Individual quality of life of patients undergoing autologous peripheral blood stem cell transplantation

Frick, Eckhard; Borasio, Gian Domenico; Zehentner, H.; Fischer, N.; Bumeder, Irmgard

doi:10.1002/pon.730

Cited by 48 publications

(74 citation statements)

References 29 publications

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“…A total of 79 patients in the Frick et al study completed EORTC QLQ C-30 and estimated their role function before auto-SCT to be 43.16 compared with 45 in our study. 23 Almost the same result was found by the Nordic Myeloma Group studying autologous transplant patients 24 and Hjermstad and colleagues 22 who studied HRQL and fatigue 3 years or more after transplantation. Both MM and lymphoma patients in our study had a negatively influenced QoL at baseline, indicating that both groups had been affected by their disease and treatment history, which probably had consequences for the ability to live their lives as they did before they were ill. Week 2 was the period during which patients felt the most affected in terms of overall quality of life, functional status and symptom burden.…”

Section: Discussionsupporting

confidence: 61%

A prospective evaluation of patients' health-related quality of life during auto-SCT: a 3-year follow-up

Frödin

Börjeson

Lyth

et al. 2010

Bone Marrow Transplant

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Few studies have evaluated long-term health-related quality of life (HRQL) in patients during auto-SCT. This prospective study examined HRQL in 96 eligible patients before, during and up to 3 years after auto-SCT. The aim of the study was to make a comprehensive assessment of the frequency and severity of different symptoms in patients undergoing auto-SCT. The European Organization for Treatment and Research of Cancer Quality of Life Questionnaire (EORTC QLQ C-30) was administered 13 times. The second week during treatment was the period when patients had the lowest HRQL regarding both total quality of life and function and symptom scales. The patients recovered quickly and just two months after transplantation the baseline values were restored. Three years after transplantation most of the items in the questionnaire had stabilized, except role function and dyspnea, which had improved. There were significant differences between multiple myeloma (MM) and lymphoma patients' physical function, quality of life, fatigue and pain during week 2. At the 3-year follow-up, lymphoma patients indicated a better HRQL than MM patients. The quick recovery of patients after transplantation suggests that treatment is well tolerated; however, the supportive care could be improved at week 2, especially for the lymphoma patients.

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Section: Discussionsupporting

confidence: 61%

A prospective evaluation of patients' health-related quality of life during auto-SCT: a 3-year follow-up

Frödin

Börjeson

Lyth

et al. 2010

Bone Marrow Transplant

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“…4,8 Many studies have also used heterogenous groupings of cancer patients. 20,21 All of the patients in this study had stage III breast cancer under the new classification system. They all also received the same chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

A longitudinal prospective study of health-related quality of life in breast cancer patients following high-dose chemotherapy with autologous blood stem cell transplantation

Cumming²,

et al. 2005

Bone Marrow Transplant

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Summary:This prospective longitudinal study examined both shortand long-term changes in health-related quality of life (HRQL) in 52 breast cancer patients with poor prognosis receiving high-dose chemotherapy (HDC) treatment with autologous blood stem cell transplantation (ASCT). HRQL was measured seven times from baseline to 2 years post enrollment with the Functional Living IndexCancer (FLIC), the EuroQol (EQ-5D), and a quality of life visual analogue scale. The percentage of questionnaires returned at each assessment time ranged from 80 to 92%. All three measures showed a similar pattern of change, with HRQL decreasing following administration of HDC, and returning to baseline levels 8 weeks post HDC. A repeated-measures analysis of variance showed that the FLIC at 2 years was significantly better than baseline (P ¼ o0.0001). Difficulty sleeping, headaches, and decreased sexual interest were the most common symptoms reported in the longer term. Our results have implications for early psychosocial intervention in the care of breast cancer patients with poor prognosis undergoing treatment with HDC and ASCT because such interventions can further improve the quality of their survival.

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“…Finally, the problem of adequacy of the used HRQoL scale [49] and possible response shifts (recalibrations of internal standards of reference used by the respondent [17,54] merit asking whether the used instruments were sufficiently sensitive for evaluating a psychotherapeutic intervention, and whether we chose the appropriate outcomes (HRQoL/ emotional distress). An alternative would have been a specific disorder diagnosis, goal setting and evaluation, e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The remainder of those HRQoL dimensions still impaired may correspond to postponed, unrecognised [23], denied or repressed [2,27,37] concerns which can nevertheless jeopardise the survivors' course of recovery. These tenacious QoL-related concerns should be addressed as soon as possible and individually, i.e., according to the patients' subjective priorities and value-system [17]. Improvement of QoL using psychotherapy is helpful for patients undergoing HCT, especially in better symptom control [47], in the improvement of patients' compliance [41], in fostering aerobic exercise [14], and in encouraging helpful social support.…”

Section: Introductionmentioning

confidence: 99%

When is the best time for psychotherapeutic intervention following autologous peripheral blood stem cell transplantation?

Frick¹,

Tyroller²,

Fischer³

et al. 2006

Rev Francoph Psycho Oncologie

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Acknowledgements:The authors would like to thank Ross Allan Lazar who supervised our psychotherapeutic work and the Deutsche José Carreras Leukämie-Stiftung that in part funded this study (Grant Number DJCLS-R02/21p).Abstract: Background and objective: To compare the impact of (A) an earlier (months 1 to 6 after PBSCT) vs. (B) a later (months 6 to 12) individualised psychodynamic short-time psychotherapy on health related quality of life.

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Individual quality of life of patients undergoing autologous peripheral blood stem cell transplantation

Cited by 48 publications

References 29 publications

A prospective evaluation of patients' health-related quality of life during auto-SCT: a 3-year follow-up

A prospective evaluation of patients' health-related quality of life during auto-SCT: a 3-year follow-up

A longitudinal prospective study of health-related quality of life in breast cancer patients following high-dose chemotherapy with autologous blood stem cell transplantation

When is the best time for psychotherapeutic intervention following autologous peripheral blood stem cell transplantation?

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