Induction of Cell Proliferation and Collagen Synthesis in Human Small Intestinal Lamina Propria Fibroblasts by Lipopolysaccharide: Possible Involvement of Nitric Oxide

Chakravortty, Dipshikha; Kumar, K.S.Nanda

doi:10.1006/bbrc.1997.7680

Cited by 44 publications

(28 citation statements)

References 28 publications

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“…Whereas there is much evidence describing how epithelial cells depend on fibroblast soluble secreting factors to proliferate (28,29), little is known about the activating components required to induce the proliferation and secretion of cytokines by fibroblasts. Chakravortty and Kumar (30) noted that induction of cell proliferation and collagen synthesis in intestinal subepithelial myofibroblasts was mediated by LPS, whereas Maas-Szabowski et al (31) have reported that interleukin-1 promoted the growth of human dermal fibroblasts. Therefore, TLR activation permits the clearance of infection through cytokine induction and promotes cell growth in scenarios of tissue repair.…”

Section: Myd88-induced Degradation Of P27 Is Blocked By Dominant Negamentioning

confidence: 99%

Toll-like Receptor Signaling Stimulates Cell Cycle Entry and Progression in Fibroblasts

Hasan¹,

Trinchieri²,

Vlach³

2005

Journal of Biological Chemistry

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Section: Myd88-induced Degradation Of P27 Is Blocked By Dominant Negamentioning

confidence: 99%

Toll-like Receptor Signaling Stimulates Cell Cycle Entry and Progression in Fibroblasts

Hasan¹,

Trinchieri²,

Vlach³

2005

Journal of Biological Chemistry

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“…Because LPS has been shown to affect cell growth in certain cell types 32 and toxicity has been reported with certain NO donors, both microendothelial cells and macrophages were counted after each experiment with the aid of a hemocytometer and cell viability assessed by trypan blue exclusion.…”

Section: Isolation and Culture Of Microvascular Endothelial Cells Andmentioning

confidence: 99%

Regulatory Effects of iNOS on Acute Lung Inflammatory Responses in Mice

Speyer

Neff

Warner

et al. 2003

The American Journal of Pathology

167

117

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The role of endogenous NO in the regulation of acute lung injury is not well defined. We investigated the effects of inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) on the acute inflammatoryThere is abundant evidence that lung inflammatory injury, occurring after a variety of insults, is due to activation of lung phagocytic cells, which produce numerous chemokines (reviewed).1 CXC chemokines are thought to attract neutrophils into the lung, while CC chemokines attract lymphocytes and monocytes and also have the ability to activate macrophages.2 It is well known that a variety of lung cells other than phagocytic cells have the ability to generate cytokines and chemokines.3 For inflammatory reactions that lead to injury, the role of NO is controversial, with evidence for pro-inflammatory as well as antiinflammatory effects. 4 In various lung injury models, neutrophil recruitment, cytokine production, and oxygen radical production were reduced in the presence of either inhaled NO or exogenous NO donors, suggesting a beneficial role for NO in acute lung injury. [5][6][7] In contrast, a decrease in lung permeability and neutrophil recruitment was shown in various models of lung injury using NO synthase (NOS) inhibitors, suggesting a harmful effect of NO on lung injury. 8 -10

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“…propria of the small intestine (Chakravortty, Kumar, 1997) and in the re-epithelialization of normal skin as part of the healing processes (Stallmeyer et al, 1999;Hsu et al, 2006). Witte and coworkers (2000) revealed that although the NO donor used in the study presented a cytostatic effect on fibroblasts, the administration of low concentrations of NO donor in rat dermal fibroblast cultures enhanced collagen synthesis.…”

Section: Discussionmentioning

confidence: 98%

The in vivo effect of L-arginine on skin elasticity in mice

Souza

Oliveira

Andrade

et al. 2017

Braz. J. Pharm. Sci.

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The human skin aging process is a complex mechanism that can be induced both by intrinsic and extrinsic factors. Observations include a decrease in the biosynthetic and proliferative capacity of cells, increased expression of matrix metalloproteinases, reduction in collagen type I expression, and the progressive disappearance of elastic tissue in the papillary dermis. L-arginine, the substrate of nitric oxide synthesis, is involved in angiogenesis and cell proliferation, as well as an indirect precursor of collagen synthesis via the proline pathway. The aim of this study was to examine the tensile strength, histology, and immunohistochemistry of female and male mice skin receiving different concentrations of topically applied L-arginine, in order to evaluate the possibility of using L-arginine as an active cosmetic ingredient in antiaging products. The results suggest that the application of L-arginine improves the mechanical resistance of skin from older female mice (20 weeks old) and promotes the formation of a larger amount of collagen and elastic fibers in the skin when applied at a concentration of 15%.

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Induction of Cell Proliferation and Collagen Synthesis in Human Small Intestinal Lamina Propria Fibroblasts by Lipopolysaccharide: Possible Involvement of Nitric Oxide

Cited by 44 publications

References 28 publications

Toll-like Receptor Signaling Stimulates Cell Cycle Entry and Progression in Fibroblasts

Toll-like Receptor Signaling Stimulates Cell Cycle Entry and Progression in Fibroblasts

Regulatory Effects of iNOS on Acute Lung Inflammatory Responses in Mice

The in vivo effect of L-arginine on skin elasticity in mice

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