Induction by bombesin of peritoneal metastasis of gastric cancers induced by N -methyl- N ?-nitro- N -nitrosoguanidine in Wistar rats

Tatsuta, Masaharu; Baba, Miyako; Narahara, Hiroyuki; Uedo, Noriya; Yano, Hiroyuki; Yamamoto, Reiko; Mukai, Mutsuko; Akedo, Hitoshi

doi:10.1007/s101200100011

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“…BLPs mediate tumor cell invasion and metastasis by stimulating the expression and activation of several integrins, PP125FAK tyrosine phosphorylation, and MMP-9 (4,5,19,28,33). Bombesin significantly increased the incidence of peritoneal metastasis from gastric cancers and intestinal adenocarcinomas (30,31). Very recently, Qiao et al have demonstrated that GRPR silencing suppressed the metastatic potential of neuroblastoma (26).…”

Section: Discussionmentioning

confidence: 99%

Specific Antibodies Elicited by a Novel DNA Vaccine Targeting Gastrin-Releasing Peptide Inhibit Murine Melanoma Growth In Vivo

Fang

Ouyang

et al. 2009

Clin Vaccine Immunol

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The elevated expression and receptor binding of gastrin-releasing peptide (GRP) in various types of cancer, especially in malignant melanoma of the skin, suggest that GRP might be a putative target for immunotherapy in neoplastic diseases. We have therefore constructed a novel DNA vaccine coding for six tandem repeats of a fragment of GRP from amino acids 18 to 27 (GRP6) flanked by helper T-cell epitopes for increased immunogenicity, including HSP65, a tetanus toxoid fragment from amino acids 830 to 844 (T), pan-HLA-DR-binding epitope (

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