Indole synthesis through transition metal-catalyzed C–H activation

Gold‐Catalyzed Functionalization Reactions of Indole

“…[1][2][3][4] Therefore, since its discovery and characterization in 1866, [5] enormous efforts have been dedicated to the development of efficient methods for its preparation [6][7][8][9][10][11][12] and functionalization. Indole is probably one of the most important and intensively studied heterocyclic systems in different research areas, including pharmaceutical, agrochemical, and materials sciences.…”

Rhenium‐ and Manganese‐Catalyzed Selective Alkenylation of Indoles

“…With MnBr(CO) 5 as catalyst, we tested the influence of different solvents and THF proved to be the best reaction medium, providing the desired product 3a in 68 %y ield (Table 1, entries [11][12][13][14]. Evaluation of different additives revealed that additivesa re crucial for this transformation (Table 1, entries 15-20).…”

“…Indoles and derivatives have attracted great attention due to their important biological and pharmaceutical activities and synthetic applications. [10,11] Thus, numerousm ethods have been developedf or the regioselective synthesis of C2 and C3 functionalized indoles. [12] Compared to the well established indole C2-arylation,d irect regioselective C2-alkenylation is less explored.…”

Copper‐Catalyzed Indole Synthesis

“…The relative inexpensive copper and its variable oxidation states have elevated it to prominence for indole synthesis; numerous recent reviews are available [1][2][3][4][5][6][7][8].…”