Indo-Asian experience of renal transplantation in Yorkshire

Jeffrey, Robin F.; Woodrow, Graham; Mahler, Joanna; Rj, Johnson; Newstead, Charles G.

doi:10.1097/00007890-200205270-00022

Cited by 39 publications

(28 citation statements)

References 14 publications

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“…Higgins et al reported a nonactuarial graft survival of 73% and 72% at 3 years for South Asian and European patients, respectively, in Coventry and Warwickshire (16). In a recent article, however, Jeffrey et al suggested that South Asians suffer higher death rates with functioning grafts, and as a consequence they enjoy a lower transplant survival (58% at 5 years compared with 71% for non-Asians) (9). Death with a functioning graft at 5 years affected 11% of the non-Asians and 22% of the South Asians (PϽ0.03) in their cohort.…”

Section: Discussionmentioning

confidence: 96%

“…In transplantation, the experience of South Asians in the United Kingdom is often compared with that of African Americans in the United States, in that both groups suffer low rates of transplantation and have been reported to have poorer outcomes than their white counterparts (8,9). Jeffrey et al analyzed the outcomes of 608 transplant patients (52 South Asians) who underwent transplantation between 1985 and 1994.…”

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confidence: 99%

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Outcome of Renal Transplantation in South Asian Recipients is Similar to that in Non-Asians

et al. 2004

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Section: Discussionmentioning

confidence: 96%

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confidence: 99%

Outcome of Renal Transplantation in South Asian Recipients is Similar to that in Non-Asians

et al. 2004

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“…Three small UK studies appear to draw contradictory conclusions. Jeffrey et al, comparing the graft outcomes of 52 Indo-Asian transplant recipients with those of 556 non-Indo-Asians, reported a trend toward lower 5-year graft survival and a higher incidence of death with a functioning graft (6). However, Loucaidou et al, comparing 53 Indo-Asian transplant recipients with 192 non-Indo-Asians, (7) and Higgins et al, comparing 19 Indo-Asian transplant recipients with 157 non-Indo-Asians, (8) both found no differences in outcome, although even Loucaidou et al noted a tendency to worse 3-5 year survival in Indo-Asians, (which was not statistically significant).…”

Section: Introductionmentioning

confidence: 99%

Renal Transplantation in Indo-Asian Patients in the UK

Dooldeniya

Dupont

et al. 2006

American Journal of Transplantation

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Membership of some ethnic groups has an effect on renal transplant outcome but little is known about the impact of Indo-Asian ethnicity, despite this group's high incidence of renal disease. We compared outcomes in Indo-Asians and Caucasians at the Hammersmith Hospital (Indo-Asians, N = 46; Caucasians, N = 90), in the Long-Term Efficacy and Safety Surveillance (LOTESS) database of cyclosporin-treated renal transplant recipients (Indo-Asians, N = 254; Caucasians, N = 4262) and the National Transplant Database held by UK Transplant (Indo-Asians, N = 459; Caucasians, N = 4831). The baseline demographic and co-morbid characteristics of the two ethnic groups were comparable, save for more diabetes in the Indo-Asian community. Following transplantation, the incidence of delayed graft function and steroid-resistant acute rejection were also comparable, as were graft and patient survival (out to 5 years) and graft function. In addition, post-transplant blood pressure, levels of cholesterol and triglycerides and exposure to corticosteroids and cyclosporin were comparable. However, when patients who were not diabetic before transplantation were studied separately, there was an increased incidence of diabetes in the Indo-Asian community (Hammersmith data: Indo-Asians 10.9% vs. Caucasians 3.3%, p = 0.02; LOTESS data Indo-Asians 5.5% vs. Caucasians 1.6%, p < 0.0001). Subsequent management of this group should pursue immunosuppressive regimens less likely to impair post-transplant glucose tolerance.

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“…This means that unless the Asian community donates organs in proportion to its need the waiting list situation will deteriorate even further (Ready 1988). But to date the UK South Asian community has an especially low rate of organ donation from deceased donors (DH 2008b;Jeffrey et al 2002). The South Asian population constitutes 4% of the UK population (ONS 2003), but over the last 6 years on average only 1.5% of those joining the Organ Donor Register and only 1.3% of deceased organ donors are South Asian (NHSBT 2008).…”

Section: Introductionmentioning

confidence: 99%

Whose Decision is it? Organ Donation Attitudes Among Young UK South Asians

Joshi

2011

Psychol Stud

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A questionnaire study examined organ donor card holding rates and attitudes to organ donation among young adult British South Asians and Whites attending institutions of higher education in the UK. There were 382 respondents (166 male, 216 female, average age 21.8 years): 107 Indian (Hindu or Sikh), 104 Pakistani/Bangladeshi (Muslim) and 171 White (Christian or of no religion). Overall, 33% of White but only 9% of South Asian respondents had a donor card. Among Whites, only 6% thought their parents would find it emotionally very upsetting to discuss organ donation, and of the White card holders 70% had told their parents that they had a card. In contrast 18% of Indians and 52% of Pakistanis/Bangladeshis thought that their parents would find it emotionally very upsetting to discuss organ donation, and only 39% of South Asian card holders had told their parents that they had a card. Finally, 41% of White, 54% of Indian and 91% of Pakistanis/ Bangladeshi respondents doubted that they would take steps to obtain an organ donor card. White respondents proffered inertia as the main explanation for their not being likely to get a card. The factors underlying South Asian respondents not planning to obtain a card were more varied and included disinterest, emotional distaste, family opposition and religion. These reasons can be interpreted as relating to an interdependent conception of self and donor decisions being a family as well as an individual matter.

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Indo-Asian experience of renal transplantation in Yorkshire

Cited by 39 publications

References 14 publications

Outcome of Renal Transplantation in South Asian Recipients is Similar to that in Non-Asians

Outcome of Renal Transplantation in South Asian Recipients is Similar to that in Non-Asians

Renal Transplantation in Indo-Asian Patients in the UK

Whose Decision is it? Organ Donation Attitudes Among Young UK South Asians

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