Index of epithelization rate of thermal burns in laboratory animals when application of the “acerbin” preparation

Abstract

Thermal burns in animals represent an urgent problem for veterinary medicine, since the anti-burn drugs available on the world pharmacological market are not always adapted for use on animals and are approved for use in veterinary medicine. In this regard, the aim of the work was to use the wound healing spray “Acerbin” for medical purposes in the treatment of thermal burns and to evaluate its therapeutic efficacy by the rate of epithelialization of burn defects in the skin in laboratory animals. The work was carried out at the Department of Surgery and Therapy of the Kursk State Agricultural Academy, on laboratory white mice in the amount of 60 individuals, in which thermal burns were simulated in the croup and treated with applications of the Acerbin spray. To assess the rate of growth of epithelialization, planimetric measurements of the area of burns were carried out before treatment on the 3rd, 5th, 7th, 10th and 14th days of treatment, as well as the corresponding mathematical calculations of the rate of reduction of burn defects. According to the research results, it was found that when applying the Acerbin spray, the burn rate index on the 3rd day was 0.25 ± 0.06; on the 5th day 0.58 ± 0.03; on the 7th day 0.74 ± 0.01; on the 10th day 0.86 ± 0.02; on the 14th day 0.95 ± 0.01. Thus, at the end of the therapeutic period, the index of the epithelialization rate of thermal burns approached the most physiologically justified numerical expression equal to “1.0”, which allows it to be recommended for use in veterinary medicine as the preparation of choice for the treatment of thermal burns of the skin in animals.