Indications and Techniques for Biopsy

Obeng‐Gyasi, Samilia; Grimm, Lars J.; Hwang, Eugene; Klimberg, V. Suzanne; Bland, Kirby I.

doi:10.1016/b978-0-323-35955-9.00028-3

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…8,9 In order to accurately localise these lesions, several techniques have been documented, each with its own advantages and drawbacks. 1,7,10 The wire-guided localisation (WGL) technique is the most widely used and preferred method of choice in many centres worldwide. 11,12,13 Despite its widespread use, WGL does have many reported disadvantages such as patient discomfort, technical difficulty and risk of complications.…”

Section: Introductionmentioning

confidence: 99%

Radioguided occult lesion localisation: A retrospective audit at a single tertiary academic breast unit

Ismail

Malherbe

Panieri

et al. 2022

South African Journal of Oncology

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Background:The radioguided occult lesion localisation (ROLL) technique was introduced at Groote Schuur Hospital in 2003 replacing the wire-guided localisation (WGL) technique. In the case of preoperative histologically proven impalpable breast cancers, a sentinel lymph node (SLN) biopsy was done simultaneously (sentinel node [SN] with occult lesion localisation or SNOLL).Aim: To assess the efficacy of the ROLL and SNOLL techniques for diagnostic and therapeutic excisions.Setting: A retrospective record analysis of 190 patients who underwent a ROLL procedure for diagnostic or therapeutic excision of occult breast lesions was performed at a large tertiary hospital in the Western Cape.Methods: Data were collected on patient and tumour characteristics, successful localisation rates, the volume of tissue removed, complete tumour resection rates, the number of re-operations performed and the proportion of SLN detection. The Pearson's chi-squared test was used to test for significance between variables at α = 0.05.Results: Correct radiopharmaceutical placement was achieved in 177/190 (93.2%) lesions. Histologic examination of excised specimens confirmed 115/190 (61.0%) malignant and 75/190 (39.0%) benign lesions. Involved margins were found in 37/115 (32.2%). Complete excision with adequate margins occurred in 50/70 (71.4%) of cases of invasive cancer and in 11/45 (24.4%) of ductal carcinoma in situ (DCIS). The SN was successfully identified in 30/37 (81.1%) of SNOLL cases. Conclusion:Radioguided occult lesion localisation is an effective tool in the preoperative localisation of occult lesions for surgical biopsy as well as the removal of impalpable breast cancers. A single intratumoural injection with 99m Tc nanocolloid combined with lymphoscintigraphy is a reliable method of localising the SN. Contribution:The researchers' observations support that the ROLL and SNOLL techniques assessed in this study are practical and reliable procedures to perform.

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Section: Introductionmentioning

confidence: 99%

Radioguided occult lesion localisation: A retrospective audit at a single tertiary academic breast unit

Ismail

Malherbe

Panieri

et al. 2022

South African Journal of Oncology

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Primary/Neoadjuvant Treatments

Mert

Demir

2021

Breast Cancer Essentials

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Feasibility and Accuracy of Ultrasound-Guided Core Needle Biopsy for Nipple Lesions: A Pilot Study

O’Brien,

Medrano,

Birnbaum

et al. 2024

Journal of Breast Imaging

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Background Due to the superficial location, suspicious findings of the nipple-areolar complex (NAC) are not amenable to stereotactic or MRI-guided sampling and have historically necessitated surgical biopsy or skin-punch biopsy. There are limited reports of US-guided core biopsy of the nipple (US-CBN). Objective We report our nearly 3-year pilot experience with US-CBN at an academic breast imaging center. Methods An institutional review board–exempt and HIPAA-compliant retrospective review was performed. We assessed patient demographics, breast imaging characteristics, procedural data, pathology, and outcomes. Results Nine female patients aged 27 to 64 underwent US-CBN from January 2021 to October 2023. Initial imaging abnormalities included abnormal MRI enhancement, mammographic calcifications, and sonographic masses. After initial or second-look US, all imaging findings had sonographic correlates for biopsy specimens, the majority of which were sonographic masses (8/9). US-CBN was performed by 6 breast radiologists using a variety of devices. All biopsy specimen results were concordant with sonographic abnormalities, although 1 was considered discordant from the initial abnormality seen on MRI. There were no complications, and discomfort during the procedure was well-treated. Two patients (22%, 2/9) were diagnosed with malignancy. Conclusion This pilot study demonstrated that US-CBN can be performed by a breast radiologist for definitive diagnosis of suspicious nipple abnormalities seen on breast imaging, avoiding surgery, and maintaining nipple integrity. In our population, 22% (2/9) of US-CBNs revealed malignancy.

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Indications and Techniques for Biopsy

Cited by 3 publications

References 53 publications

Radioguided occult lesion localisation: A retrospective audit at a single tertiary academic breast unit

Radioguided occult lesion localisation: A retrospective audit at a single tertiary academic breast unit

Primary/Neoadjuvant Treatments

Feasibility and Accuracy of Ultrasound-Guided Core Needle Biopsy for Nipple Lesions: A Pilot Study

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