Induction and activity-dependent reversal of persistent LTP and LTD in lateral perforant path synapses in vivo

Abraham, Wickliffe C.; Mason-Parker, Sara E.; Irvine, Gemma I.; Logan, Barbara; Gill, Amelia I.

doi:10.1016/j.nlm.2005.12.007

Cited by 35 publications

(22 citation statements)

References 33 publications

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“…Changing the location of a hidden platform may be analogous, requiring a refinement or reconfiguration of the previously formed spatial map. Similarly, calcineurin knockout mice show both diminished LTD and poor performance in the delayed-matching-to-sample task (Zeng et al, 2001), while environmental enrichment, the most studied form of cognitive enhancement, increases the propensity for LTP, LTD, and depotentiation/dedepression (Duffy et al, 2001;Abraham et al, 2006;Artola et al, 2006). Modulation of LTD threshold has also been associated with cognitive dysfunction; for example, chronic stress reduces the induction threshold for LTD and leads to cognitive impairments (Xu et al, 1997;Yang et al, 2005).…”

Section: The Role Of Nr2b-dependent Synaptic Plasticity In Hippocampumentioning

confidence: 99%

D-Serine Augments NMDA-NR2B Receptor-Dependent Hippocampal Long-Term Depression and Spatial Reversal Learning

Duffy

Labrie

Roder

2007

Neuropsychopharmacol

159

135

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The contributions of hippocampal long-term depression (LTD) to explicit learning and memory are poorly understood. Electrophysiological and behavioral studies examined the effects of modulating NMDA receptor-dependent LTD on spatial learning in the Morris water maze (MWM). The NMDA receptor co-agonist D-serine substantially enhanced NR2B-dependent LTD, but not long-term potentiation (LTP) or depotentiation, in hippocampal slices from adult wild type mice. Exogenous D-serine did not alter MWM acquisition, but substantially enhanced subsequent reversal learning of a novel target location and performance in a delayed-matchingto-place task. Conversely, an NR2B antagonist disrupted reversal learning and promoted perseveration. Endogenous synaptic D-serine likely saturates during LTP induction because exogenous D-serine rescued deficient LTP and MWM acquisition in Grin1 D481N mutant mice having a lower D-serine affinity. Thus, D-serine may enhance a form of hippocampal NR2B-dependent LTD that contributes to spatial reversal learning. By enhancing this form of synaptic plasticity, D-serine could improve cognitive flexibility in psychiatric disorders characterized by perseveration of aberrant ideation or behaviors.

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Section: The Role Of Nr2b-dependent Synaptic Plasticity In Hippocampumentioning

confidence: 99%

D-Serine Augments NMDA-NR2B Receptor-Dependent Hippocampal Long-Term Depression and Spatial Reversal Learning

Duffy

Labrie

Roder

2007

Neuropsychopharmacol

159

135

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“…The surgery protocols and the placement of the electrodes for electrophysiological analysis of perforant path and Schaffer collateral field excitatory postsynaptic potentials (fEPSPs) and population spikes were as previously described (Irvine and Abraham, 2005;Abraham et al, 2006;Irvine et al, 2006). Briefly, the animals were anesthetized with ketamine hydrochloride (75 mg kg 21 , s.c.) and medetomidine hydrochloride (0.5 mg kg 21 , s.c.).…”

Section: Electrode Implantationmentioning

confidence: 99%

Hippocampal synaptic transmission and LTP in vivo are intact following bilateral vestibular deafferentation in the rat

et al. 2009

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Numerous studies in animals and humans have shown that damage to the vestibular system in the inner ear results in spatial memory deficits, presumably because areas of the brain such as the hippocampus require vestibular input to accurately represent the spatial environment. Consistent with this hypothesis, studies in animals have demonstrated that complete bilateral vestibular deafferentation (BVD) causes a disruption of place cell firing as well as theta activity. The aim of this study was to investigate whether BVD in rats affects baseline field potentials (field excitatory postsynaptic potentials and population spikes) and long-term potentiation (LTP) in CA1 and the dentate gyrus (DG) of awake freely moving rats up to 43 days post-BVD and of anesthetized rats at 7 months post-BVD. Compared to sham controls, BVD had no significant effect on either baseline field potentials or LTP in either condition. These results suggest that although BVD interferes with the encoding, consolidation, and/or retrieval of spatial memories and the function of place cells, these changes are not related to detectable in vivo decrements in basal synaptic transmission or LTP, at least in the investigated pathways.

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“…In 1973, LTP was described by Bliss and Lomo (1973) first in the dentate gyrus of anaesthetised rabbits. A brief high-frequency stimulation of the perforant path can induce a long-lasting enhancement in synaptic efficacy, which can last in the intact animal several days or even weeks (Abraham, 2003;Abraham et al, 1995Abraham et al, , 2006Abraham and Williams, 2008;Bekenstein and Lothman, 1991;Lynch et al, 1990;Manahan-Vaughan et al, 2003). For investigation of different forms of synaptic plasticity in the CA1 region of the hippocampus in the intact animal usually a recording electrode is implanted in the ipsilateral stratum radiatum for recording the field-EPSP, while stimulation electrodes are implanted in the ipsilateral CA3 (e.g.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous recording of the field-EPSP as well as the population spike in the CA1 region in freely moving rats by using a fixed “double”-recording electrode

Scherf

Frey

2010

Journal of Neuroscience Methods

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Induction and activity-dependent reversal of persistent LTP and LTD in lateral perforant path synapses in vivo

Cited by 35 publications

References 33 publications

D-Serine Augments NMDA-NR2B Receptor-Dependent Hippocampal Long-Term Depression and Spatial Reversal Learning

D-Serine Augments NMDA-NR2B Receptor-Dependent Hippocampal Long-Term Depression and Spatial Reversal Learning

Hippocampal synaptic transmission and LTP in vivo are intact following bilateral vestibular deafferentation in the rat

Simultaneous recording of the field-EPSP as well as the population spike in the CA1 region in freely moving rats by using a fixed “double”-recording electrode

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