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Highlights:An adaptive IVA algorithm was proposed for multi-subject complex-valued fMRI data.An MGGD-based nonlinear function was exploited to match varying SCV distributions.The MGGD shape parameter was estimated using maximum likelihood estimation.Subspace de-noising, post-IVA phase de-noising, and noncircularity were utilized.Our method detected more contiguous activations than magnitude-only methods.
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Abstract BackgroundComplex-valued fMRI data can provide additional insights beyond magnitude-only data. However, independent vector analysis (IVA), which has exhibited great potential for group analysis of magnitudeonly fMRI data, has rarely been applied to complex-valued fMRI data. The main challenges in this application include the extremely noisy nature and large variability of the source component vector (SCV) distribution.
New MethodTo address these challenges, we propose an adaptive fixed-point IVA algorithm for analyzing multiplesubject complex-valued fMRI data. We exploited a multivariate generalized Gaussian distribution (MGGD)-based nonlinear function to match varying SCV distributions in which the MGGD shape parameter was estimated using maximum likelihood estimation. To achieve our de-noising goal, we updated the MGGD-based nonlinearity in the dominant SCV subspace, and employed a post-IVA denoising strategy based on phase information in the IVA estimates. We also incorporated the pseudocovariance matrix of fMRI data into the algorithm to emphasize the noncircularity of complex-valued fMRI sources.
ResultsResults from simulated and experimental fMRI data demonstrated the efficacy of our method.
Comparison with Existing Method(s)Our approach exhibited significant improvements over typical complex-valued IVA algorithms, especially during higher noise levels and larger spatial and temporal changes. As expected, the proposed complex-valued IVA algorithm detected more contiguous and reasonable activations than the magnitudeonly method for task-related (393%) and default mode (301%) spatial maps.
ConclusionsThe proposed approach is suitable for decomposing multi-subject complex-valued fMRI data, and has great potential for capturing additional subject variability.