Individual variability of high-sensitivity cardiac troponin levels after aerobic exercise is not mediated by exercise mode

Abstract

Individual variability of high-sensitivity cardiac troponin levels after aerobic exercise is not mediated by exercise mode http://researchonline.ljmu.ac.uk/3170/ Article LJMU has developed LJMU Research Online for users to access the research output of the University more effectively. Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Users may download and/or print one copy of any article(s) in LJMU Research Online to facilitate their private study or for non-commercial research. You may not engage in further distribution of the material or use it for any profit-making activities or any commercial gain.The version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription. AbstractWe compared the response of high-sensitivity cardiac troponin T (hs-cTnT) after 60 min of swimming, running, and cycling in well trained triathletes. The maximal increase in hs-cTnT was similar in all exercise bouts (swimming 453%, cycling 349% and running 471%) although there was substantial individual variability in peak hs-cTnT. The post-exercise kinetics for hs-cTnT were consistent. The change in hs-cTnT was correlated between trials. In all trials hs-cTnT had largely returned to baseline levels 24 h post-exercise. In summary, an increase in hs-cTnT was apparent in all triathletes independent of exercise mode and despite variable peak data the consistent kinetics over 24 h post-exercise would suggest this represents a physiological phenomenon.

Cardiac Biomarker Release after Endurance Exercise in Male and Female Adults and Adolescents

“…This study confirms that the exercise-induced release of cTn and NT-proBNP is not exclusive to an ultra-endurance effort in adult athletes. 5,6,23,24 There is some evidence to suggest that cTn release during prolonged exercise is positively associated with exercise intensity. 25,26 Thus, the high intensity shown by our swimmers could explain the release of hs-cTnT.…”

The impact of high‐intensity interval training on the cTnT response to acute exercise in sedentary obese young women

“…Further determination of factors mediating this heterogeneity was constrained by our relatively small and homogeneous cohort. Of note, addressing a principal limitation of other studies 16,32,33,35 that typically focused on single factors, Eijsvogels et al assessed the influence of multiple parameters on post-exercise cTnI levels in a large and heterogeneous cohort and noted a large portion (>90%) of the post-exercise cTnI levels cannot be explained. 36 Therefore, one may suggest that cTn increases seem to be random and be irrespective of subject and exercise characteristics.…”

High-sensitivity cardiac troponin T in young, healthy adults undergoing non-cardiac surgery

“…An interesting observation into the nature of hscTn elevations stems from cardiac biomarker studies in young, healthy adults during exercise, where a substantial number of athletes develop significant post-exercise hscTn elevation >300%. 8,22 The origin is not well understood, but some data suggest that the aetiology for such elevations is the right ventricle. 23,24 Typically, hscTn elevations after myocardial injury are more sustained (>12 h), whereas exercise-induced hscTn elevation in athletes without cardiac symptoms can be short lived (<12 h), 25 although studies are lacking that measure the duration until hscTn values return to baseline.…”

“…For example, a recent study in healthy triathletes found a >300% increase of cTn concentrations after 1 h of high-intensity exercise. 8 A study involving healthy volunteers showed that a brief dobutamine infusion causes an increase in high-sensitivity cardiac troponin T (hscTnT). 9 Likewise, rapid atrial pacing leads to a significant increase in hscTnT, both in patients with or without significant coronary-artery disease.…”