2012
DOI: 10.1117/1.jbo.17.11.116025
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Indocyanine-green-loaded microballoons for biliary imaging in cholecystectomy

Abstract: Abstract. We encapsulate indocyanine green (ICG) in poly[(D,L-lactide-co-glycolide)-co-PEG] diblock (PLGA-PEG) microballoons for real-time fluorescence and hyperspectral imaging of biliary anatomy. ICG-loaded microballoons show superior fluorescence characteristics and slower degradation in comparison with pure ICG. The use of ICG-loaded microballoons in biliary imaging is demonstrated in both biliary-simulating phantoms and an ex vivo tissue model. The biliary-simulating phantoms are prepared by embedding ICG… Show more

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Cited by 27 publications
(19 citation statements)
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“…MHSI has the capacity of real-time imaging, which enables the surgeon to make or confirm diagnosis and evaluate surgical therapy in an ongoing fashion in the operation room. 189 Overall, MHSI has been explored in surgeries, such as mastectomy, 45 gall bladder surgery, 192 cholecystectomy, 54,133 nephrectomy, 193,194 renal surgery, 80,191,193,195,196 abdominal surgery, 95 and intestinal surgery. 91 The following section will introduce these researches in details.…”
Section: Surgical Guidancementioning
confidence: 99%
“…MHSI has the capacity of real-time imaging, which enables the surgeon to make or confirm diagnosis and evaluate surgical therapy in an ongoing fashion in the operation room. 189 Overall, MHSI has been explored in surgeries, such as mastectomy, 45 gall bladder surgery, 192 cholecystectomy, 54,133 nephrectomy, 193,194 renal surgery, 80,191,193,195,196 abdominal surgery, 95 and intestinal surgery. 91 The following section will introduce these researches in details.…”
Section: Surgical Guidancementioning
confidence: 99%
“…29,41 1) 25 mg/mL PLGA solution in methylene chloride and 2 mg/mL ICG solution in water were prepared in advance and PVA was dissolved in water to form 5% w/v aqueous solution. 2) 200 µL PFP was bubbled with oxygen gas till saturation and added to ICG aqueous solution and the mixture was subjected to vibration for 1 min using an ultrasonic probe (Sonics & Materials, Inc., Fairfield, CT, USA).…”
Section: Preparation Of Oi-npsmentioning
confidence: 99%
“…The system is not suitable for surgical guidance in thick tissue or tissue of high absorbance, such as liver tumor resection. We have previously demonstrated that fluorescence emission of a simulated bile duct structure embedded 7 mm deep in a tissue simulating phantom can be imaged using ICG-loaded microballoons in combination with near infrared light (16). Further increase of the imaging depth for the wearable navigation system requires spatial guidance provided by other imaging modalities (23; 24).…”
Section: Discussionmentioning
confidence: 99%
“…In the past, optical imaging has been explored for surgical margin assessment in various medical conditions such as tumor delineation (57), lymph node mapping (8; 9), organ viability evaluation (10), tissue flap vascular perfusion assessment during plastic surgery (11), necrotic boundary identification during wound debridement (12; 13), breast tumor characterization (14), chronic wound imaging (15), and detection of iatrogenic bile duct injuries during cholecystectomy (16). However, these imaging systems are not wearable devices.…”
Section: Introductionmentioning
confidence: 99%