INDUCTION BY ANTIBIOTICS AND COMPARATIVE SENSITIVITY OF L-PHASE VARIANTS OF
            <i>STAPHYLOCOCCUS AUREUS</i>

Molander, C. W.; Kagan, Benjamin M.; Weinberger, Howard J.; Heimlich, E. M.; Busser, R.

doi:10.1128/jb.88.3.591-594.1964

Cited by 20 publications

(3 citation statements)

References 13 publications

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“…It is an antibiotic that shows antibacterial effects mainly against Staphylococcus spp. [57,71]. The inhibitory antiviral activity was described in Epstein-Barr virus [58] and others DNA viruses by acting in the viral replication step [59].…”

Section: Novobiocinmentioning

confidence: 99%

Challenger Treats Zika Virus

Carvalho

Watanabe

Kallás

2018

Curr Treat Options Infect Dis

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Purpose of review Arthropod-borne viruses (arboviruses) are zoonotic, and the common vectors are ticks and hematophagous mosquitoes. Currently, dengue, chikungunya, yellow fever, West Nile, and Japanese encephalitis virus infections have been causing worldwide concerns. In 2015, a large outbreak was documented with another mosquito-borne flavivirus, the Zika virus (ZIKV), and ravaging South and Central Americas and the Caribbean. ZIKV was declaring a public health emergency, because of the clinical evidence neurological complications. Recent findings The flavivirus infection is difficult to differentiate only with clinical manifestation. It has been reported 2366 cases of microcephaly or congenital defects associated with ZIKV in Brazil, and the mechanism or processes that lead to these neurological complications are still under investigation. No antivirals are available to treat ZIKV infection, leading to no option to prevent the fetal infection during pregnancy which could avoid the congenital Zika syndrome. In this review, we will describe the drugs that are being tested in vitro and in animal models against ZIKV. Summary We reviewed several publications that test the compounds for the treatment of ZIKV disease. We conclude that some of these compounds testing in vitro and in vivo have shown a therapeutic possibilities to consider and to be test in pregnancy and in individuals with high risk of infection.

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Section: Novobiocinmentioning

confidence: 99%

Challenger Treats Zika Virus

Carvalho

Watanabe

Kallás

2018

Curr Treat Options Infect Dis

View full text Add to dashboard Cite

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“…Antibiotics such as β -lactams target cell wall synthesis, making the dividing cells most vulnerable. Bacteria are known to evade the effect of β -lactam exposure by losing the cell walls [6], halting their division temporarily [7] and then resuming their normal growth at the end of the treatment [8]. The bacteria respond to antimicrobials by controlling cell division, thus, going into survival mode [9].…”

Section: Introductionmentioning

confidence: 99%

A novel approach for combining the metagenome, metaresistome, metareplicome and causal inference to determine the microbes and their antibiotic resistance gene repertoire that contribute to dysbiosis

et al. 2022

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The use of whole metagenomic data to infer the relative abundance of all its microbes is well established. The same data can be used to determine the replication rate of all eubacterial taxa with circular chromosomes. Despite their availability, the replication rate profiles (metareplicome) have not been fully exploited in microbiome analyses. Another relatively new approach is the application of causal inferencing to analyse microbiome data that goes beyond correlational studies. A novel scalable pipeline called MeRRCI (Metagenome, metaResistome, and metaReplicome for Causal Inferencing) was developed. MeRRCI combines efficient computation of the metagenome (bacterial relative abundance), metaresistome (antimicrobial gene abundance) and metareplicome (replication rates), and integrates environmental variables (metadata) for causality analysis using Bayesian networks. MeRRCI was applied to an infant gut microbiome data set to investigate the microbial community’s response to antibiotics. Our analysis suggests that the current treatment stratagem contributes to preterm infant gut dysbiosis, allowing a proliferation of pathobionts. The study highlights the specific antibacterial resistance genes that may contribute to exponential cell division in the presence of antibiotics for various pathogens, namely Klebsiella pneumoniae, Citrobacter freundii, Staphylococcus epidermidis, Veilonella parvula and Clostridium perfringens . These organisms often contribute to the harmful long-term sequelae seen in these young infants.

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“…Although bacitracin has an antibiotic action similar to that of penicillin, the production of L forms with this antibiotic has not been documented. Two attempts to produce L forms from bacteria with bacitracin have met with failure (Ward, Madoff, and Dienes, 1958;Molander et a]., 1964). This report is concerned with the isolation of L forms from group A streptococci exposed to bacitracin.…”

mentioning

confidence: 99%

Isolation of L Forms from Group A Streptococci Exposed to Bacitracin

1965

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Isolation of L forms from group A streptococci exposed to bacitracin. J. Bacteriol. 89:1581-1585. 1965.-L forms were obtained from group A streptococci by exposure to bacitracin on gradient plates, although novobiocin was ineffective in this respect. Subcultures of these L forms had morphological and bacteriological properties similar to those obtained with penicillin. M protein was detected in L-form colony smears by immunofluorescent staining with type-specific conjugate. The L forms were not stained with group-specific conjugate. Parallel precipitin tests performed with extracts from a heavy growth of L forms on agar confirmed these findings. Thus, the L forms obtained with bacitracin continue to produce M protein but are devoid of the group-specific carbohydrate which is a major component of cell-wall structure.

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INDUCTION BY ANTIBIOTICS AND COMPARATIVE SENSITIVITY OF L-PHASE VARIANTS OF STAPHYLOCOCCUS AUREUS

Cited by 20 publications

References 13 publications

Challenger Treats Zika Virus

Challenger Treats Zika Virus

A novel approach for combining the metagenome, metaresistome, metareplicome and causal inference to determine the microbes and their antibiotic resistance gene repertoire that contribute to dysbiosis

Isolation of L Forms from Group A Streptococci Exposed to Bacitracin

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