The splint therapy is the most common and recommendable standard therapy for craniofacial pain. This type of therapy can obtain muscle relaxation and improvement of neuromuscular coordination. The aim of the article is to exemplify the clinical course of the dental diagnostics and splint therapy of patients with craniofacial pain. Summary: A patient with craniofacial pain was treated using splint therapy. The therapeutic approach consisted in eliminating centric and eccentric occlusal disturbances, rebuilding lost support zones, and changing the mandibular motion pattern in order to improve muscle tone and neuromuscular coordination. Successful implementation required that, in centric relation and therefore in the splint position, the condyle-disc unit should be still largely intact and the interarticular space not constricted. As a result of the splint treatment, the patient was free of headaches, TMJ problems, and tinnitus, despite continuing work in a very intensive and responsible occupation. Recently, the patient reported not needing the splint at all during a sailing holiday in the Mediterranean. Key learning points: This special type of splint therapy should be conducted in association with muscle massages and physiotherapy exercises, because the jaw relations must adapt to the premature contacts which arise on the splint at first.