoperative penile cancer staging

Abstract: 1 J. Magn. Reson. Imaging 2017;45:118-124.

Cited by 18 publications

References 30 publications

Multi-parametric MRI without artificial erection for preoperative assessment of primary penile carcinoma: A pilot study on the correlation between imaging and histopathological findings

Multi-parametric MRI without artificial erection for preoperative assessment of primary penile carcinoma: A pilot study on the correlation between imaging and histopathological findings

Diagnostic Performance of Magnetic Resonance Imaging for Preoperative Local Staging of Penile Cancer: A Systematic Review and Meta-Analysis

Detection of lymph node metastases in penile cancer

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