2011
DOI: 10.1080/15287394.2011.615107
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Indigenous American Ancestry is Associated with Arsenic Methylation Efficiency in an Admixed Population of Northwest Mexico

Abstract: Many studies provide evidence relating lower human arsenic (As) methylation efficiency, represented by high % urinary monomethylarsonic acid (MMA(V)), with several arsenic-induced diseases, possibly due to the fact that MMA(V) serves as a proxy for MMA(III), the most toxic arsenic metabolite. Some epidemiological studies have suggested that indigenous Americans (AME) methylate As more efficiently, however data supporting this have been equivocal. The aim of this study was to characterize the association betwee… Show more

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Cited by 23 publications
(16 citation statements)
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“…Nongenetic factors could result in false positives in a linkage study if they mimic Mendelian patterns, an unlikely occurrence. Regarding indigenous American ancestry, our findings are consistent with those from Andean (Engstrom et al 2010; Hopenhayn-Rich et al 1996b; Vahter et al 1995) and Northwest Mexican (Gomez-Rubio et al 2012) communities characterized by higher %DMA in urine compared with populations in Europe and Asia (Chiou et al 1997; Gamble et al 2005; Kile et al 2011; Lindberg et al 2007). The different arsenic methylation profile in American Indian populations could be partly genetically determined.…”
Section: Discussionsupporting
confidence: 87%
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“…Nongenetic factors could result in false positives in a linkage study if they mimic Mendelian patterns, an unlikely occurrence. Regarding indigenous American ancestry, our findings are consistent with those from Andean (Engstrom et al 2010; Hopenhayn-Rich et al 1996b; Vahter et al 1995) and Northwest Mexican (Gomez-Rubio et al 2012) communities characterized by higher %DMA in urine compared with populations in Europe and Asia (Chiou et al 1997; Gamble et al 2005; Kile et al 2011; Lindberg et al 2007). The different arsenic methylation profile in American Indian populations could be partly genetically determined.…”
Section: Discussionsupporting
confidence: 87%
“…Determinants of arsenic metabolism include sex, smoking, alcohol intake, nutritional status, BMI, and race/ethnicity (Gamble et al 2005; Gomez-Rubio et al 2011, 2012; Hopenhayn-Rich et al 1996a; Hsueh et al 2003; Navas-Acien et al 2009; Steinmaus et al 2005). Men, smokers, people who drink alcohol, and people with nutritional deficiencies have higher %MMA and lower %DMA in urine (Gamble et al 2005; Hsueh et al 2003; Navas-Acien et al 2009).…”
Section: Discussionmentioning
confidence: 99%
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“…Hopenhayn-Rich et al (1996) reported more efficient arsenic methylation in persons of Atacameño ethnicity (12.6% MMA in urine), compared with those of European ancestry on the Chilean side of the Andes highlands (17.2%, p < 0.001 between groups). Furthermore, Mexican populations of indigenous American ancestry that live in areas with historically high arsenic content have repeatedly been shown to have lower urinary percent MMA compared with populations of European ancestry (Gomez-Rubio et al 2010, 2012; Meza et al 2005). In addition, the frequency of protective AS3MT genotypes was higher in the Mexican populations than in the European populations.…”
Section: Discussionmentioning
confidence: 99%