Indolo[3,2- c ]cinnolines with antiproliferative, antifungal, and antibacterial activity

Azo group(s) in selected macrocyclic compounds

“…These compounds are used in manufacturing of dyes, electrochromic polymers, coloured polyamide fibers and have microbial and herbicidal activities [ 93 , 94 ]. Cinnolines were also studied as potential anticancer agents [ 95 , 96 ]. The reduction of 2,2′-dinitrobiphenyl to 3,4-benzocinnoline (benzo[ c ]cinnoline) 2 (Scheme 2 ) was first described by Wohlfart [ 97 ] and later by other groups [ 98 – 107 ].…”

Microwave assisted one-pot green synthesis of cinnoline derivatives inside natural sporopollenin microcapsules

“…Most of heterocycles exhibit biological activities and are therefore of great importance for organic synthesis. 25 Cinnoline derivatives are an important class of N-containing heteroaromatics and found intriguing interest as a privileged structures utilised as potential anticancer, 26,27 anti-inammatory, 28 antibacterial, 29 uorescent agents 30 cell imaging 31 and in designing liquid crystals. 32,33 We have used in the current study a novel polyfunctional cinnoline derivative based on the reaction of ethyl 5-cyano-4-methyl-1-aryl-6-oxo-1,6-dihydropyridazine-3carboxylate with nitroolens (Scheme 1) under controlled microwave irradiation that has been recently introduced by Sadek et al 34 These novel cinnoline derivatives are inevitably entail more exploration of their promising physico-chemical properties and potential applications.…”

A Concise Synthesis to Benzo[c ]cinnolines via 2,2’-Dinitro-1,1’-Biphenyls Attained from a Novel Tailored Suzuki Cross-Coupling

“…Cinnoline moieties are frequently found in biologically active molecules, whereof numerous with attractive pharmacological properties such as antibacterial, anticancer, antimicrobial, anti‐inflammatory, antifungal, antihypertensive, antiulcer, cytotoxic, and topoisomerase inhibitor, see Figure .…”