Indocyanine green angiography findings in patients with neovascular age-related macular degeneration refractory to ranibizumab switched to aflibercept

Calvo-González, C; Reche-Frutos, J; Fernández‐Vigo, José Ignacio; Donate-López, J.; Serrano-García, Irene; Fernández-Pérez, Cristina

doi:10.1007/s10792-019-01082-z

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…Thus, an extensive imaging workup may be required. In case of polypoidal lesions which are best identified on indocyanine green angiography [11], an adjuvant treatment with photodynamic therapy might be a good option [12]. In addition, the inflammatory pathways have been shown to be involved in nAMD [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Refractory neovascular age-related macular degeneration: time-dependent changes of central retinal thickness with anti-VEGF treatment

Zola

D’Alessandro

Sherif

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Purpose To assess the influence of time interval since last injection and time from baseline on central retinal thickness (CRT) in neovascular age-related macular degeneration (nAMD) with fluid refractory to monthly anti-VEGF treatment. Methods This retrospective study included nAMD eyes with incomplete response to anti-VEGF defined by the presence of intra- or subretinal fluid on optical coherence tomography despite maximal (monthly) anti-VEGF dosing. The outcome measure was CRT, and two time variables (time from last injection ant time from baseline) were the independent factors included in the individual correlation analyses. In addition, an association analysis was performed. Results Sixty eyes of 56 patients (67.9% females, mean age: 78.7 ± 6.8 years) were included with a mean included time period of 35.6 months. A significant positive correlation between CRT and the time from last injection occurred in 24 (40%) and 25 (42%) eyes by univariate and multivariate analysis, respectively. Time from baseline was significantly correlated with CRT in 29 (48.3%) and 30 (50%) eyes by univariate and multivariate analysis, respectively. This correlation was positive in 12 (20%) and negative in 18 eyes (30%). No association with such correlation was found. Conclusion So-called refractory nAMD frequently shows a correlation of CRT with the interval in days from the preceding anti-VEGF injection, revealing that there is a subgroup of short-term responsiveness of the residual fluid. Moreover, slower CRT changes may occur over the years, either decrease or increase. In case of a slow CRT increase, this might require a diagnostic workup and therapeutic change.

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