Indocyanine green angiography: A new method to quantify collateral flow in mice

Wuestenfeld, Jan C.; Herold, Joerg; Niese, Ulrike; Kappert, Utz; Schmeißer, Alexander; Strasser, Ruth H.; Braun-Dullaeus, Ruediger C.

doi:10.1016/j.jvs.2008.06.049

Cited by 17 publications

(18 citation statements)

References 25 publications

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“…Wuestenfeld et al evaluated the applicability of the ICG angiography for the determination of hind limb perfusion in mice and compared it to LDPI. The authors suggest that ICGA is a potent tool for the quantification of collateral flow in small animal models and that LDPI shows unreliable high perfusion in the operated foot after one week indicating that it measures perfusion in the superficial skin rather than entire hind limb [145]. …”

Section: Surgical Applicationsmentioning

confidence: 99%

A Review of Indocyanine Green Fluorescent Imaging in Surgery

Alander

Kaartinen

Laakso

et al. 2012

International Journal of Biomedical Imaging

1,105

876

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Section: Surgical Applicationsmentioning

confidence: 99%

A Review of Indocyanine Green Fluorescent Imaging in Surgery

Alander

Kaartinen

Laakso

et al. 2012

International Journal of Biomedical Imaging

1,105

876

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“…Repetitive measures are important for diagnostics and for monitoring therapeutic efficacy. Such techniques have been developed in other organs, the brain, and in tumors and include non-invasive in vivo blood flow measurements using ultrasound, laser Doppler, laser speckle imaging, near infrared spectroscopy, micro-CT, PET scanning with EC-selective ligands, MRI), real-time multi-photon microscopy, optical frequency domain imaging, and luminosity measurements with fluorescent probes [19,51,93,97,155,156,167,182]. Few groups have access to such equipment and fewer have applied this to spinal cord injury [13,23,24,30,33,39,67,73,126,146,151].…”

Section: Ec Biomarkers Of Microvascular Survival and Function Followimentioning

confidence: 99%

Vascular Pathology as a Potential Therapeutic Target in SCI

Benton

Hagg

2011

Transl. Stroke Res.

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Acute traumatic spinal cord injury (SCI) is characterized by a progressive secondary degeneration which exacerbates the loss of penumbral tissue and neurological function. Here, we first provide an overview of the known pathophysiological mechanisms involving injured microvasculature and molecular regulators that contribute to the loss and dysfunction of existing and new blood vessels. We also highlight the differences between traumatic and ischemic injuries which may yield clues as to the more devastating nature of traumatic injuries, possibly involving toxicity associated with hemorrhage. We also discuss known species differences with implications for choosing models, their relevance and utility to translate new treatments towards the clinic. Throughout this review, we highlight the potential opportunities and proof-of-concept experimental studies for targeting therapies to endothelial cell-specific responses. Lastly, we comment on the need for vascular mechanisms to be included in drug development and non-invasive diagnostics such as serum and cerebrospinal fluid biomarkers and imaging of spinal cord pathology.

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“…To account for the distinct and unique features of collateral artery growth, the term arteriogenesis was introduced [5,6]. In order to investigate underlying physiological and biochemical processes and the influence of endogenous and exogenous factors on vascular growth, several in vivo models were developed [2,[7][8][9][10]. One of the models most commonly used to examine vascular growth is the hind limb model.…”

Section: Introductionmentioning

confidence: 99%