Indole Alkaloids from Marine Sources as Potential Leads against Infectious Diseases

França, Paulo Henrique Barcellos; Barbosa, Daniel P.; Silva, Daniel L. da; Ribeiro, Êurica Adélia Nogueira; Santana, Antônio Euzébio Goulart; Santos, Bárbara V. O.; Barbosa-Filho, José Maria; Quintans, Jullyana S. S.; Barreto, Rosana S.S.; Quintans‐Júnior, Lucindo J.; Araújo-Júnior, João Xavier de

doi:10.1155/2014/375423

Cited by 26 publications

(17 citation statements)

References 80 publications

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“…Interestingly, all three bioactive compounds identified in this study are all indole alkaloids. Indole forms the core chemical component of a number of biologically active natural product molecules [ 27 ]. The indole nucleus is considered a privileged structure as it is an important ring system often associated with pharmaceutical development.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Antibacterial Activity of Indole Alkaloids from Pseudomonas aeruginosa UWI-1

et al. 2020

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In this study, we report the first isolation of three antibiotic indole alkaloid compounds from a Pseudomonad bacterium, Pseudomonas aeruginosa UWI-1. The bacterium was batch fermented in a modified Luria Broth medium and compounds were solvent extracted and isolated by bioassay-guided fractionation. The three compounds were identified as (1) tris(1H-indol-3-yl) methylium, (2) bis(indol-3-yl) phenylmethane, and (3) indolo (2, 1b) quinazoline-6, 12 dione. A combination of 1D and 2D NMR, high-resolution mass spectrometry data and comparison from related data from the literature was used to determine the chemical structures of the compounds. Compounds 1–3 were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms using the broth microdilution technique. Compounds 1 and 2 displayed antibacterial activity against only Gram-positive pathogens, although 1 had significantly lower minimum inhibitory concentration (MIC) values than 2. Compound 3 displayed potent broad-spectrum antimicrobial activity against a range of Gram positive and negative bacteria. Several genes identified from the genome of P. aeruginosa UWI-1 were postulated to contribute to the biosynthesis of these compounds and we attempted to outline a possible route for bacterial synthesis. This study demonstrated the extended metabolic capability of Pseudomonas aeruginosa in synthesizing new chemotypes of bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

Isolation and Antibacterial Activity of Indole Alkaloids from Pseudomonas aeruginosa UWI-1

et al. 2020

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“…(c) Antiviral marine pharmacology: marine natural products with antiviral potential [330]; antiviral activity in marine fungi-derived natural products [331]. (d) Antiprotozoal and antimalarial marine pharmacology: antiprotozoal activity in marine natural products isolated from marine algae [332]; marine indole alkaloids as potential leads for antiprotozoal drugs [333]; antimalarial potency of the manzamine β-carboline alkaloids [334]. (e) Immuno-and anti-inflammatory marine pharmacology: marine diterpenoids as potential anti-inflammatory agents [335]; microalgae bioactive compounds for inflammation and cancer [336].…”

Section: Reviews On Marine Pharmacology and Pharmaceuticalsmentioning

confidence: 99%

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2019

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The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

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“…The structure of β-carboline is like tryptamine, with the ethylamine chain re-connected to the indole nucleus via an extra carbon atom to produce a three-ringed structure ( Dewick, 2002 ). Since its initial discovery in the year 1841, β-carboline alkaloids have been isolated from various sources, principally plants (mainly in Rutaceae, Simaroubaceae, Amaranthaceae, Caryophyllaceae, Rubiaceae and Zygophyllaceae ), marine creatures (hydroids, bryozoans, soft corals) and marine sponges ( França et al., 2014 ). They are also present in microorganisms, insects, food products ( Piechowska et al., 2019 ), alcoholic beverages, tobacco smoke, as well as human tissues and body fluids.…”

Section: Introduction To β-Carboline and Allied Structuresmentioning

confidence: 99%

Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives – An update

Kumar

Faheem

Chandrasekhar

et al. 2020

Heliyon

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Leishmaniasis is the most widespread pathogenic disease in several countries. Currently, no effective vaccines are available, and the control of Leishmaniasis primarily relies on decade-old chemotherapy. The treatment for the Leishmaniasis is not up to the mark. Current therapy for Leishmaniasis is ancient and requires hospitalization for the administration. These medications are also highly toxic and resistant. β-carboline, a natural indole containing alkaloid, holds a vital position in the field of medicinal chemistry with a diversified pharmacological action. The current review focuses mainly on the anti-leishmanial effects of β-carboline analogs and their synthetic strategies, structural activity relationship studies (SAR). The past ten years alterations unveiled by β-carboline analogs present in phytoconstituents and various derivatives of synthesized analogs with the mechanism of action were briefly shortlisted and illustrated.

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Indole Alkaloids from Marine Sources as Potential Leads against Infectious Diseases

Cited by 26 publications

References 80 publications

Isolation and Antibacterial Activity of Indole Alkaloids from Pseudomonas aeruginosa UWI-1

Isolation and Antibacterial Activity of Indole Alkaloids from Pseudomonas aeruginosa UWI-1

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives – An update

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