Individual nutrients and serum klotho levels in adults aged 40–79 years

Ostojić, Sergej M.; Hillesund, Elisabet Rudjord; Øverby, Nina Cecilie; Vik, Frøydis Nordgård; Medin, Anine Christine

doi:10.1002/fsn3.3310

Cited by 12 publications

(8 citation statements)

References 39 publications

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“…However, in the FIT-AGEING study (n = 72) [ 21 ], De-la-O et al found a negative correlation between carbohydrate intake and serum Klotho levels in females, but this correlation disappeared after controlling for covariates such as age, lean body mass index, and sedentary time. In contrast, Ostojic et al [ 19 ] reported a positive association between higher carbohydrate intake and soluble Klotho levels after adjusting for age and gender (n = 2637). Overall, these studies suggest that no consensus has been reached on the relationship between carbohydrate intake and Klotho levels.…”

Section: Discussionmentioning

confidence: 91%

“…However, a comprehensive link between carbohydrate intake levels and serum Klotho remains relatively unexplored in the existing literature. While an epidemiological study has suggested a synchronous increase between carbohydrate intake and soluble Klotho levels in the population [ 19 ], experimental research has further supported this finding [ 20 ]. Some experimental studies have indicated that a high-sucrose diet can elevate Klotho levels in mice compared to control mice.…”

Section: Introductionmentioning

confidence: 99%

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Inverse J-Shaped Relationship of Dietary Carbohydrate Intake with Serum Klotho in NHANES 2007–2016

Xiang,

Wu,

Wang

et al. 2023

Nutrients

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Background: The relationship between dietary carbohydrate intake and serum Klotho levels, an aging biomarker, remains uncertain. Objective: This study aimed to investigate the association between dietary carbohydrate intake and serum Klotho levels among American adults aged 40–79. Methods: We analyzed data from 10,669 adults aged 40–79 years who participated in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016. Trained interviewers assessed dietary carbohydrate intake using a 24 h dietary recall. Serum Klotho concentrations were measured using commercially available ELISA kits provided by IBL International, Japan, which served as the study outcome. Generalized linear models were used to assess the relationship between the carbohydrate energy percentage and serum Klotho concentration, and restricted cubic spline (RCS) analysis was employed to explore any nonlinear associations. Results: After adjusting for multiple variables, we observed a nonlinear inverse J-shaped relationship (p for non-linearity < 0.001) between the carbohydrate energy percentage and serum Klotho levels. Specifically, the highest serum Klotho levels were associated with a total carbohydrate energy percentage ranging from 48.92% to 56.20% (third quartile). When the carbohydrate energy percentage was evaluated in quartiles, serum Klotho levels decreased by 5.37% (95% CI: −7.43%, −3.26%), 2.70% (95% CI: −4.51%, −0.86%), and 2.76% (95% CI: −4.86%, −0.62%) in the first quartile (<41.46%), second quartile (41.46% to 48.92%), and fourth quartile (≥56.20%), respectively, compared to the third quartile. This relationship was more pronounced in male, non-obese and non-diabetic participants under 60 years of age. Conclusion: A non-linear inverse J-shaped relationship exists among the general U.S. middle-aged and older population between the carbohydrate energy percentage and serum Klotho levels, with the highest levels observed at 48.92% to 56.20% carbohydrate intake.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Inverse J-Shaped Relationship of Dietary Carbohydrate Intake with Serum Klotho in NHANES 2007–2016

Xiang,

Wu,

Wang

et al. 2023

Nutrients

View full text Add to dashboard Cite

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“…The National Health and Nutrition Examination Survey (NHANES) is a serial cross‐sectional survey that collects data on the nutritional and health status of the noninstitutionalized US population (Ostojic et al., 2023 ; Sun et al., 2023 ). This nationwide survey provides data through questionnaires, physical examinations, and laboratory tests (Ahluwalia et al., 2016 ; Shen et al., 2023 ).…”

Section: Methodsmentioning

confidence: 99%

Association between energy‐adjusted dietary inflammatory index and total immunoglobulin E: A cross‐sectional study

Su,

Wang,

Qin

et al. 2023

Food Science & Nutrition

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The relationship between a pro‐inflammatory diet, assessed by the dietary inflammatory index (DII), and allergic diseases has attracted attention. However, the association between DII and immunoglobulin E (IgE) remains uncertain. We aim to investigate the association between energy‐adjusted DII (E‐DII) and total IgE. We analyzed data from the 2005 to 2006 National Health and Nutrition Examination Survey. The relationship between E‐DII and total IgE was assessed using linear regression and logistic regression analysis. Meanwhile, we conducted a subgroup analysis stratified by body mass index (BMI) and analyzed the mediating role of BMI. We included 3614 adult participants. After controlling for confounding factors, there was no statistical association between E‐DII and total IgE (β 0.023, 95% CI −0.01 to 0.057, p = .173) and the risk of high total IgE (OR 1.036, 95% CI 0.977 to 1.099, p = .233). We conducted subgroup analysis stratified by BMI. After controlling for confounding factors, only in overweight groups, E‐DII was statistically associated with total IgE (β 0.076, 95% CI 0.017 to 0.135, p = .012) and the risk of high total IgE (OR 1.124, 95% CI 1.015 to 1.246, p = .025). Generalized additive models and smooth curve fittings showed a positive linear relationship between E‐DII and total IgE in overweight participants. No statistical association was noted for the mediation effect of BMI on the association between E‐DII and total IgE in the overweight group (p = .23). Overweight participants with higher E‐DII were potentially at risk of elevated total IgE.

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“…However, Klotho level happens to be influenced by the inflammatory and oxidative stress status of the body [ 28 , 35 ]. It has been reported that there is an association between dietary fiber intake and serum Klotho levels [ 36 ]. However, in-depth epidemiological studies of the relationship between these two based on large population samples are sorely lacking, and they deserve further exploration.…”

Section: Introductionmentioning

confidence: 99%

The Association between Dietary Fiber Intake and Serum Klotho Levels in Americans: A Cross-Sectional Study from the National Health and Nutrition Examination Survey

Liu

Wang

et al. 2023

Nutrients

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Background: Klotho is an aging-related marker closely associated with a number of diseases. A growing body of evidence suggests that dietary factors and lifestyle habits can impact serum Klotho levels. The effect of dietary fiber, a key component of a healthy diet, on the body’s serum Klotho levels has not been fully elucidated. Objective: The aim of this study was to explore the relationship between dietary fiber intake and serum Klotho levels in people aged 40–79 years in the United States. Methods: A total of 11,282 participants were included in this study, all from the National Health and Nutrition Examination Survey from 2007 to 2016. Dietary fiber intake was assessed by uniformly trained interviewers using the 24 h dietary recall method. Serum Klotho was quantified using commercially available ELISA kits manufactured by IBL International, Japan. The relationship between dietary fiber intake and serum Klotho levels was analyzed using a multiple linear regression model. Subsequently, the non-linear dose–response relationship between the two was further explored using a restricted cubic spline (RCS) model. Results: After adjusting for potential confounders, serum Klotho levels increased by 1.9% (95% confidence interval [CI]: 0.8%, 3.0%) for each interquartile range increase in dietary fiber intake in all participants. Considering dietary fiber intake as a categorical variable, serum Klotho levels were found to be 4.7% higher in participants in the highest quartile of dietary fiber intake than in those in the lowest quartile (95% CI: 1.8%, 7.6%). RCS plots depicted a non-linear positive correlation between dietary fiber intake and serum Klotho levels. Subgroup analysis revealed that the relationship between dietary fiber intake and serum Klotho levels was more pronounced in older (percentage change: 7.0%; 95% CI: 2.5%, 11.7%) and overweight and obese participants (percentage change: 4.9%; 95% CI: 1.5%, 8.4%). Conclusions: The results of this study showed that dietary fiber intake was significantly associated with serum Klotho levels in participants. This finding is yet to be further confirmed by prospective studies.

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Individual nutrients and serum klotho levels in adults aged 40–79 years

Cited by 12 publications

References 39 publications

Inverse J-Shaped Relationship of Dietary Carbohydrate Intake with Serum Klotho in NHANES 2007–2016

Inverse J-Shaped Relationship of Dietary Carbohydrate Intake with Serum Klotho in NHANES 2007–2016

Association between energy‐adjusted dietary inflammatory index and total immunoglobulin E: A cross‐sectional study

The Association between Dietary Fiber Intake and Serum Klotho Levels in Americans: A Cross-Sectional Study from the National Health and Nutrition Examination Survey

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