Indication of cocarcinogenic potential of chronic UMTS-modulated radiofrequency exposure in an ethylnitrosourea mouse model

Tillmann, Thomas; Ernst, Heinrich; Streckert, Joachim; Zhou, Yi; Taugner, Felicitas; Hansen, V.; Dasenbrock, Clemens

doi:10.3109/09553001003734501

Cited by 51 publications

(45 citation statements)

References 40 publications

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“…Effects on tumour susceptibility in mice exposed to a UMTS (universal mobile telecommunications system) test signal from fetal time for up to 24 months were studied by Tillmann et al [45]. Animals were exposed to UMTS fields with intensities of 0, 4.8, and 48 W/m 2 .…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of Mobile Phone and Cordless Phone Use and Glioma Risk Using the Bradford Hill Viewpoints from 1965 on Association or Causation

Carlberg

Hardell

2017

BioMed Research International

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Objective. Bradford Hill's viewpoints from 1965 on association or causation were used on glioma risk and use of mobile or cordless phones. Methods. All nine viewpoints were evaluated based on epidemiology and laboratory studies. Results. Strength: meta-analysis of case-control studies gave odds ratio (OR) = 1.90, 95% confidence interval (CI) = 1.31–2.76 with highest cumulative exposure. Consistency: the risk increased with latency, meta-analysis gave in the 10+ years' latency group OR = 1.62, 95% CI = 1.20–2.19. Specificity: increased risk for glioma was in the temporal lobe. Using meningioma cases as comparison group still increased the risk. Temporality: highest risk was in the 20+ years' latency group, OR = 2.01, 95% CI =1.41–2.88, for wireless phones. Biological gradient: cumulative use of wireless phones increased the risk. Plausibility: animal studies showed an increased incidence of glioma and malignant schwannoma in rats exposed to radiofrequency (RF) radiation. There is increased production of reactive oxygen species (ROS) from RF radiation. Coherence: there is a change in the natural history of glioma and increasing incidence. Experiment: antioxidants reduced ROS production from RF radiation. Analogy: there is an increased risk in subjects exposed to extremely low-frequency electromagnetic fields. Conclusion. RF radiation should be regarded as a human carcinogen causing glioma.

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Section: Resultsmentioning

confidence: 99%

“…The results by Tillmann et al [45] gained further interest based on the results in a follow-up study published in 2015 [46]. The exposure levels were 0 (sham), 0.04, 0.4, and 2 W/kg SAR.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Mobile Phone and Cordless Phone Use and Glioma Risk Using the Bradford Hill Viewpoints from 1965 on Association or Causation

Carlberg

Hardell

2017

BioMed Research International

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“…The group that was ENU-treated and UMTS-exposed at 4.8 W/m 2 exhibited an increased rate of lung tumours and an increased incidence of lung carcinomas as compared with the controls treated with ENU alone. The authors concluded that the study demonstrated a co-carcinogenic effect of lifelong UMTS exposure in female mice subjected to pretreatment with ENU (18). …”

Section: Introductionmentioning

confidence: 96%

“…The effects on tumour susceptibility in mice exposed to a UMTS test signal from the fetal period for up to 24 months was studied by Tillman et al (18). Animals were exposed to UMTS fields with intensities of 0, 4.8 and 48 W/m 2 .…”

Section: Introductionmentioning

confidence: 99%

High radiofrequency radiation at Stockholm Old Town: An exposimeter study including the Royal Castle, Supreme Court, three major squares and the Swedish Parliament

Hardell

Carlberg

Koppel

et al. 2017

Molecular and Clinical Oncology

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Exposure to radiofrequency (RF) radiation was classified as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer at WHO in 2011. The exposure pattern is changing due to the rapid development of technology. Outdoor RF radiation level was measured during five tours in Stockholm Old Town in April, 2016 using the EME Spy 200 exposimeter with 20 predefined frequencies. The results were based on 10,437 samples in total. The mean level of the total RF radiation was 4,293 µW/m2 (0.4293 µW/cm2). The highest mean levels were obtained for global system for mobile communications (GSM) + universal mobile telecommunications system (UMTS) 900 downlink and long-term evolution (LTE) 2600 downlink (1,558 and 1,265 µW/m2, respectively). The town squares displayed highest total mean levels, with the example of Järntorget square with 24,277 µW/m2 (min 257, max 173,302 µW/m2). These results were in large contrast to areas with lowest total exposure, such as the Supreme Court, with a mean level of 404 µW/m2 (min 20.4, max 4,088 µW/m2). In addition, measurements in the streets surrounding the Royal Castle were lower than the total for the Old Town, with a mean of 756 µW/m2 (min 0.3, max 50,967 µW/m2). The BioInitiative 2012 Report defined the scientific benchmark for possible health risks as 30–60 µW/m2. Our results of outdoor RF radiation exposure at Stockholm Old Town are significantly above that level. The mean exposure level at Järntorget square was 405-fold higher than 60 µW/m2. Our results were below the reference level on 10,000,000 µW/m2 established by the International Commission on Non-Ionizing Radiation Protection (ICNIRP), which, however, are less credible, as they do not take non-thermal effects into consideration and are not based on sound scientific evaluation. Our highest measured mean level at Järntorget was 0.24% of the ICNIRP level. A number of studies have found adverse, non-thermal (no measurable temperature increase) health effects far below the ICNIRP guidelines.

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“…As there is evidence that mobile phones cause a thermal, heating effect [30], it could be argued that inner ear temperature fluctuations between the conditions may have confounded the findings. On the other hand, it has also been reported that any changes in cerebral blood flow due to mobile phone radiation, assessed by positron emission tomography, are unlikely to be temperature-related [31,32]. This issue needs further investigation.…”

Section: Discussionmentioning

confidence: 93%

Interference of mobile phones with electrophysiology and emotions

Roggeveen¹

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Document Version:Publisher's PDF, also known as Version of record Please check the document version of this publication:• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:www.umlib.nl/taverne-license Take down policyIf you believe that this document breaches copyright please contact us at:repository@maastrichtuniversity.nl providing details and we will investigate your claim. Background of the mobile phone 'We won!' shouted the Greek soldier Pheidippides in 490 BC after he had run nonstop from the battlefield of Marathon to Athens. According to legend, after delivering the message to the people of Athens, Pheidippides collapsed and died. In those days, quickly sending a message over a large distance was not easy, not without apparent danger to the messenger's health or life! Communication is an essential part of (human) life, and thus, many studies and experiments have been conducted to develop easier ways of sending a message from one place to another. After centuries of mainly direct verbal, nonverbal and written communication, Scottish inventor Alexander Graham Bell patented the telephone in 1876. It was the first device which enabled people to speak to each other across large distances. Appropriately enough, the word telephone originates from the Greek language: τήλε (tèle) means 'far' and φωνή (phónè) means 'sound'. The traditional telephone was (and is) physically connected to the telephone network with the use of wires. Soon, the need for a portable phone arose so that people could talk to others from anywhere. The first mobile phone call with an apparatus which is comparable to what is now known as the mobile phone was made in 1973. Martin Cooper, a Motorola researcher and executive, walked ...

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Indication of cocarcinogenic potential of chronic UMTS-modulated radiofrequency exposure in an ethylnitrosourea mouse model

Abstract: This pilot study indicates a cocarcinogenic effect of lifelong UMTS exposure (4.8 W/m(2)) in female B6C3F1 descendants subjected to pretreatment with ethylnitrosourea.

Cited by 51 publications

References 40 publications

Evaluation of Mobile Phone and Cordless Phone Use and Glioma Risk Using the Bradford Hill Viewpoints from 1965 on Association or Causation

Evaluation of Mobile Phone and Cordless Phone Use and Glioma Risk Using the Bradford Hill Viewpoints from 1965 on Association or Causation

High radiofrequency radiation at Stockholm Old Town: An exposimeter study including the Royal Castle, Supreme Court, three major squares and the Swedish Parliament

Interference of mobile phones with electrophysiology and emotions

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