Indocyanine Green Lymphography for Evaluation of Breast Lymphedema Secondary to Breast Cancer Treatments

Yamamoto, Takumi; Yamamoto, Naoki

doi:10.1055/s-0042-1742732

Cited by 14 publications

(11 citation statements)

References 42 publications

(217 reference statements)

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“…Takumi et al successfully obtained clear images of the superficial lymph circulation of the breast using Indocyanine Green lymphography. According to their previous Indocyanine Green lymphography staging of breast lymphedema, higher staging could be related to higher incidence of symptoms related to breast lymphedema 21 . Nevertheless, a review by Sato and Yamamoto described that postoperative lymphedema is not a significant prognostic factor for patients with secondary breast angiosarcoma 22 .…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

Wang

et al. 2023

Cancer Medicine

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Background: Angiosarcoma of the breast is a rare malignancy. There are little data evaluating the survival and estimating the prognostic factors. The best surgical management and the role of systemic adjuvant therapy remain ill-defined.This study aimed to investigate the clinicopathological features, survival, and prognostic factors of breast angiosarcoma. Methods:The data on patients diagnosed with breast angiosarcoma were extracted from the Surveillance, Epidemiology, and End Results database . Univariate and multivariate Cox regression analyses were used to estimate the influential prognostic factors. The overall survival (OS) and disease-specific survival (DSS) of patients with breast angiosarcoma were evaluated.Results: This study included 656 patients diagnosed with breast angiosarcoma between 1975 and 2016. The 5-year OS rate of all patients was 44.9% (95% CI 40.8-49.0). In both OS and DSS, Kaplan-Meier survival analyses revealed significant differences for both OS and DSS according to age, year at diagnosis, laterality, grade, and stage (all log-rank p < 0.05). Multivariate analysis suggested that lesions of the right breast, poor differentiation, and advanced stage were independent risk factors for OS or DSS (all p < 0.05). Older age was a risk factor in OS, but was protective in DSS. In primary breast angiosarcoma, age, laterality, grade, and stage were independent prognostic factors in OS and DSS (all p < 0.05).Mastectomy was also a risk factor in DSS (p = 0.034). The proportion of patients with grade III and regional disease was larger in the mastectomy group. Conclusion:Angiosarcoma of the breast had a poor prognosis. In our study, age, laterality, histologic grade, and stage were identified as significant prognostic factors. Why patients with angiosarcoma of the right breast had a worse prognosis remains equivocal. Mastectomy was adopted more often by surgeons in this cohort study for patients with advanced primary breast angiosarcoma.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

Wang

et al. 2023

Cancer Medicine

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“…It is evident from previous cases that STS has a worse prognosis than other skin malignancies, and early diagnosis and treatment are imperative; however, STS is insidious, and many diagnoses rely on subjective assessment [ 24 , 25 ]. In recent years, studies have been performed using TDC and indocyanine green (ICG) lymphography to objectively assess the status of lymph node circulation, providing new ideas for early diagnosis of the disease [ 26 , 27 ]. Unfortunately, information on lymph node edema is not available in the SEER database.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis and prognostic treatment study of angiosarcoma of the breast: a SEER population-based analysis

Yan

Yang

et al. 2023

World J Surg Onc

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Introduction Breast angiosarcoma is a rare malignancy of endovascular origin, accounting for less than 1% of all mammary cancers. Our aim was to explore clinicopathological features and the factors associated with prognosis. Methods We extracted information from the Surveillance, Epidemiology, and End Results Program (SEER) for all patients with breast angiosarcoma between 2004 and 2015. Chi-square analysis was used to compare the clinicopathological features in all patients. Overall survival (OS) was assessed using the Kaplan and Meier method. Univariate and multivariate analyses were performed to evaluate the factors associated with prognosis. Results A total of 247 patients were included in the analyses. The median OS of patients with primary breast angiosarcoma (PBSA) and secondary breast angiosarcoma (SBAB) was 38 months and 42 months, respectively. The 1-, 3- and 5-year OS with PBSA was 80%, 39%, and 25%, respectively, and the 1-, 3- and 5-year OS with SBAB was 80%, 42%, and 34%, respectively. Multivariate analysis revealed that tumor size (p = 0.001), tumor grade (p < 0.001), tumor extension (p = 0.015), and tumor spread (p < 0.001) were statistically significant factors for OS. Partial mastectomy with radiation (HR = 0.160, 95% CI, 0.036–0.719, p = 0.016), partial mastectomy with chemotherapy (HR = 0.105, 95% CI, 0.011–1.015, p = 0.052), and partial mastectomy (HR = 0.125, 95% CI, 0.028–0.583, p = 0.007) were related to significantly better OS outcomes in primary angiosarcoma. Conclusion Primary breast angiosarcoma has a better clinical phenotype than secondary breast angiosarcoma. Although overall survival was not statistically significant, primary breast angiosarcoma was better than secondary breast angiosarcoma with systemic therapy. Depending on the outcome of survival, partial mastectomy is effective in treating primary breast angiosarcoma.

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“…Skin changes secondary to radiation were also noted throughout the right breast. helps to offload venous congestion and reduce venous hypertension (Yamamoto & Yamamoto, 2022). Excellent perfusion to the flap was noted.…”

Section: Case Reportmentioning

confidence: 93%

“…Given significant venous flow through the left gastroepiploic vein, an intra‐flap arteriovenous fistula was created between the left gastroepiploic artery and vein utilizing a 1.5 mm coupler. The arteriovenous fistula helps to offload venous congestion and reduce venous hypertension (Yamamoto & Yamamoto, 2022). Excellent perfusion to the flap was noted.…”

Section: Case Reportmentioning

confidence: 99%

Omental vascularized lymph node transplant for the treatment of breast lymphedema: A case report

et al. 2023

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Breast lymphedema is a type of breast cancer related lymphedema that leads to significant discomfort and negative impact on body image. Conservative therapy and lymphovenous bypass have been previously described as possible treatment methods for breast lymphedema, however, a unified approach to treatment is lacking. The current report describes a case of breast lymphedema successfully treated with vascularized lymph node transfer (VLNT) after failed attempt at management with conservative therapy. The patient is a 48-year-old female with right-sided breast cancer who underwent breast conservation therapy in 2015 and subsequently developed pain and swelling of the right breast. The diagnosis of breast lymphedema was supported by clinical evaluation as well as MRI, lymphoscintigraphy, and lymphography. In consultation with a breast surgeon, breast lymphedema was determined not to be an indication for mastectomy. The patient was offered and underwent an omental VLNT to the right breast. A 20 cm segment of omentum with associated gastroepiploic vessels and lymph nodes was harvested, transferred to the right axilla and gastroepiploic vessels were anastomosed to the recipient thoracodorsal vessels.

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Indocyanine Green Lymphography for Evaluation of Breast Lymphedema Secondary to Breast Cancer Treatments

Cited by 14 publications

References 42 publications

Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

Clinicopathological characteristics and survival outcomes in patients with angiosarcoma of breast

Clinicopathological analysis and prognostic treatment study of angiosarcoma of the breast: a SEER population-based analysis

Omental vascularized lymph node transplant for the treatment of breast lymphedema: A case report

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