Indole Alkaloids and Other Constituents of Rauwolfia serpentina

Abstract

From the dried roots of Rauwolfia serpentina were isolated five new indole alkaloids, N(b)-methylajmaline (1), N(b)-methylisoajmaline (2), 3-hydroxysarpagine (3), yohimbinic acid (4), isorauhimbinic acid (5), a new iridoid glucoside, 7-epiloganin (6), and a new sucrose derivative, 6'-O-(3,4,5-trimethoxybenzoyl)glomeratose A (7), together with 20 known compounds. The structures of the new compounds were determined by spectroscopic and chemical means. The inhibitory activities of the selected alkaloids on topoisomerase I and II and their cytotoxicity against the human promyelocytic leukemia (HL-60) cell lines were assessed.

In vitro callus induction in inflorescence segments of medicinally important endangered plant Rauwolfia serpentina (L.) Benth. ex Kurz – a step towards ex situ conservation

“…(http://www.bsienvis.nic.in/CITES/R.%20serpenti na). The alkaloids of the species are anticarcinogenic (Stanford et al, 1986), treats human promyelocytic leukemia (Itoh et al, 2005), antihypertensive (Von Poser et al, 1990), treats cardiovascular diseases (Anitha and Kumari, 2006), arrhythmia (Kirillova et al, 2001), psychiatric diseases (Bhatara et al, 1997;Kirtikar and Basu, 1993) and anti-diabetic (Pathania et al, 2013).…”

Rauvotetraphyllines A-E, new indole alkaloids from Rauvolfia tetraphylla

“…The isolation and structure elucidation of three indole alkaloids rauvoyunines A, B, and C from the aerial parts of Rauvolfia yunnanensis have been reported earlier. 5 As one part of our ongoing research program exploring bioactive indole alkaloids from Chinese species of Rauvolfia, phytochemical analysis has been carried out on the aerial parts of R. tetraphylla collected from Yunnan Province, with particular attention to the monoterpene indole constituents, and has resulted in the isolation of five new alkaloids, rauvotetraphyllines A-E (1)(2)(3)(4)(5), as well as eight known analogues, alstonine (6), 6 nortetraphyllicine, 7 peraksine, 8 sarpagine, 9 3-hydroxysarpagine, 10 dihydroperaksine, 11 10-hydroxydihydroperaksine, 11 and raucaffricine. 12 The present paper reports the isolation, structure elucidation, and cytotoxic evaluation of the new compounds.…”

Integrated Text Mining and Chemoinformatics Analysis Associates Diet to Health Benefit at Molecular Level

“…Riboflavin monophosphate, for example, which is found in many common foods such as almond, broccoli and tomato, is one among the 16 phytochemicals we have identified with biological activity against thymidylate synthase, the main target of drugs 5-fluorouracil and capecitabine [33]. Similarly, reserpine, a natural compound that has found applications as antihypertensive and antipsychotic, exhibits activity against DNA topoisomerase I [34] - the target of the colon cancer drug irinotecan - which could be interesting to investigate further in the light of drug repurposing.…”