Induction of cytochrome P450 as a biomarker for environmental contamination in aquatic ecosystems

Short-term responses of Oryzias latipes (Pisces: Adrianichthyidae) and Macrobrachium nipponense (Crustacea: Palaemonidae) to municipal and pharmaceutical waste water in Beijing, China: survival, behaviour, biochemical biomarkers

“…EROD and AHH, showed reduced toxicity in the effluent, compared to the inflow. The MFO enzymes EROD and AHH are good indicators for organochlorine pesticides, PAHs and PCBs as well as paper mill effluents, being more sensitive than other biochemical, cellular and organ level biomarkers (Bucheli and Fent, 1995;Holdway et al, 1995). However, GC analysis of the water showed no elevated concentrations for organic compounds.…”

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“…(Hong et al, 2007), increased E2 in males could be a result of an increase in aro matase activity. In past, numerous studies indicated that exposure to OP pesticides induces or enhances the activity of P 450 enzy mes (Munkittrick et al, 1994;Bucheli & Fent, 1995, Husoy, Myers, & Goksoyr, 1996Dong et al, 2013).…”

Use of Biochemical Markers for the Assessment of Organic Pollutant Contamination of the Vltava river, Czech Republic

“…Only the total content of CYP 450 was assessed in this study, not specifically the 1A isoform. The response of total CYP 450 content is less sensitive than that in the case of the selected isoenzymes (Bucheli and Font 1995). It was demonstrated that single xenobiotic compounds can act as inducers of specific isoenzymes, but can inhibit others.…”