Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcification

Hsu, Howard H.T.; Camacho, Nancy P.; Tawfik, Ossama; Sun, Francis

doi:10.1016/s0021-9150(01)00623-2

Cited by 32 publications

(30 citation statements)

References 24 publications

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“…Cholesterol seems to be the initial trigger for the nidus of calcification to form. In atherosclerotic rabbits, the development of atheromatous plaque is a prerequisite for calcification (37,38). In bench-top studies, addition of cholesterol to the calcium phosphate crystals formed shapes similar to those seen in human plaques (39).…”

Section: Accelerated Atherosclerotic Calcification In Chronic Kidney mentioning

confidence: 91%

Accelerated Atherosclerotic Calcification and Mo[Combining Diaeresis]nckeberg's Sclerosis

McCullough

Agrawal

Danielewicz

et al. 2008

Clinical Journal of the American Society of Nephrology

174

103

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Autopsy studies have demonstrated the near universal presence of fatty streaks and fibroatheromas in the general population from which patients with chronic kidney disease (CKD) arise. The vast majority of patients with CKD have multiple conventional cardiovascular risk factors. Vascular atherosclerotic calcification develops in most patients as they transition from the general population to significant CKD as part of cholesterol crystallization within atherosclerotic lesions. Once present, however, atherosclerotic medial calcification can become prominent and has been previously identified as Mö nckeberg's sclerosis. A unifying concept supported by the preponderance of pathologic evidence contends that Mö nckeberg's sclerosis is a manifestation of accelerated atherosclerosis in patients with CKD. The term has also been used in rare cases to describe vascular calcinosis not related to CKD. This clarification is critical to advance the field in terms of pathologic diagnosis and treatment of CKD bone and mineral disorder. Factors that seem to promote the osteoblastic transformation of vascular smooth muscle cells and enhance deposition of calcium hydroxyapatite crystals include phosphorus activation of the Pit-1 receptor, bone morphogenic proteins 2 and 4, leptin, endogenous 1,25 dihydroxyvitamin D, vascular calcification activating factor, and measures of oxidative stress. These entities work to accelerate the atherosclerotic process in patients with CKD and may be future targets for diagnosis and treatment because randomized trials with hydroxymethylglutaryl-CoA reductase inhibitors have failed to attenuate the rate of progressive vascular calcification.

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Section: Accelerated Atherosclerotic Calcification In Chronic Kidney mentioning

confidence: 91%

Accelerated Atherosclerotic Calcification and Mo[Combining Diaeresis]nckeberg's Sclerosis

McCullough

Agrawal

Danielewicz

et al. 2008

Clinical Journal of the American Society of Nephrology

174

103

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“…For this reason, FTIR spectroscopy was applied to obtain both chemical and spatial information on the distribution of different components within atherosclerotic arteries. Whereas one study [78] examined atherosclerotic human artery under moist conditions, other studies detected the calcification in thin dried sections of rabbit aortas both in transmission mode [79][80][81] and micro-ATR reflection mode [82].…”

Section: Atherosclerosismentioning

confidence: 99%

Disease recognition by infrared and Raman spectroscopy

Krafft¹,

Steiner²,

Beleites³

et al. 2009

Journal of Biophotonics

265

175

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Infrared (IR) and Raman spectroscopy are emerging biophotonic tools to recognize various diseases. The current review gives an overview of the experimental techniques, data-classification algorithms and applications to assess soft tissues, hard tissues and body fluids. The methodology section presents the principles to combine vibrational spectroscopy with microscopy, lateral information and fiber-optic probes. A crucial step is the classification of spectral data by a variety of algorithms. We discuss unsupervised algorithms such as cluster analysis or principal component analysis and supervised algorithms such as linear discriminant analysis, soft independent modeling of class analogies, artificial neural networks support vector machines, Bayesian classification, partial least-squares regression and ensemble methods. The selected topics include tumors of epithelial tissue, brain tumors, prion diseases, bone diseases, atherosclerosis, kidney stones and gallstones, skin tumors, diabetes and osteoarthritis.

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“…As características da enfermidade observada no presente trabalho são diferentes das presentes na calcificação da artéria aorta induzida por dietas ricas em colesterol, em que ocorre uma mineralização distrófica, e na arterioesclerose espontânea de origem genética dos coelhos, que aparece desde a sexta semana de idade e acomete a parede da artéria aorta e artérias coronárias, sendo rara em outros vasos (GAMAN et al, 1967;ROKITA et al, 1991;ESPER et al, 1993;HSU et al, 2002).…”

Section: Discussionunclassified

Prevalência e aspectos anatomopatológicos da mineralização metastática em coelhos provenientes de biotérios e criação comercial do Estado do Rio de Janeiro, Brasil

et al. 2008

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Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcification

Cited by 32 publications

References 24 publications

Accelerated Atherosclerotic Calcification and Mo[Combining Diaeresis]nckeberg's Sclerosis

Accelerated Atherosclerotic Calcification and Mo[Combining Diaeresis]nckeberg's Sclerosis

Disease recognition by infrared and Raman spectroscopy

Prevalência e aspectos anatomopatológicos da mineralização metastática em coelhos provenientes de biotérios e criação comercial do Estado do Rio de Janeiro, Brasil

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