Indole Diterpenoids and Isocoumarin from the Fungus, Aspergillus flavus, Isolated from the Prawn, Penaeus vannamei

Sun, Kunlai; Li, Ye; Guo, Lei; Wang, Yi; Li, Peipei; Zhu, Weiming

doi:10.3390/md12073970

Cited by 65 publications

(65 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For geometric details of indole compounds, see: Krishna et al (1999). For circular dichroism experiments on the title compound, see: Sun et al (2014). For information on the Cambridge Structural Database (CSD), see: Groom & Allen (2014) Hydrogen-bond geometry (Å , ).…”

Section: Related Literaturementioning

confidence: 99%

Crystal and molecular structure of aflatrem

et al. 2015

View full text Add to dashboard Cite

The crystal structure of the title compound, C32H39NO4, confirms the absolute configuration of the seven chiral centres in the molecule. The molecule has a 1,1-dimethylprop-2-enyl substituent on the indole nucleus and this nucleus shares one edge with the five-membered ring which is, in turn, connected to a sequence of three edge-shared fused rings. The skeleton is completed by the 7,7-trimethyl-6,8-dioxabicyclo[3.2.1]oct-3-en-2-one group connected to the terminal cyclohexene ring. The two cyclohexane rings adopt chair and half-chair conformations, while in the dioxabicyclo[3.2.1]oct-3-en-2-one unit, the six-membered ring has a half-chair conformation. The indole system of the molecule exhibits a tilt of 2.02 (1)° between its two rings. In the crystal, O—H⋯O hydrogen bonds connect molecules into chains along [010]. Weak N—H⋯π interactions connect these chains, forming sheets parallel to (10-1).

show abstract

Section: Related Literaturementioning

confidence: 99%

Crystal and molecular structure of aflatrem

et al. 2015

View full text Add to dashboard Cite

show abstract

“…After incubation at 37 C for 12 h, the MIC value was defined as the lowest concentration of compound that produced an inhibition zone against the tested pathogens. [17] The experiment was performed in duplicate with full agreement between both results.…”

Section: Evaluation Of Antibacterial Activitymentioning

confidence: 98%

Bioassay-guided fractionation and identification of active substances from the fungusAspergillus tubingensisagainstVibrio anguillarum

Guo

Zhu

2016

Biotechnology & Biotechnological Equipment

Self Cite

View full text Add to dashboard Cite

The aim of this study was to perform bioassay-guided fractionation and identification of active substances against the aquatic pathogen Vibrio anguillarum from the fungus Aspergillus tubingensis SZX-6 associated with the crab Portunus trituberculatus. Based on the antibacterial activity against V. anguillarum, three compounds were isolated and purified from the culture broth of strain SZX-6 by sequential column chromatography over silica gel, Sephadex LH-20 and RP-18. The isolated compounds were identified on the basis of extensive spectroscopic data analysis. They were methyl 6-acetyl-5,7,8-trihydroxy-4-methoxy-2-naphthoate (1), daidzein (2) and genistein (3). Compound 1 showed moderate antibacterial activity against V. anguillarum (minimum inhibitory concentration 0.063 mg/mL). The obtained results could serve as a basis for further research towards design of active antibacterial agents against aquatic pathogens.

show abstract

“…In 2009, iso-α-cyclopiazonic acid (213), along with its isomer 210, was structurally characterized in the marine algae-derived A. flavus C-F-3 [169], the marine prawn-derived A. flavus OUCMDZ-2205 [170], and marine-derived P. camemberti [171]. Two new CPA derivatives, amycocyclopiazonic acid (214) and amycolactam (215), were isolated from a sponge-associated rare actinomycete Amycolatopsis sp.…”

Section: α-Cyclopiazonic Acid (Cpa)-type Tetramic Acidsmentioning

confidence: 99%

The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms

Jiang

Chen

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

Tetramic acid (pyrrolidine-2,4-dione) compounds, isolated from a variety of marine and terrestrial organisms, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities. In the past decade, marine-derived microorganisms have become great repositories of novel tetramic acids. Here, we discuss the biological activities of 277 tetramic acids of eight classifications (simple 3-acyl tetramic acids, 3-oligoenoyltetramic acids, 3-decalinoyltetramic acid, 3-spirotetramic acids, macrocyclic tetramic acids, N-acylated tetramic acids, α-cyclopiazonic acid-type tetramic acids, and other tetramic acids) from marine-derived microbes, including fungi, actinobacteria, bacteria, and cyanobacteria, as reported in 195 research studies up to 2019.

show abstract

Indole Diterpenoids and Isocoumarin from the Fungus, Aspergillus flavus, Isolated from the Prawn, Penaeus vannamei

Cited by 65 publications

References 38 publications

Crystal and molecular structure of aflatrem

Crystal and molecular structure of aflatrem

Bioassay-guided fractionation and identification of active substances from the fungusAspergillus tubingensisagainstVibrio anguillarum

The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms

Contact Info

Product

Resources

About