Indications of inflammation visualized by ultrasound in osteoarthritis of the knee

Kristoffersen, H.; Torp‐Pedersen, Søren; Terslev, Lene; Qvistgaard, Étienne; Holm, C.; Ellegaard, Karen; Bliddal, Henning

doi:10.1080/02841850600551508

Cited by 45 publications

(22 citation statements)

References 28 publications

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“…Focussing in particular on the pathology imaged, the definitions used, scoring systems and their metric properties, results show that only a minority of works used US for assessing structural damage in OA [15, [23][24][25]. Even fewer publications have analysed the role of Doppler and contrast agents [34,[42][43][44][45]. Work performed until now demonstrates high variability not only in the pathology assessed but also in clear definition and grading of pathology.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Appropriate grayscale and power Doppler settings are reported in Table 2. Even in OA as well as in inflammatory arthritis, Doppler techniques consent to demonstrate local hyperaemia due to active synovial inflammation [42][43][44][45]. A fundamental aspect when using Doppler modalities consists of the application of the optimal setting, which markedly improves the capacities of US in detecting increased flow in inflammatory pathological conditions [41].…”

Section: Equipmentmentioning

confidence: 99%

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Imaging the joint in osteoarthritis: a place for ultrasound?

Iagnocco

2010

Best Practice & Research Clinical Rheumatology

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Ultrasound (US) is a valuable tool for imaging musculoskeletal changes in osteoarthritis. It shows early and late findings related to inflammation and structural damage. Sonography is a safe tool, which has recently registered an increasing and widespread use, it being considered as a bedside procedure in the clinical assessment of rheumatic patients. Its applications in osteoarthritis are related to easy accessibility of equipment, low cost, short duration of single examinations and the possibility of performing a multiregional joint evaluation in the same scanning session. Permitting an extensive evaluation of most joint changes present in osteoarthritis, it gives the opportunity to monitor disease progression and perform a follow-up of the response to different local and systemic treatments. US-guided procedures are commonly performed with safety, reliability and optimal patient tolerance. Development in technology and technique with improvement of new research studies will further amplify the diagnostic role of ultrasound in osteoarthritis in the near future. (C) 2009 Elsevier Ltd. All rights reserved

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Section: Literature Reviewmentioning

confidence: 99%

Section: Equipmentmentioning

confidence: 99%

Imaging the joint in osteoarthritis: a place for ultrasound?

Iagnocco

2010

Best Practice & Research Clinical Rheumatology

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“…3) [Keen et al, 2009;D'Agostino et al, 2005]. Synovitis detected with HRMSUS is a common finding in patients with knee OA ranging from 50% to 100%, depending on the study , Kristoffersen et al, 2006.…”

Section: Synovitismentioning

confidence: 98%

High‐resolution ultrasound in monitoring patients with osteoarthritis

Möller¹,

Bong²

2011

Drug Development Research

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The development of high‐resolution musculoskeletal ultrasound (US) has improved our ability to evaluate the structural and inflammatory pathology involving the articular cartilage and cortical bony surface of joints affected by osteoarthriris (OA). US has also allowed us to “visualize” the surrounding soft tissues ranging from synovium, joint capsule and retinacular supporting tissue to tendons, ligaments and nerves, and this, in turn, has given us a much more complete picture of the extent of damage caused by OA, the most common of all types of arthritis. As a result, it appears that inflammation of the synovium is a relevant feature in patients with OA. Early osteophytic bone changes at the interface of the joint capsule with the bony articular margin, degeneration of the articular cartilage and erosions including central erosion of erosive OA are the cardinal features of this disease and are all detected by HRMSUS. HRMSUS is effective in monitoring patients with OA and continues to evolve from a technical standpoint. Drug Dev Res 72:764–771, 2011. © 2011 Wiley Periodicals, Inc.

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“…A small to moderate amount of synovitis and effusion were observed in OA (for example -47% -100% of the patients have synovitis and/or effusion in the symptomatic OA knee) [10]. US can detect minimal synovitis in a joint and to identify patients with a higher risk of progression [11].…”

Section: Introductionmentioning

confidence: 99%

“…Advantages of US assessments are the early detection of the structural changes of bone surface and the inflammatory changes inside the joint, and the excellent monitoring of subtle progression [10]. Synovitis or joint effusion detected by US correlated to pain in knee OA, magnetic resonance imaging, and arthroscopic findings [12].…”

Section: Introductionmentioning

confidence: 99%

Correlation between protein YKL-40 and ultrasonographic findings in active knee osteoarthritis

et al. 2018

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The aim of our study was to analyze the level of the glycoprotein YKL-40 in patients with active knee osteoarthritis (OA) and to search possible correlations with local inflammation and ultrasound (US) findings.Material and methods: A prospective study with fifty consecutive patients with active knee OA (diagnosed based on the American College of Rheumatology criteria for OA with radiographic confirmation) was performed. Concentrations of YKL-40 in serum and synovial fluid were measured by ELISA. US examinations – Gray scale (GS) US and Power Doppler (PD) US – of the knee was performed according to international guidelines. The suprapatellar, medial and lateral parapatellar recesses were scanned in each knee to evaluate synovial hypertrophy and vascularization.Results: Forty women (mean age 61.50±11.33 years old) and 10 men (aged 68.50±6.60 years old) were enrolled. We found that the synovial level of the glycoprotein (237.80±104.08 ng/ml) was significantly higher compared to the serum concentration (112.83±60.61 ng/ml, p<0.001). The serum concentration in OA patients was higher comparing with age-matched healthy controls (84.19±11.39 ng/ml) (p<0.05). A statistically significant association between YKL- 40 in synovial fluid and serum levels was shown. We determined a moderately positive linear relationship between the synovial level of the glycoprotein and the serum concentration. No association between the levels of inflammatory markers – erythrocyte sedimentation rate and C-reactive protein – and YKL-40 concentrations was detected. Our study revealed a strong relationship between YKL-40 in synovial fluid and GS US and feeble with PD US. YKL-40 correlated with inflammatory activity in knee joints and neovascularization detected by US.Conclusions: YKL-40 is involved in the pathogenesis of OA synovitis. Evaluation of YKL-40 levels in parallel with US might provide more sensitive and reliable information for the diagnosis and understanding of OA.

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Indications of inflammation visualized by ultrasound in osteoarthritis of the knee

Abstract: The finding in the majority of cases of both effusions on B-mode US and Doppler activity confirms that there is a varying degree of inflammation in knee OA as diagnosed by the ACR criteria.

Cited by 45 publications

References 28 publications

Imaging the joint in osteoarthritis: a place for ultrasound?

Imaging the joint in osteoarthritis: a place for ultrasound?

High‐resolution ultrasound in monitoring patients with osteoarthritis

Correlation between protein YKL-40 and ultrasonographic findings in active knee osteoarthritis

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