Induction of cyclic flow reduction in the coronary, carotid, and femoral arteries of conscious, chronically instrumented dogs

Al-Wathiqui, Mahmood H.; Hartman, J. Craig; Brooks, Harold L.; Warltier, David C.

doi:10.1016/0160-5402(88)90018-6

Cited by 10 publications

(1 citation statement)

References 12 publications

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“…Subsequently, similar phenomena have been reported in various species, including coronary artery in pigs (1), carotid artery in monkeys (7,35), carotid and femoral arteries in dogs (3), femoral and carotid arteries in rabbits (10,12), and popliteal artery in humans (9). The underlying cause of unstable angina (3,34) and transient ischemic attacks (3,25) have been attributed to CFRs in the coronary and carotid arteries, respectively. However, as far as we are aware, CFRs have not been previously described in intracranial arteries.…”

Section: Discussionmentioning

confidence: 99%

Increased cerebral infarction by cyclic flow reductions: studies in the guinea pig MCA thrombosis model

Kawano

Ikeda

Kondo

et al. 1998

American Journal of Physiology-Regulatory, Integrative and Comp

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We have developed a photochemical model of thrombotic middle cerebral artery (MCA) occlusion in the guinea pig for investigating factors contributing to the development of cerebral infarction. In this model, cyclic flow reductions (CFRs) after recanalization of the MCA are a common observation and might contribute to the development of cerebral infarction. Therefore, we sought to measure the time course of recanalization of the guinea pig MCA after the artery had been occluded by a thrombus. Thrombotic occlusion of the MCA was induced by photochemical reaction between intravenously administered rose bengal and transluminal green light for 10, 15, 20, or 30 min. After the thrombotic occlusion of MCA and subsequent spontaneous thrombolysis, blood flow in the MCA gradually recovered to preocclusion level but with frequent CFRs. The recovery of MCA blood flow or duration of CFRs was dependent on the duration of photochemical reaction (extent of endothelial injury); thus, for a 30-min photochemical reaction, CFRs were still observed 24 h after photochemical reaction. In separate experiments, we also investigated the effect of permanent occlusion of the MCA, which was induced by electrocoagulation in the vessel on cerebral infarction. The infarct volume in the permanent occlusion model was smaller than the maximum value in the thrombotic occlusion model (12.5 vs. 17.4%; P < 0.05, n = 6). CFRs may constitute an important factor contributing to the extent of cerebral infarction.

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