1988
DOI: 10.1007/bf00176849
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Independence of amphetamine reward from locomotor stimulation demonstrated by conditioned place preference

Abstract: The conditioned place preference (CPP) paradigm is used widely as a measure of a drug's rewarding properties. The present study examined whether the CPP produced by amphetamine is dependent on the locomotor stimulation that is produced by the drug. An earlier study (Swerdlow and Koob 1984) found that interfering with locomotor stimulation using restraint during the drug treatment blocked CPP. The present study examined whether this effect of restraint was indeed due to restriction of locomotion or was due to r… Show more

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Cited by 104 publications
(50 citation statements)
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“…For example, our dernonstration of an initial lack of preference for any chamber during the pre-exposure phase turned into an active avoidance of the chamber previously paired with shock and a preference for the context that was previously associated with safety. This pattern of behaviour s trongly sugges ts that these contexts on1 y acquired biological significance for the animals following conditioning and illustrates that this paradigm is an unbiased procedure (Carr, et al, 1989).…”
Section: Pref Erence Testmentioning
confidence: 64%
“…For example, our dernonstration of an initial lack of preference for any chamber during the pre-exposure phase turned into an active avoidance of the chamber previously paired with shock and a preference for the context that was previously associated with safety. This pattern of behaviour s trongly sugges ts that these contexts on1 y acquired biological significance for the animals following conditioning and illustrates that this paradigm is an unbiased procedure (Carr, et al, 1989).…”
Section: Pref Erence Testmentioning
confidence: 64%
“…Typically in CPP studies, the preference for only one reinforcing stimulus is assessed, but a few studies have assessed the preference for two known reinforcing stimuli, for example, novelty relative to drugs (Carr et al 1988;Bardo et al 1990;Parker 1992). Parker (1992) used the CPP procedure to compare the preference for four choices -a drug-paired chamber, a salinepaired chamber, a novel chamber, and a chamber with prior exposure.…”
Section: Introductionmentioning
confidence: 99%
“…Drug-cue associations play a major role in the drug-seeking behavior that leads to addiction . Drug-seeking depends on motivational circuits in the frontal cortex (Grant et al, 1996;Maas et al, 1998;Tzschentke, 2000;Volkow et al, 2005;Hyman et al, 2006), and is modeled in animals through repeated pairings of drug and a particular environment (Carr et al, 1988;Everitt et al, 1991;Tzschentke and Schmidt, 1998;Carlezon, 2003). Adolescent rats display heightened responding in such models, requiring lower doses of cocaine than adults to form preferences for cocaineassociated environments (Badanich et al, 2006).…”
Section: Introductionmentioning
confidence: 99%