Induction of apoptosis in lung carcinoma cells by antiproliferative cyclic lipopeptides from marine algicolous isolate Bacillus atrophaeus strain AKLSR1

Routhu, Sunitha Rani; Chary, R. Nagarjuna; Shaik, Anver Basha; Prabhakar, S.; Kumar, C. Ganesh; Kamal, Ähmed

doi:10.1016/j.procbio.2018.12.010

Cited by 25 publications

(20 citation statements)

References 58 publications

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“…Therefore, the selective targeting of cancer cells with cyclic peptides is related to the differences between cancerous and normal cells (Henriques et al., 2014; Mehta et al., 2020). Moreover, it was suggested that CLPs from B. atrophaeus inhibited the growth of cancer cells by inducing reactive oxygen species (ROS) accumulation and nuclear fragmentation leading to cell apoptosis (Routhu et al., 2019).…”

Section: Function and Bioactive Mechanism Of Mdcpsmentioning

confidence: 99%

“…CLPs have a linkage between hydrocarbon tails and the N‐terminus, which are chemically modified or possess unusual amino acid residues (Zhao et al., 2019). Their structures depend on the factors that would influence the growth of producers, such as metabolic activity and physical and nutritional parameters (Biniarz & Aukaszewicz, 2017; Routhu et al., 2019). Due to the amphipathic property of lipopeptides, as well as various other bioactivities like antibacterial, antifungal, and antitumor activities, their applications in biological process control and therapy have already been generally studied.…”

Section: Classification and Structural Characteristics Of Mdcpsmentioning

confidence: 99%

“…Due to the amphipathic property of lipopeptides, as well as various other bioactivities like antibacterial, antifungal, and antitumor activities, their applications in biological process control and therapy have already been generally studied. Their biocompatibility and biodegradability as biosurfactants also provided significance for the biomedical and food industries (Routhu et al., 2019). Bacillus spp.…”

Section: Classification and Structural Characteristics Of Mdcpsmentioning

confidence: 99%

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A comprehensive review of microorganism‐derived cyclic peptides: Bioactive functions and food safety applications

Luo

Liu

et al. 2022

Comp Rev Food Sci Food Safe

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Cyclic peptides possess advanced structural characteristics of stability and play a vital role in medical treatment and agriculture. However, the biological functions of microorganism-derived cyclic peptides (MDCPs) and their applications in food industry were relatively absent. MDCPs are derived from extensive fermented food or soil. In this review, the synthesis approaches and structural characteristics are overviewed, while the interrelationship between bioactivities and functions is emphasized. This review summarizes the bioactivities of MDCPs from in vitro to in vivo, including antimicrobial activities, immune regulation, and antiviral cell activation. Their multiple functions as well as applications during food product processing, packaging, and storage are also comprehensively reviewed. Remarkably, some potential risks and cytotoxicity of MDCPs are also critically discussed. Moreover, future applications of MDCPs in the development of novel food additives and bioengineering materials are organized. Based on this review of native MDCPs, it is noteworthy that expected improvements of synthetic cyclic peptides in bioactive properties present potential valuable applications in future food, including artificial meat.

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Section: Function and Bioactive Mechanism Of Mdcpsmentioning

confidence: 99%

Section: Classification and Structural Characteristics Of Mdcpsmentioning

confidence: 99%

Section: Classification and Structural Characteristics Of Mdcpsmentioning

confidence: 99%

See 1 more Smart Citation

A comprehensive review of microorganism‐derived cyclic peptides: Bioactive functions and food safety applications

Luo

Liu

et al. 2022

Comp Rev Food Sci Food Safe

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“…The Dictyota dichotoma (Phaeophyceae) from marine macroalgae [110], the compound akiyoshiensis GRG 6 (KY457710) from marine Streptomyces [111] along with coibamide A (CA) from marine cyanobacterium [112] were able to cause apoptosis in breast cancer cells. The chromomycin SA analogs isolated from marine-derived Streptomyces [113], the cyclic lipoheptapeptides isolated from marine algicolous bacterial [114] and three chromone derivatives isolated from marine-derived Penicillium citrinum [115] were shown to work against lung cancers. The extracts derived from marine sponges [116], alkaloid aaptamine from marine sponges [117] and some extracts from marine fungus [118] decreased the proliferation of liver cancer cells.…”

Section: Potential Marine-derived Anticancer Drugsmentioning

confidence: 99%

Development of Marine-Derived Compounds for Cancer Therapy

Zuo

Kwok

2021

Marine Drugs

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Cancer has always been a threat to human health with its high morbidity and mortality rates. Traditional therapy, including surgery, chemotherapy and radiotherapy, plays a key role in cancer treatment. However, it is not able to prevent tumor recurrence, drug resistance and treatment side effects, which makes it a very attractive challenge to search for new effective and specific anticancer drugs. Nature is a valuable source of multiple pharmaceuticals, and most of the anticancer drugs are natural products or derived from them. Marine-derived compounds, such as nucleotides, proteins, peptides and amides, have also shed light on cancer therapy, and they are receiving a fast-growing interest due to their bioactive properties. Their mechanisms contain anti-angiogenic, anti-proliferative and anti-metastasis activities; cell cycle arrest; and induction of apoptosis. This review provides an overview on the development of marine-derived compounds with anticancer properties, both their applications and mechanisms, and discovered technologies.

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“…Além da atividade antimicrobiana, a surfactina também é estudada por possuir atividade antitumoral. Routhu et al,62 isolaram uma linhagem de Bacillus atrophaeus da alga marinha Padina tetrastromatica. A citotoxicidade da mistura de surfactinas produzida foi estudada contra diferentes linhagens de células cancerígenas, como neuroblastoma, adenocarcinoma do pulmão, HeLa e uma linhagem de fibroblasto pulmonar não tumoral, usada como controle.…”

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Biossurfactante produzido por linhagem termo-halofílica de >i<Bacillus alveayuensis>/i<: caracterização química e avaliação da atividade tensoativa em meio poroso com óleo e sobre microrganismos

Argentin¹

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foi usado em testes de atividade antifúngica contra onze linhagens de fungos fitopatogênicos, onde foi observada completa inibição do crescimento das hifas em Moniliophthora perniciosa, Phytophthora sojae e Lasidiplodia euphorbicola e inibição parcial em Ceratocystis paradoxa, Sclerotinia sclerotiorum, Rhizopus microsporus, Aspergillus flavus e Aspergillus niger. A atividade do tensoativo também foi testada contra as linhagens bacterianas Bacillus subtilis (ATTC 6633 e 21332), Staphylococcus epidermidis (ATTC 12228 e 35984), Pseudomonas fluorescens (ATTC 13525), Escherichia coli (ATTC 25922) e Desulfovibrio marinus BRS-1. Nos testes de microdiluição o biossurfactante causou uma inibição inicial pronunciada no crescimento de B. subtilis 6633, S. epidermidis (12228 e 35984), e moderada em P. fluorescens 13525. Sobre a bactéria redutora de sulfato D. marinus BRS-1 o biossurfactante mostrou ação bacteriostática e bactericida nas concentrações 2.250e 2.500 µg/mL, respectivamente. O tensoativo semipurificado teve sua capacidade de recuperação de óleo em meio poroso avaliada pelo método de lavagem de areia, sendo capaz de remover, aproximadamente, 30% do óleo de motor (10W40) presente na amostra. O bissurfactante produzido pela linhagem estudada mostrou potencial aplicação em processos de MEOR e biorremediação de óleo, além de ser capaz de inibir o crescimento de fungos e bactérias, podendo ter utilidade com agente de biocontrole.

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Induction of apoptosis in lung carcinoma cells by antiproliferative cyclic lipopeptides from marine algicolous isolate Bacillus atrophaeus strain AKLSR1

Cited by 25 publications

References 58 publications

A comprehensive review of microorganism‐derived cyclic peptides: Bioactive functions and food safety applications

A comprehensive review of microorganism‐derived cyclic peptides: Bioactive functions and food safety applications

Development of Marine-Derived Compounds for Cancer Therapy

Biossurfactante produzido por linhagem termo-halofílica de >i<Bacillus alveayuensis>/i<: caracterização química e avaliação da atividade tensoativa em meio poroso com óleo e sobre microrganismos

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