Induction and post-transcriptional suppression of hepatic cytochrome p450 1a1 by 3,3′,4,4′-tetrachlorobiphenyl

White, Renee D.; Shea, Damian; Solow, A R; Stegeman, John J.

doi:10.1016/s0006-2952(96)00902-1

Cited by 49 publications

(54 citation statements)

References 48 publications

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“…Similar results have been described in studies of cultured chick embryo hepatocytes and porcine aorta endothelial cells exposed to high doses of CB 77 (Lambrecht et al, 1988;Sinclair et al, 1989;Stegeman et al, 1995;. In scup, the CB 77-dependent decrease in CYP1A was shown to be posttranscriptional and hypothesized to result from oxidative modification of the protein (White et al, 1997a).…”

Section: Polychlorinated Biphenylssupporting

confidence: 79%

“…While CYP1A mRNA remains elevated in rainbow trout exposed to high doses of CB 77 or 126 and in scup exposed to high doses of CB 77, CYP1A activity and protein both decrease at high doses (Gooch et al, 1989;Newsted et al, 1995;White et al, 1997a). Similar results have been described in studies of cultured chick embryo hepatocytes and porcine aorta endothelial cells exposed to high doses of CB 77 (Lambrecht et al, 1988;Sinclair et al, 1989;Stegeman et al, 1995;.…”

Section: Polychlorinated Biphenylssupporting

confidence: 61%

“…A number of studies in a range of fish species have demonstrated that CB 77 (Franklin et al, 1980;Melancon and Lech, 1983;Gooch et al, 1989;Monosson and Stegeman, 1991;Tyle et al, 1991;Lindstrom-Seppa et al, 1994;Newsted et al, 1995;Otto and Moon, 1995;Huuskonen et al, 1996;Sleiderlink and Boon, 1996;White et al, 1997a), CB 126 (Engwall et al, 1994;Newsted et al, 1995;Huuskonen et al, 1996;Palace et al, 1996) and CB 169 (James and Little, 1981;Miranda et al, 1990;Newsted et al, 1995) induce CYP1A in fish. Several studies have found that no P450 induction occurs in fish following treatment with PB-type congeners (i.e.…”

Section: Polychlorinated Biphenylsmentioning

confidence: 99%

“…In the fish model, scup (Stenotomus chrysops), the TCB-dependent decrease in CYP1A was shown to be post-transcriptional, and studies in microsomes showed that TCB can inactivate as well as inhibit scup CYP1A (White et al, 1997a). TCB is a ligand for scup CYP1A but is metabolized slowly (Gooch et al, 1989;White et al, 1997b).…”

Section: Introductionmentioning

confidence: 99%

“…TCB is a ligand for scup CYP1A but is metabolized slowly (Gooch et al, 1989;White et al, 1997b). Therefore, it was speculated that inactivation may be due to uncoupling of CYP1A and formation of ROS (White et al, 1997a). A number of enzymes (CYP2B, Cu,Zn-superoxide dismutase (SOD), Fe-SOD, lactoperoxidase, myeloperoxidase, xanthine oxidase) that use or produce H202 and that contain· a metal ion undergo oxidative auto-inactivation (Loosemore et al, 1980;Matheson and Travis, 1985;Beyer and Fridovich, 1987;Jenzer et al, 1987;Karuzina and Archakov, 1994).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Involvement of Cytochrome P450 1A in the toxicity of aryl hydrocarbon receptor agonists : alteration arachidonic acid metabolism and production of reactive oxygen species

Schlezinger¹

1998

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Section: Polychlorinated Biphenylssupporting

confidence: 79%

Section: Polychlorinated Biphenylssupporting

confidence: 61%

Section: Polychlorinated Biphenylsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Involvement of Cytochrome P450 1A in the toxicity of aryl hydrocarbon receptor agonists : alteration arachidonic acid metabolism and production of reactive oxygen species

Schlezinger¹

1998

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Effects of 3,3′,4,4′,5,5′‐hexachlorobiphenyl on cytochrome P4501A and estrogen‐induced vitellogenesis in rainbow trout (Oncorhynchus mykiss)

Donohoe

Wang-Buhler

Buhler

et al. 1999

Enviro Toxic and Chemistry

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Abstract-Estrogen-regulated synthesis of vitellogenin (Vg), a yolk-protein precursor required for reproduction, was monitored to explore the potential antiestrogenic effects of the coplanar polychlorinated biphenyl (PCB), 3,3Ј,4,4Ј,5,4,, in juvenile rainbow trout (Oncorhynchus mykiss). The effects of 17␤-estradiol on 3,4,5-HCB induction of cytochrome P4501A (CYP1A) were also examined. Trout were injected with 3,4,5-HCB (0.25, 2.5, 25, 50, or 100 mg/kg) or a vehicle control, and after 10 weeks, they were sampled or injected with 17␤-estradiol (0.1 mg/kg). Markers of vitellogenesis, such as liver somatic index, hepatic estrogen-binding sites, and plasma Vg concentrations, in 17␤-estradiol-treated fish were not affected by 3,4,5-HCB. Maximal induction of CYP1A protein and mRNA occurred at doses above 2.5 mg/kg, and 17␤-estradiol reduced CYP1A protein content at a single dose (0.25 mg 3,4,5-HCB/kg). Ethoxyresorufin-O-deethylase (EROD) activity was induced by 3,4,5-HCB doses of between 0.25 and 2.5 mg/kg, but induction was reduced at higher doses, indicating that 3,4,5-HCB suppressed CYP1A catalytic activity. In 3,4,5-HCB/17␤-estradiol-treated fish, plasma estradiol was significantly reduced at 100 mg 3,4,5-HCB/kg, but the depression was not associated with CYP1A induction or with other antiestrogenic effects. Although CYP1A was induced, 3,4,5-HCB did not interfere with vitellogenesis, which suggests that the PCB congener is not a potent antiestrogen in rainbow trout.

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Hepatic P4501A activity, plasma sex steroids, and gonadal steroidogenesis in vitro in yellow perch exposed to 3, 3′, 4, 4′, 5‐pentachlorobiphenyl

Dabrowska¹,

Fisher²,

Ciereszko³

et al. 2000

Enviro Toxic and Chemistry

Self Cite

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Yellow perch were given a single intraperitoneal injection of polychlorinated biphenyl (PCB) 126 dissolved in cornoil at nominal concentrations of 0, 10, 100, and 500 μg/kg body weight. Following the injection, the fish were held for four weeks under photothermal conditions characteristic for Ohio, USA, and fed a commercial fish food. Thereafter, they were sacrificed to examine the PCB 126 concentrations in the liver and to assess the contaminant effects on hepatic P4501A activity, reproductive hormones in plasma, and steroidogenic potential of gonads. The administered doses resulted in liver concentrations of 0.8 (corn oil control), 12.1, 38.9, and 174.5 μg/kg wet tissue weight. Hepatic P4501A indices were differentially affected depending on both the PCB 126 dose and fish gender. In untreated fish, the P4501A protein and ethoxyresorufin‐O ‐deethylase activity were several times lower in females than in males. In treated males, the hepatic P4501A was inhibited by all three PCB 126 doses. In females, a significant P4501A induction occurred in those dosed with 10 μg/kg, while no changes were found in the two higher‐dosed female groups in comparison to controls. A significant negative correlation was observed between hepatic P4501A indices and gonad somatic indexes values and plasma estradiol concentrations. The PCB 126 administration produced alterations in concentrations of plasma sex hormones in females but not in males. The in vitro steroidogenic potential of the female and male gonads was not affected by the in vivo PCB 126 treatment.

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Induction and post-transcriptional suppression of hepatic cytochrome p450 1a1 by 3,3′,4,4′-tetrachlorobiphenyl

Cited by 49 publications

References 48 publications

Involvement of Cytochrome P450 1A in the toxicity of aryl hydrocarbon receptor agonists : alteration arachidonic acid metabolism and production of reactive oxygen species

Involvement of Cytochrome P450 1A in the toxicity of aryl hydrocarbon receptor agonists : alteration arachidonic acid metabolism and production of reactive oxygen species

Effects of 3,3′,4,4′,5,5′‐hexachlorobiphenyl on cytochrome P4501A and estrogen‐induced vitellogenesis in rainbow trout (Oncorhynchus mykiss)

Hepatic P4501A activity, plasma sex steroids, and gonadal steroidogenesis in vitro in yellow perch exposed to 3, 3′, 4, 4′, 5‐pentachlorobiphenyl

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