India’s syndemic of tuberculosis and COVID-19

Shrinivasan, Rukmini; Rane, Saurabh; Pai, Madhukar

doi:10.1136/bmjgh-2020-003979

Cited by 58 publications

(46 citation statements)

References 16 publications

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“…There is a dearth of published literature on outcome of SARS-CoV-2 infected children with various comorbidities [8][9][10][11]. Three children with disseminated tuberculosis developed acute respiratory distress syndrome (ARDS) and multi-organ failure syndrome (MODS), and one died due to raised intracranial tension with neurogenic shock.…”

Section: Discussionmentioning

confidence: 99%

Impact of Comorbidities on Outcome in Children With COVID-19 at a Tertiary Care Pediatric Hospital

et al. 2021

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Objective To study the various comorbidities and their impact on outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected children. Methodology Review of medical records of 120 children (58.4% males), aged 1 month to 18 years, admitted between 1 March and 31 December, 2020 with at least one positive RT-PCR test for SARS-CoV-2. Clinical and demographic variables were compared between children with and without co-morbidities. Results 62 (51.7%) children had comorbidities. The most common comorbidity was tuberculosis (32.3%) followed by other infections (27.4%) and hematological (19.4%) conditions. Fever (89.2%) was the most common clinical feature followed by respiratory (52.5%) and gastrointestinal (32.5%) manifestations. There was no significant difference in the severity of COVID illness, length of hospital stay and adverse outcomes (ventilation and mortality) among children with and without comorbidities. Conclusion The presence of a comorbid illness in pediatric inpatients with COVID-19 did not impact the illness severity, length of hospitalization, ventilation requirement and mortality.

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Section: Discussionmentioning

confidence: 99%

Impact of Comorbidities on Outcome in Children With COVID-19 at a Tertiary Care Pediatric Hospital

et al. 2021

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“…TB centres in Brazil, 25 Kenya, 25 the Philippines, 41 Russia, 25 South Africa, 49 Sierra Leone 25 and Zambia 50 reported relative declines in preventive therapy enrolment of 30–70%, although in the Philippines this decline appears to be consistent with pre-pandemic recent trends, and in South Africa as well as one Brazilian centre, preventive therapy enrolment seems to have recovered to pre-COVID levels. Meanwhile, India 31 , 51 and Pakistan 52 , 53 reported major decreases in relative BCG vaccination coverage of up to 60%, with significant potential consequences for paediatric TB mortality in particular. 54 …”

Section: Tb Health Servicesmentioning

confidence: 99%

The impact of COVID-19 on TB: a review of the data

McQuaid¹,

Vassall

Cohen

et al. 2021

int j tuberc lung dis

223

127

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Early in the COVID-19 pandemic, models predicted hundreds of thousands of additional TB deaths as a result of health service disruption. To date, empirical evidence on the effects of COVID-19 on TB outcomes has been limited. Here we summarise the evidence available at a country level, identifying broad mechanisms by which COVID-19 may modify TB burden and mitigation efforts. From the data, it is clear that there have been substantial disruptions to TB health services and an increase in vulnerability to TB. Evidence for changes in Mycobacterium tuberculosis transmission is limited, and it remains unclear how the resources required and available for the TB response have changed. To advocate for additional funding to mitigate the impact of COVID-19 on the global TB burden, and to efficiently allocate resources for the TB response, requires a significant improvement in the TB data available.

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“…: DRC, Nigeria, South Africa). Therefore, among priority, national TB programs should focus on actively finding millions of individuals with TB missed over 2020 (Global Tuberculosis Report 2020, n.d.; Shrinivasan et al, 2020). On the other hand, the WHO estimated that a 6-month disruption in ART delivery could result in up to half a million additional AIDS-related deaths, double the mother-to-child HIV transmission rates in SSA over one year, and increase AIDS-related mortality by up to 40% over the next 5 years (Hogan et al, 2020).…”

Section: Hiv Drugs Repurposed For Treatment And/or Prevention Of Covid-19mentioning

confidence: 99%

Minimizing the impact of the triple burden of COVID-19, tuberculosis and HIV on health services in sub-Saharan Africa

Nachega¹,

Kapata²,

Sam-Agudu³

et al. 2021

International Journal of Infectious Diseases

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India’s syndemic of tuberculosis and COVID-19

Cited by 58 publications

References 16 publications

Impact of Comorbidities on Outcome in Children With COVID-19 at a Tertiary Care Pediatric Hospital

Impact of Comorbidities on Outcome in Children With COVID-19 at a Tertiary Care Pediatric Hospital

The impact of COVID-19 on TB: a review of the data

Minimizing the impact of the triple burden of COVID-19, tuberculosis and HIV on health services in sub-Saharan Africa

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