Induction and recovery characteristics of isoflurane and halothane anaesthesia for short outpatient operations in children

Pandit, Uma A.; Steude, Georgine M.; Leach, Andrew

doi:10.1111/j.1365-2044.1985.tb10665.x

Cited by 40 publications

(22 citation statements)

References 6 publications

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“…The vocalization and marked expiratory efforts which occurred in a minority of rabbits occurred after loss of consciousness, and were probably caused by laryngospasm. This has been reported in children following face-mask induction with isoflurane (Pandit et al 1985), 73 and may also contribute to an increased risk of anaesthetic mortality during induction with volatile anaesthetics in rabbits.…”

Section: Discussionmentioning

confidence: 96%

Induction of anaesthesia with halothane and isoflurane in the rabbit: a comparison of the use of a face-mask or an anaesthetic chamber

Flecknell

Cruz

Liles³

et al. 1996

Lab Anim

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SummaryThe effects of induction of anaesthesia with halothane or isoflurane were studied in rabbits. The anaesthetic agents were delivered either via a face-mask, or the animals were placed in an anaesthetic induction chamber. All rabbits had periods of apnoea during induction, lasting 30-120 s, resulting in moderate hypercapnia and acidosis. Periods of apnoea were associated with a marked bradycardia. The combination of bradycardia and hypercapnia during induction may represent an increased risk of anaesthetic associated mortality. Animals in all groups tried to avoid inhaling anaesthetic vapour, and this behaviour, together with the occurrence of breathholding suggests that induction was aversive.

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Section: Discussionmentioning

confidence: 96%

Induction of anaesthesia with halothane and isoflurane in the rabbit: a comparison of the use of a face-mask or an anaesthetic chamber

Flecknell

Cruz

Liles³

et al. 1996

Lab Anim

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“…also reported that isoflurane could be used as an alternative to halothane for rapid inhalation anaesthesia induction [4]. Although isoflurane does not have the potential for hepatic toxicity associated with halothane, it does cause considerably more complications during conventional inhalational induction [6]. Loper rt ul.…”

Section: Discussionmentioning

confidence: 99%

Vital capacity breath technique for rapid anaesthetic induction: comparison of sevoflurane and isoflurane

Yurino

Kimura

1992

Anaesthesia

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SummaryThis study compares vital capacity rapid inhalational induction of anaesthesia with sevofurane and isoflurane. Forty-six volunteers undergoing the procedure had one of the two agents: 2.5 had sevoflurane and 21 isc?purune. Subjects were unpremedicated and breathed approximately 1.7 MAC equivalents of either vapour. There were no signifcant diflerences in the patients' monitored cardiovascular, respiratory, and electrocardiographic variables. The mean time for induction of anaesthesia with sevojurane (I20 s) was significantly shorter than with isojurane (145 s), reflecting its higher blood-gas solubility. There were,fewer induction complications in the sevofurane group. Subjects in the sevopurane group found the induction of anaesthesia more pleasant and were more willing to undergo it again compared to subjects in the isoflurane group. We conclude that sevoflurane is superior to isofiurane in vital capacity rapid inhalational induction of anaesthesia, particularly in instances uvhere premedication should be avoided. Key wordsAnaesthetics volatile; isoflurane, sevoflurane. E.witator,v phase; induction.Ruffle and colleagues described the technique of vital capacity rapid inhalational induction (VCRII) in 200 patients [I], who were instructed to take a vital capacity breath of 4% halothane in oxygen, and to hold it in the lungs for 30-90s until loss of consciousness. The VCRII technique had certain advantages over conventional inhalation and intravenous induction of anaesthesia, including prompt induction without a prolonged excitatory phase and full recovery without 'hangover'. An editorial in Lancet acknowledged these advantages, but emphasised the potential for hepatic toxicity in repeated halothane anaesthesia [2].Two studies have described isoflurane as an alternative to halothane for VCRII [3,4]. They showed that isoflurane induced loss of consciousness more rapidly than halothane because of its lower blood-gas solubility and that isoflurane was well tolerated by patients. Sevoflurane, on the other hand, has an even lower blood-gas solubility than isoflurane [5], and could be expected to induce anaesthesia more rapidly. In this study, we compared sevoflurane and isoflurane for VCRII. MethodsThe study was approved by the Clinical Human Research Committee, and informed consent was obtained from each volunteer. Forty-six healthy volunteers were randomly divided into two groups. Twenty-five were assigned to the sevoflurane (S) group and 21 to the isoflurane (I) group, but they were unaware to which group they had been assigned. The groups were demographically similar with no significant differences between them in respect of age, sex, weight, or height. The S group breathed 3% sevoflurane in oxygen, and the I group 2% isoflurane in oxygen. These concentrations represented approximately I .7 MAC equivalents of each agent. None were premedicated.Mixtures of each anaesthetic agent together with oxygen were delivered by an Ohmeda Vapor vaporizer into the circle system of an Ohmeda anaesthesia machine. The insp...

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“…Theoretically, these favorable qualities are accentuated in those volatile anesthetics with lower blood/gas solubility such as isoflurane, sevoflurane, and desflurane making the idea of their use in horses additionally attractive. However, a high incidence of irrational, disoriented behavior has been observed in children emerging from isoflurane and desflurane compared to halothane and sevoflurane 4,5 …”

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confidence: 99%

The Recovery of Horses From Inhalant Anesthesia: A Comparison of Halothane and Isoflurane

et al. 2000

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Induction and recovery characteristics of isoflurane and halothane anaesthesia for short outpatient operations in children

Abstract: Summary

Cited by 40 publications

References 6 publications

Induction of anaesthesia with halothane and isoflurane in the rabbit: a comparison of the use of a face-mask or an anaesthetic chamber

Induction of anaesthesia with halothane and isoflurane in the rabbit: a comparison of the use of a face-mask or an anaesthetic chamber

Vital capacity breath technique for rapid anaesthetic induction: comparison of sevoflurane and isoflurane

The Recovery of Horses From Inhalant Anesthesia: A Comparison of Halothane and Isoflurane

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