2020
DOI: 10.32014/2020.2518-1467.139
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Indicators of Cell Metabolism in Vitro in Researches of Anti-Inflammatory and Cytotoxic Effects of Fulleropyrrolidines С60 and Their Initial Substrates

Abstract: The article considers data on the in vitro study of new fulleropyrrolidine compounds for anti-inflammatory and cytotoxic activity in cultures of human monocyte cell lines MonoMac-6 and THP-1Blue and also as inhibitors of human neutrophil elastase. This enzyme is a regulator of inflammation. In different situations, it can act both as a pro-inflammatory and as an anti-inflammatory agent. An imbalance in the regulation of elastase activity plays an important role in the pathogenesis of cystic fibrosis, acute res… Show more

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