Indeterminate quantiferon TB Gold in Tube results from Turkey

Gürol, Yeşim; Çelik, Gülden Küçükakça

doi:10.5578/tt.9884

Tuberk Toraks

2016

DOI: 10.5578/tt.9884

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Indeterminate quantiferon TB Gold in Tube results from Turkey

Yeşim Gürol

Gülden Küçükakça Çelik²

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2017

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“…Indeterminate results still represent a thorny problem in QFT interpretation. Reported rates of indeterminate QFT results depend on immunosuppressive use in presented populations, and vary from 4% [10], 5% [7], 10% [11], 21% [12] to 29% [4]. Our 5% rate is coherent, given that our cohort was selected without disease-related inclusion criteria.…”

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confidence: 93%

QuantiFERON test interpretation in patients receiving immunosuppressive agents: an alert

Béllière

Blancher

2017

Eur Respir J

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Latent tuberculosis infection (LTBI) diagnosis in immune-mediated inflammatory diseases is complex because of the patient characteristics and the imperfection of available tests [1]. Functional T-cell assays are exposed to bias at several levels (manufacturing, pre-analytical, analytical and immunological) [2] and, unfortunately, the lack of a gold standard precludes higher diagnostic accuracy. However, the QuantiFERON GOLD In-tube test (QFT; QIAGEN, Hilden, Germany) represents a largely used and modern alternative to the tuberculin skin test. Even if performance specifications of QFT are of great interest (specificity of 99% and sensitivity of 84%) [3], some patients remain with an "indeterminate result" because of failed positive control corresponding to the incapacity of lymphocytes to secrete interferon (IFN)-γ after 24 h of stimulation by phytohemagglutinin A (PHA).

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mentioning

confidence: 93%

QuantiFERON test interpretation in patients receiving immunosuppressive agents: an alert

Béllière

Blancher

2017

Eur Respir J

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Indeterminate quantiferon TB Gold in Tube results from Turkey

Cited by 1 publication

References 2 publications

QuantiFERON test interpretation in patients receiving immunosuppressive agents: an alert

QuantiFERON test interpretation in patients receiving immunosuppressive agents: an alert

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