Independent prognostic value of HIF‑1α expression in radiofrequency ablation of lung cancer

Abstract

Radiofrequency ablation (RFA) is widely used in the treatment of lung cancer. Hypoxia-inducible factor-1α (HIF-1α) is a crucial transcription factor regulating oxygen homeostasis that is involved in tumor cell metastasis. The present study investigated the impact of HIF-1α expression and other factors, such as postoperative blood CD4 + /CD8 + ratio, on the prognosis of patients with lung cancer who had received RFA treatment. A total of 80 patients with lung cancer were recruited between January 2011 and October 2016 at The Shenzhen People's Hospital. Lung cancer was confirmed following pathological or histological examination. All patients underwent RFA treatment. Patients were followed up for 6-66 months. HIF-1α expression in lung cancer tissues was assessed by immunohistochemistry. Multivariate survival analysis was performed using Cox proportional hazards model. The results demonstrated that HIF-1α level was low in 36 patients and overexpressed in 44 patients with lung cancer. Kaplan-Meier (KM) curve analysis demonstrated that the overall survival time of patients with high HIF-1α expression was significantly shorter compared with patients with low HIF-1α expression (P<0.05). Furthermore, the results from the KM model and log-rank test revealed that age, Union for International Cancer Control stage, primary or metastatic cancer, chemotherapy, postoperative blood CD4 + /CD8 + ratio, Eastern Cooperative Oncology Group performance status and HIF-1α expression had significant effects on overall survival of patients with lung cancer. The results from Cox analysis demonstrated that high HIF-1α expression, advanced age, clinical staging and chemotherapy were independent risk factors for the prognosis of lung cancer following RFA treatment, and that high HIF-1α expression was associated with the increased risk (5.91-fold) of mortality. In conclusion, the present study demonstrated that HIF-1α expression was increased in lung cancer tissues and was associated with the prognosis of patients with lung cancer who were treated with RFA. These findings suggest that HIF-1α expression may be considered as a marker for evaluating the prognosis of these patients.

3D-CEUS tracking of injectable chemo-sonodynamic therapy-enabled mop-up of residual renal cell carcinoma after thermal ablation

“…It is shown that the active tumor volume of ILA only group increased sharply after treatment, which were even larger than that of the control group. This phenomenon is due to the transient hypoxia condition after thermal treatment, which unfortunately, may lead to the high expression of hypoxia-inducible factor 1 (HIF-1) and angiogenetic growth factor, resulting in the following rapid growth of residual tumors [ [51] , [52] ]. Although in ILA ​+ ​Cur and ILA ​+ ​Cur ​+ ​US groups, the tumor growth were slightly inhibited by the burst diffusion of Cur and the generation of ROS upon US irradiation at the initial stage, the residuals kept their growth progress after the 3rd day of treatment.…”

Advances and controversies in the management of early stage non-small cell lung cancer

“…At the molecular level, hypoxia-inducible factor-1α has been proposed as an independent prognostic marker in the setting of RFA, as high levels have been linked to an increased risk of mortality[ 69 ].…”

The Effect of GLUT1 and HIF-1α Expressions on Glucose Uptake and Patient Survival in Non-Small-Cell Lung Carcinoma

“…Some studies have suggested that HIF-1α may be prognostic in lung cancer, as it could be associated with tumor aggression and related to chemo-resistance [ 37 , 38 , 39 ]. Studies showed that patients with lung cancer and high HIF-1α expression have a significantly shorter overall survival (OS) and that high HIF-1α expression is also associated with tumor metastasis and a higher Eastern Cooperative Oncology Group (ECOG) rating [ 40 ].…”