Índice triglicéridos y glucosa: un indicador útil de insulinorresistencia

Unger, Gisela; Benozzi, Silvia Fabiana; ̈Perruzza, Fernando; Pennacchiotti, Graciela Laura

doi:10.1016/j.endonu.2014.06.009

Cited by 176 publications

(32 citation statements)

References 20 publications

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“…17 TyG was calculated using the equation: Ln [TG (mg/dL) × glucose (mg/dL)/2. 18,19 HOMA was calculated using the formula: fasting glucose 9mg/dL × fasting insulin (uU/mL)/405. 20…”

Section: Data Collectionmentioning

confidence: 99%

<p>Adiposity Indicators as Cardio-Metabolic Risk Predictors in Adults from Country with High Burden of Obesity</p>

Kerkadi¹,

Suleman²,

Salah³

et al. 2020

DMSO

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Background: In Qatar more than 70% 0f the adults are overweight and obese. Different adiposity assessment methods have been proposed to identify individuals at cardio-metabolic risk. Purpose: This study aimed to compare anthropometric indicators with Dual-energy X-ray absorptiometry (DXA)-derived adiposity indicators in predicting cardio-metabolic risk among Qatari adults. Patients and Methods: A random sample of five hundred and fifty-eight (558) healthy Qatari adults (men and women) aged 20 to 50 years was obtained from Qatar Biobank survey data. Anthropometric data (weight, height, and waist circumference), the DXAderived data, and cardio-metabolic (CM) risk parameters were analyzed. A Spearman partial correlation coefficient, Receiver Operating Characteristics (ROC) curve and an area under curve (AUC) were used to assess the predicting ability of adiposity indicators for CM risk factors. Results: Adiposity indices (anthropometric and DXA) were significantly correlated with most of the CM indicators (r= −0.292 to 0.486, p< 0.001). The AUC of waist to height ratio (WHtR) was significantly higher than that of body mass index (BMI) and waist circumference (WC) in the prediction of low high density lipoprotein (HDL) (AUC=0.65, AUC=0.59; AUC=0.64), high low density lipoprotein (LDL) (AUC=0.67; AUC=0.62; AUC=0.66), high cholesterol (AUC=0.66; AUC=0.63; AUC=0.63), and high Homeostatic Model Assessment-(HOMA) (AUC= 0.81; AUC= 0.78; AUC=0.78). Among DXA-parameters, trunk fat had the highest AUCs for total cholesterol (AUC= 0.64, CI=0.56, 0.73), triglycerides and glucose index (TyG) (AUC=0.69, CI=0.64, 0.74), and HOMA (AUC=0.78, CI= 0.73, 0.84). Conclusion: Results of the present study show that adiposity indicators (WC and WHtR) are clinically valuable tools to identify individuals at risk of CVD compared to DXA-derived parameters, while DXA can provide more accurate estimates.

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“…17 TyG was calculated using the equation: Ln [TG (mg/dL) × glucose (mg/dL)/2. 18,19 HOMA was calculated using the formula: fasting glucose 9mg/dL × fasting insulin (uU/mL)/405. 20…”

Section: Data Collectionmentioning

confidence: 99%

<p>Adiposity Indicators as Cardio-Metabolic Risk Predictors in Adults from Country with High Burden of Obesity</p>

Kerkadi¹,

Suleman²,

Salah³

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…Recently, the triglyceride and glucose (TyG) index has been proposed as a simple surrogate of insulin resistance (IR) [ 8 , 9 ], and numerous studies have also found a relationship between HTN and IR [ 10 , 11 ]. Additionally, a recent cross-sectional study revealed that the TyG index is closely associated with HTN [ 12 ]; however, the longitudinal association remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Triglyceride and glucose (TyG) index as a predictor of incident hypertension: a 9-year longitudinal population-based study

2017

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BackgroundHypertension and the triglyceride and glucose index both have been associated with insulin resistance; however, the longitudinal association remains unclear. This study was designed to investigate the longitudinal association between the triglyceride and glucose index and incident hypertension among the Chinese population.MethodsWe studied 4686 subjects (3177 males and 1509 females) and followed up for 9 years. The subjects were divided into four groups based on the triglyceride and glucose index. Univariate and multivariate Cox regression models were used to analyse the risk factors of hypertension.ResultsAfter 9 years of follow-up, 2047 subjects developed hypertension. The overall 9-year cumulative incidence of hypertension was 43.7%, ranging from 28.5% in quartile 1 to 36.9% in quartile 2, 49.2% in quartile 3 and 59.8% in quartile 4 (p for trend < 0.001). Cox regression analyses indicated that higher triglyceride and glucose index was associated with an increased risk of subsequent incident hypertension.ConclusionThe triglyceride and glucose index can predict the incident hypertension among the Chinese population.

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“…Instead, indirect index, such as the homeostasis model assessment of IR (HOMA-IR), is widely used clinically 17) . Based on the findings that elevation of serum triglyceride (TG) is related to a decrease in insulin sensitivity 18) by interfering with muscle glucose metabolism 19) , another indirect index, the TG and glucose index (TyG index), has been used in some adult studies 20 21 22) . The TyG index is based on fasting TG and glucose instead of fasting insulin and glucose.…”

Section: Introductionmentioning

confidence: 99%

The cutoff values of indirect indices for measuring insulin resistance for metabolic syndrome in Korean children and adolescents

Kim

Park

Kim

et al. 2016

Ann Pediatr Endocrinol Metab

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PurposeThe prevalence rates of metabolic syndrome (MetS) and percentile distribution of insulin resistance (IR) among Korean children and adolescents were investigated. The cutoff values of IR were calculated to identify high-risk MetS groups.MethodsData from 3,313 Korean subjects (1,756 boys and 1,557 girls, aged 10–18 years) were included from the Korean National Health and Nutrition Examination Survey conducted during 2007–2010. Three different sets of criteria for MetS were used. Indirect measures of IR were homeostasis model assessment (HOMA-IR) and triglyceride and glucose (TyG) index. The cutoff values of the HOMA-IR and TyG index were obtained from the receiver operation characteristic curves.ResultsAccording to the MetS criteria of de Ferranti el al., Cook et al., and the International Diabetes Federation, the prevalence rates in males and females were 13.9% and 12.3%, 4.6% and 3.6%, and 1.4% and 1.8%, respectively. Uses these 3 criteria, the cutoff values of the HOMA-IR and TyG index were 2.94 and 8.41, 3.29 and 8.38, and 3.54 and 8.66, respectively. The cutoff values using each of the 3 criteria approximately corresponds to the 50th–75th, 75th, and 75th–90th percentiles of normal HOMA-IR and TyG index levels.ConclusionThis study describes the prevalence rates of MetS in Korean children and adolescents, an index of IR, and the cutoff values for MetS with the aim of detecting high-risk groups. The usefulness of these criteria needs to be verified by further evaluation.

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Índice triglicéridos y glucosa: un indicador útil de insulinorresistencia

Cited by 176 publications

References 20 publications

<p>Adiposity Indicators as Cardio-Metabolic Risk Predictors in Adults from Country with High Burden of Obesity</p>

<p>Adiposity Indicators as Cardio-Metabolic Risk Predictors in Adults from Country with High Burden of Obesity</p>

Triglyceride and glucose (TyG) index as a predictor of incident hypertension: a 9-year longitudinal population-based study

The cutoff values of indirect indices for measuring insulin resistance for metabolic syndrome in Korean children and adolescents

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