Induction chemotherapy for squamous cell carcinomas of the oral cavity: a cumulative meta-analysis

Abstract

Background: In current head and neck oncology practice, threedimensional (3D) computed tomography (CT) based virtual planning of resection and reconstruction, followed by guided surgery, is standard of care. However, tumours are usually well visible on magnetic resonance imaging (MRI) while less clearly on CT. Objectives: The aim of this study was to improve the current workflow by developing a method for obtaining 3D MRI-based mandible models, in order to plan the bony resection margins with MRI-based visualisation of the tumour. Methods: A workflow for MRI based surgical planning and guided surgery was developed using a four-step approach, including a general exploration phase, test series, validation series and guided surgery. Key MRI parameters were defined in phase 1, followed by application of selected sequences on healthy volunteers in phase 2. The optimised MRI protocol was validated by application on a patient series (n = 10) and comparison to CT data of the same patient, phase 3. Phase 4 provided examination of the clinical value during surgery. Findings: Three black bone sequences were applied for all cases. In comparison-analysis, mean deviation values between the MRIand the CT-based models were found to be 0.56 mm, 0.50 mm and 0.58 mm. Guided surgery was performed in two cases resulting in a mean deviation of the resection planes of 2.3 mm, 3.8 mm for the fibula segments, and a mean axis deviation of the fibula segments of 1.9 •. Conclusion: This study provides a method for 3D virtual resection planning and guided surgery, based on solely MRI imaging. Therefore no additional CT data fusion is required.

Actein Antagonizes Oral Squamous Cell Carcinoma Proliferation through Activating FoxO1

“…Over the past few decades, multiple OSCC management strategies have been evaluated in clinical contexts; such strategies have included surgical interventions, radiation treatment, and chemotherapeutic therapies with platinum drugs. Meanwhile, because of variations in anatomical subsites and underlying molecular pathological features and pathological stages, OSCC management approaches have always incorporated multiple treatment modalities [3]. However, survival rates among late-stage OSCC patients remain low.…”