Indirect Burst Pressure Measurements for the Mechanical Assessment of Biological Vessels

Geelhoed, Wouter J.; Lalai, Reshma; Sinnige, Joep H.; Jongeleen, Patrick J.; Storm, Cornelis; Rotmans, Joris I.

doi:10.1089/ten.tec.2019.0133

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…Mechanical stability of decellularized vessels was decreased compared to native vessels, but still exceeded the systolic physiological pressure of 120 mm Hg (Figure 3). Similar values were observed for both native bovine and porcine carotid arteries in direct and indirect burst pressure measurements 41,42 . Geelhoed et al previously declared that a direct method, such as a pressurized burst pressure test using a whole vessel segment, is advantageous compared to the method of applying pressure to a segment of opened and flattened out vessels (indirect method) used in this study.…”

Section: Discussionsupporting

confidence: 82%

“…Similar values were observed for both native bovine and porcine carotid arteries in direct and indirect burst pressure measurements. 41,42 Geelhoed et al previously declared that a direct method, such as a pressurized burst pressure test using a whole vessel segment, is advantageous compared to the method of applying pressure to a segment of opened and flattened out vessels (indirect method) used in this study. However, it should be noted, that the retrieved values in this study using an indirect methods are still above the physiological values, even if the indirect method overestimates the burst pressure value by factor 2.…”

Section: Discussionmentioning

confidence: 86%

“…However, it should be noted, that the retrieved values in this study using an indirect methods are still above the physiological values, even if the indirect method overestimates the burst pressure value by factor 2. 41 For the evaluation of mechanical stability, in vivo animal experiments should be performed in future.…”

Section: Discussionmentioning

confidence: 99%

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Re‐endothelialization of non‐detergent decellularized porcine vessels

et al. 2020

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The optimal vascular graft should exhibit sufficient mechanical strength, low immunogenicity, high biocompatibility, and resistance to calcification, thrombosis, stenosis, and infection. 1 From a surgical perspective, it should be easy to handle, have reasonable manufacturing costs, and be readily available. Large diameter vascular grafts (>5 mm luminal diameter) have been successfully developed, but smaller vascular grafts (<5 mm luminal diameter) are difficult to generate because of blood clotting, scarring, or occlusion after implantation. 1 The materials used to construct vascular grafts fall into two categories: synthetic or biologic. 2 Synthetic scaffolds are either made from nondegradable polymers such as polytetrafluoroethylene and Dacron, which are widely used in the clinic, or biodegradable polymers such as poly(lactic-acid) and poly(glycolic-acid). 1,2 Synthetic scaffolds are advantageous with respect to the manufacturing process providing reproducible properties such as mechanical strength, size, and configuration. 1 However, current synthetic models are unable to actively respond to cellular signals and often lack the ability to host cell attachment or growth. 3,4 Biologic scaffolds are

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 86%

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Re‐endothelialization of non‐detergent decellularized porcine vessels

et al. 2020

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“…Results showed a significant increase of burst strength on the sinuses compared to the walls for all scaffold groups (Figure 3). Although to the best of our knowledge, there are no data in the literature on the difference of burst strength between the wall and SV, higher tensile stiffness of SV (Azadani et al, 2012) suggests a higher burst strength according to a number of studies that correlate tensile stiffness to burst strength (Laterreur et al, 2014;Geelhoed et al, 2019). This is in agreement with our burst strength results presented for the wall and SV of MEW/fibrin scaffolds.…”

Section: Fabrication Of Anatomically Relevant Aortic Root Scaffoldssupporting

confidence: 91%

Melt Electrowriting of Complex 3D Anatomically Relevant Scaffolds

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et al. 2020

Front. Bioeng. Biotechnol.

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“…Therefore, direct burst pressure measurement might be more practical to assess the mechanical reliability than the theoretical burst pressure calculated from the UTS value. Recently, indirect burst pressure and direct burst pressure of synthetic material tubes, native vessels, and TEVGs were compared [17]. They noted that indirect burst pressure obtained from UTS was well correlated to the direct burst pressure in the synthetic materials.…”

Section: Plos Onementioning

confidence: 99%

Modifications of the mechanical properties of in vivo tissue-engineered vascular grafts by chemical treatments for a short duration

et al. 2021

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In vivo tissue-engineered vascular grafts constructed in the subcutaneous spaces of graft recipients have functioned well clinically. Because the formation of vascular graft tissues depends on several recipient conditions, chemical pretreatments, such as dehydration by ethanol (ET) or crosslinking by glutaraldehyde (GA), have been attempted to improve the initial mechanical durability of the tissues. Here, we compared the effects of short-duration (10 min) chemical treatments on the mechanical properties of tissues. Tubular tissues (internal diameter, 5 mm) constructed in the subcutaneous tissues of beagle dogs (4 weeks, n = 3), were classified into three groups: raw tissue without any treatment (RAW), tissue dehydrated with 70% ET (ET), and tissue crosslinked with 0.6% GA (GA). Five mechanical parameters were measured: burst pressure, suture retention strength, ultimate tensile strength (UTS), ultimate strain (%), and Young’s modulus. The tissues were also autologously re-embedded into the subcutaneous spaces of the same dogs for 4 weeks (n = 2) for the evaluation of histological responses. The burst pressure of the RAW group (1275.9 ± 254.0 mm Hg) was significantly lower than those of ET (2115.1 ± 262.2 mm Hg, p = 0.0298) and GA (2570.5 ± 282.6 mm Hg, p = 0.0017) groups. Suture retention strength, UTS or the ultimate strain did not differ significantly among the groups. Young’s modulus of the ET group was the highest (RAW: 5.41 ± 1.16 MPa, ET: 12.28 ± 2.55 MPa, GA: 7.65 ± 1.18 MPa, p = 0.0185). No significant inflammatory tissue response or evidence of residual chemical toxicity was observed in samples implanted subcutaneously for four weeks. Therefore, short-duration ET and GA treatment might improve surgical handling and the mechanical properties of in vivo tissue-engineered vascular tissues to produce ideal grafts in terms of mechanical properties without interfering with histological responses.

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Indirect Burst Pressure Measurements for the Mechanical Assessment of Biological Vessels

Cited by 11 publications

References 18 publications

Re‐endothelialization of non‐detergent decellularized porcine vessels

Re‐endothelialization of non‐detergent decellularized porcine vessels

Melt Electrowriting of Complex 3D Anatomically Relevant Scaffolds

Modifications of the mechanical properties of in vivo tissue-engineered vascular grafts by chemical treatments for a short duration

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