Induction of anaemia in monkeys

Wolcott, George J.; Valentine, J. A.; Cebul, Randall D.

doi:10.1258/002367773780943996

Cited by 3 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Narasinga Rao et al [12] demonstrated the usefulness of the monkey as an animal model for iron absorption studies. Apart from phylo genetic closeness to humans, the ferrokinetics of monkeys are also similar to those of hu mans [13,14], Therefore, the monkey was chosen as an animal model to test the validity of serum ferritin and also to understand the sequential changes in iron status parameters with the development of mild iron defi ciency.…”

mentioning

confidence: 99%

Induction of Dietary Iron Deficiency in Rhesus Monkeys: Sequential Changes in Serum Ferritin and Other Biochemical Indicators of Iron Status

et al. 1994

View full text Add to dashboard Cite

The usefulness of serum ferritin as a measure of subclinical stages of iron deficiency has been tested in monkeys by inducing a mild iron deficiency dietarily over a period of 12 months. Various biochemical indicators of iron status were measured periodically along with analysis of liver iron and iron staining of bone marrow samples obtained by biopsy, at the end of the experiment. A mild form of iron deficiency was confirmed by bone marrow staining for iron. Of all the biochemical indicators tested, significant decreases were seen in hemoglobin and hematocrit at the 11th and 10th months, respectively. These changes were consistent with the changes later found in bone marrow grading for iron. Serum ferritin concentration and liver iron concentration did not show any significant difference between the controls and iron-deficient monkeys. Thus, these results do not support the existence of a latent stage of iron deficiency. In the mild form of iron deficiency, the functional compartment, represented by bone marrow iron and hemoglobin, is sensitive to depletion even when there were no changes in storage compartment represented by liver iron and serum ferritin.

show abstract

mentioning

confidence: 99%

Induction of Dietary Iron Deficiency in Rhesus Monkeys: Sequential Changes in Serum Ferritin and Other Biochemical Indicators of Iron Status

et al. 1994

View full text Add to dashboard Cite

show abstract

“…The exper imental design, the mode of iron depletion-repletion and the initial hematological and bone marrow grading of the animals are given in table l. The control animals were subdivided into 2 groups (groups l and 2) and received an iron-depleted diet. In addition, phleboto my was carried out in group 2 animals by removing about 10% of their estimated blood volume per week for 7 weeks [6], The iron-deficient monkeys were sub divided into 4 groups (groups 3-6) and were repleted for a period of 3 months. Groups l -4 received an irondeficient diet which contained only 20-30 mg of iron/ kg.…”

Section: Materials and M Ethodsmentioning

confidence: 99%

Changes in Biochemical Indicators of Iron Status during Iron Repletion and Depletion in Monkeys

Sreeramulu¹,

Nair²,

Qadri³

et al. 1997

Ann Nutr Metab

View full text Add to dashboard Cite

Different modes of iron depletion and repletion were studied in monkeys to understand the sequential changes in and the relative importance of different biochemical indicators of iron status. Six control monkeys were divided into two groups, one was fed an iron-deficient diet (group 1) and the other underwent phlebotomy in addition to receiving an iron-deficient diet (group 2). Previously iron-depleted monkeys were subdivided into 4 groups of 3 animals each. While one group was continued on the iron-deficient diet (group 3), the second group received parenteral iron (group 4), the third group (group 5) received a sufficient-iron-containing diet, and the fourth group was fed 50% of the iron requirement. All indicators of iron status like hemoglobin (Hb), erythrocyte protoporphyrin (EPP), serum transferrin saturation and serum ferritin were monitored periodically, in addition to liver and bone marrow iron. All the indicators except serum ferritin and liver iron showed a decrease in group 2. On the other hand, animals receiving parenteral iron (group 4) showed an increase in all the parameters except serum ferritin. The dietary supplementation produced an increase in Hb and a decrease in EPP only (groups 5 and 6). There was a significant positive correlation between changes in bone marrow iron and Hb concentration depending on the severity of depletion and repletion. Both serum ferritin and liver iron did not respond to changes in dietary iron. Another parameter which responded to repletion was EPP. Serum ferritin and liver iron did not respond to changes in dietary iron or was not sensitive to subclinical iron deficiency. The results indicate that change in Hb is more sensitive to detect the deficiency of iron. It was also observed that different parameters respond variably under different modes of depletion and repletion.

show abstract

Chapter^>26: ABO Blood Group System

2015

Erythrocytes of the Rhesus and Cynomolgus Monkeys

View full text Add to dashboard Cite

Induction of anaemia in monkeys

Cited by 3 publications

References 1 publication

Induction of Dietary Iron Deficiency in Rhesus Monkeys: Sequential Changes in Serum Ferritin and Other Biochemical Indicators of Iron Status

Induction of Dietary Iron Deficiency in Rhesus Monkeys: Sequential Changes in Serum Ferritin and Other Biochemical Indicators of Iron Status

Changes in Biochemical Indicators of Iron Status during Iron Repletion and Depletion in Monkeys

Chapter^>26: ABO Blood Group System

Contact Info

Product

Resources

About