IUGR, lipid peroxidation, and calcium ATPase activity of maternal red blood cell ghosts

Abstract

Intrauterine growth restriction (IUGR) leads to developmental disorders and deaths among neonates. There is strong evidence of oxidative stress in newborns, as well as in placenta of pregnant women with IUGR. Maternal red blood cells can be peroxidized as they pass through the placenta, which might induce alterations reducing their fluidity and, consequently, increasing their fragility to osmotic changes and inhibiting the activity of membrane-bound enzymes, such as the Ca-ATPase.Objective: To determine osmotic fragility, lipid peroxidation levels and Ca-ATPase activity of red blood cell ghosts from pregnant women with intrauterine growth restriction in their third trimester of gestation.Methodology: Venous blood was drawn from pregnant women, either with IUGR or controls. Osmotic fragility of the red cells, as well as lipid peroxidation (TBARS and conjugated dienes) and Ca-ATPase activity of their membranes were determined.Results: It was found a higher level of osmotic fragility and lipid peroxidation, as well as a lower Ca-ATPase activity of red blood cells from the pregnant women with IUGR, as compared to control pregnant women. Conclusion:There is a clear relationship between IUGR and higher levels of osmotic fragility and lipid peroxidation, as well as a lower Ca-ATPase activity of red blood cells.

Glutathione and oxidized nicotinamide adenine dinucleotide (NAD+) redox status in plasma and placental tissue of Saudi patients with intrauterine growth restriction

“… 25 Similarly, the enhanced lipid peroxidation and diminished antioxidant status observed are consistent with the results of recent studies. 26 Hence, the literature and this study unanimously indicate lipid peroxide products as prominent risk factors of OS and IUGR.…”