Indirect calorimetry: methodology, instruments and clinical application

Rocha, Eduardo Eiras Moreira da; Alves, Valéria Girard Fabiano; Fonseca, Rosana Barcellos Vieira da

doi:10.1097/01.mco.0000222107.15548.f5

Cited by 145 publications

(121 citation statements)

References 52 publications

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“…One of our most important findings is that a resuscitated rat can sustain RQs outside of the commonly cited range of 0.7 to 1.0. RQ values <0.7 are often considered to be in error 30, 31, 32, 33. Oshima et al32 reported 7 cases of CA in which energy expenditures were found to be unexpectedly high in the post‐ROSC period, but excluded measurements when the RQ was lower than 0.7.…”

Section: Discussionmentioning

confidence: 99%

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Dissociated Oxygen Consumption and Carbon Dioxide Production in the Post–Cardiac Arrest Rat: A Novel Metabolic Phenotype

Shinozaki

Becker

Saeki³

et al. 2018

JAHA

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BackgroundThe concept that resuscitation from cardiac arrest (CA) results in a metabolic injury is broadly accepted, yet patients never receive this diagnosis. We sought to find evidence of metabolic injuries after CA by measuring O2 consumption and CO2 production (VCO 2) in a rodent model. In addition, we tested the effect of inspired 100% O2 on the metabolism.Methods and ResultsRats were anesthetized and randomized into 3 groups: resuscitation from 10‐minute asphyxia with inhaled 100% O2 (CA–fraction of inspired O2 [FIO2] 1.0), with 30% O2 (CA‐FIO 2 0.3), and sham with 30% O2 (sham‐FIO 2 0.3). Animals were resuscitated with manual cardiopulmonary resuscitation. The volume of extracted O2 (VO 2) and VCO 2 were measured for a 2‐hour period after resuscitation. The respiratory quotient (RQ) was RQ=VCO 2/VO 2. VCO 2 was elevated in CA‐FIO 2 1.0 and CA‐FIO 2 0.3 when compared with sham‐FIO 2 0.3 in minutes 5 to 40 after resuscitation (CA‐FIO 2 1.0: 16.7±2.2, P<0.01; CA‐FIO 2 0.3: 17.4±1.4, P<0.01; versus sham‐FIO 2 0.3: 13.6±1.1 mL/kg per minute), and then returned to normal. VO 2 in CA‐FIO 2 1.0 and CA‐FIO 2 0.3 increased gradually and was significantly higher than sham‐FIO 2 0.3 2 hours after resuscitation (CA‐FIO 2 1.0: 28.7±6.7, P<0.01; CA‐FIO 2 0.3: 24.4±2.3, P<0.01; versus sham‐FIO 2 0.3: 15.8±2.4 mL/kg per minute). The RQ of CA animals persistently decreased (CA‐FIO 2 1.0: 0.54±0.12 versus CA‐FIO 2 0.3: 0.68±0.05 versus sham‐FIO 2 0.3: 0.93±0.11, P<0.01 overall).Conclusions CA altered cellular metabolism resulting in increased VO 2 with normal VCO 2. Normal VCO 2 suggests that the postresuscitation Krebs cycle is operating at a presumably healthy rate. Increased VO 2 in the face of normal VCO 2 suggests a significant alteration in O2 utilization in postresuscitation. Several RQ values fell well outside the normally cited range of 0.7 to 1.0. Higher FIO 2 may increase VO 2, leading to even lower RQ values.

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Section: Discussionmentioning

confidence: 99%

“…VO 2 and VCO 2 are calculated by the following equations29, 30:

V {normalO}_{2} = {normalV}_{normalI} \times FI {normalO}_{2} - {normalV}_{normalE} \times FE {normalO}_{2}

{VCO}_{2} = {normalV}_{normalI} \times {FICO}_{2} - {normalV}_{normalE} \times {FECO}_{2}

…”

Section: Methodsmentioning

confidence: 99%

Dissociated Oxygen Consumption and Carbon Dioxide Production in the Post–Cardiac Arrest Rat: A Novel Metabolic Phenotype

Shinozaki

Becker

Saeki³

et al. 2018

JAHA

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“…Oxygen consumption and CO 2 production were measured every minute for 30 min. REE was calculated according to Weir's equation (Weir, 1949) and expressed per 24 h (Da Rocha et al, 2006). Measured REE values were compared with the REE calculated with Harris-Benedict predictive equation, using current body weight.…”

Section: Methodsmentioning

confidence: 99%

Ghrelin and PYY3−36 in gastrectomized and vagotomized patients: relations with appetite, energy intake and resting energy expenditure

et al. 2010

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Background/Objectives: Reduced food intake, appetite loss and alteration of ghrelin and PYY 3À36 secretion have been suggested to have a function in the loss of body weight commonly observed after gastrectomy. The objective of this study was to investigate the circulating concentrations of ghrelin and PYY 3À36 and their relationships with food intake, appetite and resting energy expenditure (REE) after gastrectomy plus vagotomy. Subjects/Methods: Seven patients with total gastrectomy (TG), 14 with partial gastrectomy (PG) and 10 healthy controls were studied. Habitual food intake and REE was assessed; fasting and postprandial plasma total ghrelin, PYY 3À36 concentrations and appetite ratings were determined after ingestion of a liquid test meal. Results: Differently from PG and controls, fasting ghrelin correlated with REE, and a higher energy intake was observed in the TG group. Fasting plasma ghrelin concentrations were lower in TG compared with controls, and no ghrelin response to the meal was observed in either PG or TG. Fasting plasma PYY 3À36 concentrations were not different among the groups. There was an early and exaggerated postprandial rise in PYY 3À36 levels in both PG and TG groups, but not in controls. No effect of ghrelin or PYY 3À36 concentrations was observed on hunger, prospective consumption or fullness ratings. Conclusions: Total ghrelin and PYY 3À36 do not seem to be involved with appetite or energy intake regulation after gastrectomy plus vagotomy. Ghrelin secreted by sources other than stomach is likely to have a function in the long-term regulation of body weight after TG.

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“…The most common method of carrying out such determinations is by indirect calorimetry. Indirect calorimetry, the determination of airway carbon dioxide elimination (VCO2) and oxygen uptake (VO2), can be used to non-invasively detect non-steady state perturbations of gas kinetics and mirror tissue metabolism [11,32].…”

Section: Definition Of Indirect Calorimetrymentioning

confidence: 99%

Historical Development of Nutrient and Calorimetry and Expired Gas Analysis Indirect Calorimetry

Yoon¹,

Kim²,

Kim³

2010

Journal of Life Science

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Indirect calorimetry is the measurement of the amount of heat generated in an oxidation reaction by determining the intake or consumption of oxygen or by measuring the amount of carbon dioxide or nitrogen released and translating these quantities into a heat equivalent. In the last 20 years there has been significant development in both laboratory and computerized metabolic systems used in indirect calorimetry. In addition, there has been increased use of breath-by-breath EGAIC. Several researchers have suggested that breath-by-breath analysis, because of their practicality, could fulfill this need for a valid and reliable expired gas analysis indirect calorimetry instrument. It was hoped this investigation would determine the best validation for a precise measurement of breath-by-breath expired gas analysis indirect calorimetry. The problem with the available research is that few studies have examined the validity and reliability of all these different systems for breath-by-breath expired gas analysis indirect calorimetry. Therefore, there is a need to find out the most valid, reliable, and precise measurement of the breath-by-breath expired gas analysis indirect calorimetry.

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Indirect calorimetry: methodology, instruments and clinical application

Abstract: In conclusion, one has to be careful when choosing devices, and understanding and clinically applying the results obtained by indirect calorimetry, bearing in mind that measured resting energy expenditure should be the daily caloric goal in order to diminish clinical morbidity.

Cited by 145 publications

References 52 publications

Dissociated Oxygen Consumption and Carbon Dioxide Production in the Post–Cardiac Arrest Rat: A Novel Metabolic Phenotype

Dissociated Oxygen Consumption and Carbon Dioxide Production in the Post–Cardiac Arrest Rat: A Novel Metabolic Phenotype

Ghrelin and PYY3−36 in gastrectomized and vagotomized patients: relations with appetite, energy intake and resting energy expenditure

Historical Development of Nutrient and Calorimetry and Expired Gas Analysis Indirect Calorimetry

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