SUMMARY
Three children with Down's syndrome are reported with spontaneously occurring myoclonic seizures. Electroencephalograms were markedly abnormal, but improved after medication in two cases. Seizures were controlled with drugs in two of the children, but are not well controlled in the third, despite attempts with several types of medication. The aetiology of these myoclonic seizures remains unclear.
RÉSUMÉ
Crises myocloniques dans le mongolisme
Les auteurs rapportent les cas de trois jeunes mongoliens ayant présenté spontanément des crises myocloniques. Les eegétaient très anormaux mais améliorés après traitement dans deux cas. Les crises ont été contrôlées par médication chez deux enfants, beaucoup moins bien chez le troisième en dépit de l'essai de plusieurs types de médicaments. L'étiologie de ces crises myocloniques demeure peu claire.
ZUSAMMENFASSUNG
Myoklonische Anfälle bei Down Syndrom
Es wird über drei Kinder mit Down Syndrom berichtet, die spontan auftretende myoklonische Anfälle hatten. Die eegs waren hochgradig abnorm, besserten sich jedoch in zwei Fällen unter der Medikation. Die Anfälle wurden bei zwei der Kinder durch Medikamente unter Kontrolle gebracht, nicht beim dritten trotz Anwendung mehrerer Medikamente. Die Ätiologie dieser myoklonischen Krämpfe bleibt unklar.
RESUMEN
Crisis mioclónicas en el síndrome de Down
Se citan tres niños con el sindrome de Down, con episodios espontáneos de mioclonias. Los eeg eran marcadamente anormales pero mejoraron en dos casos después de la medicación. Las crisis fueron controladas con fármacos en dos de los niños, pero no están bien controladas en el tercero a pesar de ensayar diversos tipos de medicación. La etiología de estas crisis mioclónicas no queda clara.
20 healthy young adult male rhesus monkeys were bled 3 times a week in an attempt to induce an anaemia and a depletion of iron stores. A mean haemoglobin of 6·1 g/IOO ml and a haematocrit of 23 % were obtained by 30 days. The iron saturation had fallen to a level of 11% and the reticulocyte response to 4·6 %. Of note was the short period required to induce these haematological changes, and the minimal impact on the animals.
Although medication is often prescribed to enhance the learning potential of children, procedures for obtaining feedback from teachers on drug effectiveness have been largely ignored. The value of teachers' informal feedback to physicians has been limited due to its subjectivity. The procedures described represent one of a number of potential methods by which the teacher and physician can work as a team to provide the best drug dosage for each child. - G.M.S.
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