Indices of oxidative stress in pregnancy with fetal growth restriction

Karowicz-Bilińska, Agata; Kędziora–Kornatowska, Kornelia; Bartosz, Grzegorz

doi:10.1080/10715760701291647

Cited by 66 publications

(45 citation statements)

References 30 publications

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“…In the absence of fetal genetic abnormalities, IUGR is often ascribed to placental insufficiency (Wareing et al, 2006), because it is often associated with extensive atherosclerotic and thrombotic lesions in the placental arteries and with placental infarction (Stuart et al, 1981). Placental oxidative stress, defective trophoblast invasion of arterioles, and RUPP similar to that seen in PE may be the underlying pathogenic mechanisms of both idiopathic IUGR and PE/IUGR pregnancies (Figueroa and Maulik, 2006;Karowicz-Bilinska et al, 2007).…”

Section: B Prostacyclin Metabolism and Intrauterine Growth Restrictionmentioning

confidence: 99%

Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn

2012

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Section: B Prostacyclin Metabolism and Intrauterine Growth Restrictionmentioning

confidence: 99%

Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn

2012

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“…Dysfunctions of several molecules, such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, alpha-1-antitrypsin (SERPINA1), insulin-like growth factor (IGF) and vascular endothelial growth factor (VEGF), might correlate with abnormal trophoblast invasion and vascular development, and oxidative stress in the placenta of FGR subjects [16,17,18,19,20,21,22]. The expression levels of apoptosis associated factors, such as ATP-dependent RNA helicase (DDX42), Bcl-2, p53, low-density lipoprotein (LDL), apo B and matrix metalloproteinases, changed during FGR development [6,23,24,25,26,27,28].…”

Section: Introductionmentioning

confidence: 99%

Comparative Proteomic Profile of the Human Placenta in Normal and Fetal Growth Restriction Subjects

Miao

Chen

Wang

et al. 2014

Cell Physiol Biochem

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Background: Fetal growth restriction (FGR) is the main cause of intrauterine fetal death and the second leading cause of death in the neonatal period. A large body of evidence suggests that FGR may be associated with the placenta, although its etiology and pathogenesis remain to be fully elucidated. Methods and Results: To better understand the molecular mechanisms underlying the pathological development of the placenta in FGR, we used tandem mass tags (TMTs) to construct a large-scale comparative proteomic profile of human placentas from normal and FGR pregnancies. A total of 1,198 kinds of proteins were identified in the control and FGR placentas, of which 95 were differentially expressed between two groups. Ingenuity Pathway Analysis (IPA) was used to organize these differentially expressed proteins into networks of interacting proteins and to identify the modules of functionally related proteins. Western blotting was used to verify the expression patterns of several randomly selected proteins. Conclusion: The placentas of women with FGR displayed significant proteome differences compared with normal pregnancy. The results indicate that a variety of mechanisms and proteins may contribute to the development of FGR. Further studies and validations are required to elucidate the exact roles of these proteins in FGR pathogenesis.

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“…Increased levels of oxidative stress have been described in serum of pregnant women with IUGR [6]. In fact, the blood plasma levels of TBARS from Pregnant women with IUGR were significantly increased as compared with control pregnant women (gestational control, 2.38±0.17 nmoles MDA/ml plasma vs IUGR, 5.32 ± 0.49 nmoles MDA/ ml plasma, n=10, p<0.001).…”

Section: Resultsmentioning

confidence: 79%

“…It has also been reported that oxidative DNA damage is increased in IUGR placenta [5]. Furthermore, other authors have shown increased levels of lipid peroxidation (TBARS, conjugated dienes and lipid peroxides) and decreased antioxidant capacity in serum of pregnant women with IUGR [6].…”

Section: Introductionmentioning

confidence: 89%

“…Pregnant women with IUGR has been shown to develop increased levels of oxidative stress in placenta [5] and amniotic fluid [22], as well as a decreased quantity of enzymatic antioxidants in their cord blood [1], as compared to control pregnant women. Karowicz-Bilinska et al [6] found an elevated oxidative stress in blood serum of pregnant women with IUGR and a decreased total antioxidant capacity of the serum as compared to healthy pregnant women. This is in agreement with our results showing increased levels of TBARS (Table 1) Elevated levels of plasma lipid peroxidation can spread the oxidative stress through the entire organism.…”

Section: Conjugated Dienesmentioning

confidence: 99%

See 1 more Smart Citation

IUGR, lipid peroxidation, and calcium ATPase activity of maternal red blood cell ghosts

Malpica¹,

Piñero²,

Chiarello³

et al. 2017

J Pregnancy Reprod

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Intrauterine growth restriction (IUGR) leads to developmental disorders and deaths among neonates. There is strong evidence of oxidative stress in newborns, as well as in placenta of pregnant women with IUGR. Maternal red blood cells can be peroxidized as they pass through the placenta, which might induce alterations reducing their fluidity and, consequently, increasing their fragility to osmotic changes and inhibiting the activity of membrane-bound enzymes, such as the Ca-ATPase.Objective: To determine osmotic fragility, lipid peroxidation levels and Ca-ATPase activity of red blood cell ghosts from pregnant women with intrauterine growth restriction in their third trimester of gestation.Methodology: Venous blood was drawn from pregnant women, either with IUGR or controls. Osmotic fragility of the red cells, as well as lipid peroxidation (TBARS and conjugated dienes) and Ca-ATPase activity of their membranes were determined.Results: It was found a higher level of osmotic fragility and lipid peroxidation, as well as a lower Ca-ATPase activity of red blood cells from the pregnant women with IUGR, as compared to control pregnant women. Conclusion:There is a clear relationship between IUGR and higher levels of osmotic fragility and lipid peroxidation, as well as a lower Ca-ATPase activity of red blood cells.

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Indices of oxidative stress in pregnancy with fetal growth restriction

Cited by 66 publications

References 30 publications

Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn

Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn

Comparative Proteomic Profile of the Human Placenta in Normal and Fetal Growth Restriction Subjects

IUGR, lipid peroxidation, and calcium ATPase activity of maternal red blood cell ghosts

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