Indole Alkaloids from the Cigar Tobacco-Derived Endophytic Fungus Aspergillus oryzae and Their Antibacterial Activity

Li, Man-fei; Xiao, Dong; Zhu, Ling-Chao; Liu, Lu; Zheng, Jun-Na; Gu, Xue-Jiao; Zhu, Yanyan; Xie, Jiao; Wang, Xu; Dai, Jia-Meng; Mi, Qi-Li; Yang, Ye‐Kun; Hu, Qiu‐Fen; Li, Yin-Ke; Shi, Jian-Quan

doi:10.1007/s10600-022-03872-x

Cited by 6 publications

(1 citation statement)

References 26 publications

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“…Kojic acid and its derivatives also serve as a raw material for antibacterial, antifungal, and anti-inflammatory agents in the pharmaceutical industry [28][29][30]. Researchers have also discovered polysaccharides with anti-tumor activity [31,32], active compounds against Alzheimer's disease, antibacterial compounds [33,34], and enzyme inhibitors [35] from various A. oryzae strains. Although ergosterol, squalene, ceramide, and other common secondary metabolites are synthesized by A. oryzae, there is still limited knowledge on the potential of A. oryzae in producing other secondary metabolites, with reports that the known compounds represent only a minor fraction of the secondary metabolites produced by A. oryzae [3,[36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Strategies for the Enhancement of Secondary Metabolite Production via Biosynthesis Gene Cluster Regulation in Aspergillus oryzae

Jia,

Song,

et al. 2024

JoF

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The filamentous fungus Aspergillus oryzae (A. oryzae) has been extensively used for the biosynthesis of numerous secondary metabolites with significant applications in agriculture and food and medical industries, among others. However, the identification and functional prediction of metabolites through genome mining in A. oryzae are hindered by the complex regulatory mechanisms of secondary metabolite biosynthesis and the inactivity of most of the biosynthetic gene clusters involved. The global regulatory factors, pathway-specific regulatory factors, epigenetics, and environmental signals significantly impact the production of secondary metabolites, indicating that appropriate gene-level modulations are expected to promote the biosynthesis of secondary metabolites in A. oryzae. This review mainly focuses on illuminating the molecular regulatory mechanisms for the activation of potentially unexpressed pathways, possibly revealing the effects of transcriptional, epigenetic, and environmental signal regulation. By gaining a comprehensive understanding of the regulatory mechanisms of secondary metabolite biosynthesis, strategies can be developed to enhance the production and utilization of these metabolites, and potential functions can be fully exploited.

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