Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer

Abstract

Background:Peptic ulcer disease (PUD), encompassing gastric and duodenal ulcers is the most prevalent gastrointestinal disorder. The pathophysiology of PUD involves an imbalance between offensive factors like acid, pepsin and defensive factors like nitric oxide and growth factors. The clinical evaluation of antiulcer drugs showed tolerance, incidence of relapses and side-effects that make their efficacy arguable. An indigenous drug like Musa sapientum possessing fewer side-effects is the major thrust area of present day research, aiming at a better and safer approach for the management of PUD.Material and Methods:The unripe plantain bananas (Musa sapientum) were shade-dried, powdered and used for phytochemical analysis and as antiulcer drug. In our present study Group I rats served as control and were treated with saline, Group II was indomethacin-induced ulcerated rats, Group III received aqueous extract of Musa sapientum along with indomethacin and Group IV received esomeprazole along with indomethacin for 21 days. The anti-ulcerogenic activity was investigated by performing hematological, mucosal, antioxidant profile in comparison with the standard drug esomeprazole.Results:Our findings from High - Performance Thin Layer Chromatography (HPTLC) analysis showed that Musa sapientum has an active compound a monomeric flavonoid (leucocyanidin) with anti-ulcerogenic activity. Results were expressed as mean ± SD. All our results are in congruous with the results of standard drug esomeprazole.Conclusion:It could be clearly concluded that administration of the aqueous extract of Musa sapientum at the dose used in this study tends to ameliorate ulcers. Its use in indigenous medicine should be scientifically scrutinized with further research.

Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: cytokines and growth factor by PCR amplification

“…The finger printing of High-Performance Thin-Layer Chromatography (HPTLC) chromatogram showed the presence of at least eight active compounds (Figure 1 ). The analysis of retention factor and colors of the resolved bands at 254 nm at R f 0.71 in MSE could be a flavonoid, leucocyanidin as earlier reported by Prabha and associates [ 17 ] where they have shown the similar result with the methanolic extract of Musa sapientum fruit.…”

“…Flavonoids are most commonly known for their antiulcer activity, lipid lowering activity, anti-inflammatory activity, antioxidant activity, antimicrobial activity [ 31 ] and anti-hyperglycaemic [ 32 ] activities. HPTLC fingerprinting of MSE demonstrated eight active constituents where one of the constituents may be leucocyanidin, as reported earlier by Prabha and associates [ 17 ], who have compared the constituent with authenticated standard leucocyanidin. Alkaloids have been reported to show anti-diabetic and anti-inflammatory, antioxidant activity [ 33 ] while saponins showed anti-diabetic effects [ 34 ].…”

“…Hypoglycemic activity has been reported from green fruit of plantain banana. Further, leucocyanidin, a flavonoid, was isolated from plantain banana and its dimethoxy derivative, leucocyanidin 3-O-beta-D-galactosyl cellobioside, demonstrated hypoglycemic effect in experimental animal [ 16 , 17 ]. Therefore, the present study was extended to evaluate the healing effects of MSE (test drug) in acetic acid-induced gastric ulcer in diabetic (DR-AA) rat and its effects on TNF-α, IL-1β and TGF-α.…”

Musa sapientum with exercises attenuates hyperglycaemia and pancreatic islet cells degeneration in alloxan-diabetic rats.

“…Significant antioxidant properties have been observed in investigations of peel extracts [ 3 ], inflorescence and stalk [ 4 ] of M. sapientum . Its banana pulps [ 5 ] and unripe plantain bananas [ 6 ] have been reported to have anti-ulcerogenic properties; its seeds possess antioxidant, anti-diarrheal, and anti-microbial activities [ 7 ], its flowers possess hypoglycemic activities [ 8 ] while its sucker possesses hypoglycemic [ 9 ] and anti-ulcerogenic [ 2 ] potentials.…”

Gastro Protective and Antioxidant Effect of Euphorbia Prostrata Against Indomethacin Induced Gastric Ulcers in Healthy Adult Male Albino Rabbits

“…Gastric mucosa is the layer that covers the stomach protecting it from various agents such as acid, pepsin and different drugs 2 . Gastric mucosal layer can be damaged by the alteration between various offensive and defensive factors in the stomach 3 . The offensive factors include the secretion of acid and pepsin, Helicobacter pylori infection and bile salts whereas the defensive factors includes the prostaglandins, mucus secretion, blood flow and cellular regeneration 4 .…”