Indomethacin spray for radiation oral mucositis -A report of five cases-

Ebina, Kiyoka; Kizawa, Yoshiyuki; Homma, Masato; Wada, Takahito; Momo, Kenji; Hosono, Hiroyuki; Kohda, Yukinao

doi:10.2512/jspm.2.301

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…reported that IMS significantly reduced radiation‐induced OM pain scores (face scale) in five patients from 2.4 ± 0.4 to 1.0 ± 0.1 ( p < .01). 13 These results from a limited number of case studies indicate that IMS may be effective against both drug‐ and radiation‐induced OM.…”

Section: Discussionmentioning

confidence: 96%

“…Hence, for IMS to be effective, it should be administered at 15–20 min before a meal and upon the onset of oral pain. To the best of our knowledge, this study is the first prospective study to describe the efficacy of IMS, and it involved the highest number of cases relative to previously reported studies 12–14 …”

Section: Discussionmentioning

confidence: 97%

“…To the best of our knowledge, this study is the first prospective study to describe the efficacy of IMS, and it involved the highest number of cases relative to previously reported studies. 12 , 13 , 14…”

Section: Discussionmentioning

confidence: 99%

“…IMS (0.25% indomethacin) was prepared in our hospital as described in a previous report. 13 As indomethacin is almost insoluble in water, a stock solution was first prepared by dissolving 1.25 g of indomethacin (Fujifilm Wako Pure Chemical Corporation, Osaka, Japan) in 35 ml of 0.2‐M KH 2 PO 4 and 0.2‐M NaOH (pH = 8.8). Indomethacin sodium salt was then prepared by adding another 18 ml of 0.2‐M NaOH.…”

Section: Methodsmentioning

confidence: 99%

“…However, the analgesic effects of IMS have not been identified, and the in‐hospital preparation method of IMS is complex; therefore, it is rarely used in other facilities in Japan. There are few reports on the effects of oral IMS for treating OM pain, 12 , 13 , 14 and no prospective studies have described the efficacy of IMS in large number of cases. Therefore, this study aimed to evaluate the pain‐relieving effect of IMS, a nonmarketed in‐hospital preparation, on OM in patients receiving anticancer drug treatment.…”

Section: Introductionmentioning

confidence: 99%

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Analgesic effects of indomethacin spray on drug‐induced oral mucositis pain in patients with cancer: A single‐arm cross‐sectional study

Hata

Takada

Sato

et al. 2021

Special Care in Dentistry

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Aims Symptomatic treatment is insufficient for chemotherapy‐ or targeted therapy‐induced oral mucositis (OM) pain, and benzydamine mouthwash is not commercially available in Japan. We evaluated the analgesic effects of an in‐hospital preparation of 0.25% indomethacin spray (IMS) on anticancer drug‐induced OM pain. Methods This single‐arm prospective trial enrolled 20 patients (median age 62.0 years) with OM and numerical rating scale scores of ≥5 who were undergoing chemotherapy or targeted therapy in our hospital. Pain scores were recorded using a visual analog scale (VAS) before and 30 min after IMS administration. Pain relief (PR) scores were recorded at 15, 30, and 60 min after IMS administration; total PR after 60 min (TOTPAR60) was calculated, and the mean PR score after 3 days (PR3days) was determined. Results The median (interquartile range) OM grade of the participants was 2.0 (2.0–2.3). The VAS score decreased significantly at 30 min after IMS administration (p = .001). The median (interquartile range) TOTPAR60 and PR3days were 6.0 (3.8–7.3) and 2.0 (2.0–3.0), respectively. Conclusions IMS helped improve patients’ quality of life. The risk of systemic adverse effects was low because of the low dose administered. IMS effectively relieved anticancer drug‐induced OM pain and may be useful for immediate self‐medication.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Analgesic effects of indomethacin spray on drug‐induced oral mucositis pain in patients with cancer: A single‐arm cross‐sectional study

Hata

Takada

Sato

et al. 2021

Special Care in Dentistry

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Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy

Momo

Nagaoka

Kizawa

et al. 2017

Support Care Cancer

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Indomethacin Spray Preparation for the Control of Pain Associated with Stomatitis Caused by Chemotherapy and Radiotherapy in Cancer Patients

Momo

2015

YAKUGAKU ZASSHI

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Severe stomatitis caused by chemotherapy and radiotherapy is accompanied by severe pain and results in a poor quality of life. We used a spray preparation of indomethacin (IM; 0.25％ IM dissolved in phosphate buŠer, pH 7.4), a nonsteroidal anti-in‰ammatory drug (NSAID) to control the pain associated with stomatitis at the University of Tsukuba Hospital. This review speciˆcally aimed to collect information on the use of the IM spray preparation, from our previous studies, to facilitate its proper use in a hospital setting. On studying the stability of the IM spray preparation, we concluded that the preparation should be kept in the refrigerator for daily use, and that it can be stored for at least 2 months at 4°C, and for 24 months at -20°C. To evaluate the e‹cacy of the IM spray preparation, we retrospectively surveyed its analgesic eŠects. Using the 10-grade Visual Analogue Scale in 23 patients, we found that pain associated with stomatitis was reduced from 10 to 4.7 after application of the spray. In conclusion, our study results on the stability and e‹cacy of the IM spray preparation have led to the proper use of the spray in cancer patients with stomatitis caused by chemotherapy and radiotherapy.

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Indomethacin spray for radiation oral mucositis -A report of five cases-

Cited by 5 publications

References 11 publications

Analgesic effects of indomethacin spray on drug‐induced oral mucositis pain in patients with cancer: A single‐arm cross‐sectional study

Analgesic effects of indomethacin spray on drug‐induced oral mucositis pain in patients with cancer: A single‐arm cross‐sectional study

Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy

Indomethacin Spray Preparation for the Control of Pain Associated with Stomatitis Caused by Chemotherapy and Radiotherapy in Cancer Patients

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